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Epidemiologie und Diagnostik der Retrovirusinfektion

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Zusammenfassung

Zu den transfusionsmedizinisch relevanten Retroviren gehören das humane Immundefizienz-Virus (HIV-1, HIV-2) und das HTLV-I (human T-lymphotropic virus) [1]. Beide, das HIV-1 und HIV-2, sind Auslöser des erworbenen Immundefekt-Syndroms (Acquired Immune Deficiency Syndrome = AIDS). Das HTLV-I ist der mutmaßliche Auslöser der T-Zell-Leukämie des Erwachsenen (ATLL), der tropisch spastischen Paraparese (TSPP) und der HTLV-I-assoziierten Myelopathie (HAM) (Tabelle 1 und Tabelle 2).

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Literatur

  1. Gallo RC (1988) HIV-infection: A review of human retroviruses, pathogenic effect, and prospects for a vaccine. In: Allain JP, Gallo RC, Montagnier L (eds) Human Retroviruses and Diseases they cause. Elsevier, Amsterdam

    Google Scholar 

  2. Schüpbach J (1986) Retroviren, menschliche Tumoren und Autoimmunerkrankungen. Schweiz Med Wschr 116:1126–1133

    PubMed  Google Scholar 

  3. Norley SG, Kurth R (1989) Retrovirus and malignant lymphoma. Blut 58:221–227

    Article  PubMed  CAS  Google Scholar 

  4. Baltimore D (1970) RNA-dependent DNA polymerase in virions of RNA tumor viruses. Nature 226:1209–1211

    Article  PubMed  CAS  Google Scholar 

  5. Panza CD (1988) HIV persistence in monocytes leads to pathogenesis and AIDS. Cellul Immunol 112:414–424

    Article  Google Scholar 

  6. Gallo RC (1984) Human T-cell leukaemia-lymphoma virus and T-cell malignancies in adults. Cancer Surveys 3:113–159

    Google Scholar 

  7. Barre-Sinoussi F, Chermann JC, Rey F et al. (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS). Science 220:868–871

    Article  PubMed  CAS  Google Scholar 

  8. Gallo RC, Salahuddin SZ, Popovic M et al. (1984) Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and risk for AIDS. Science 224:500–503

    Article  PubMed  CAS  Google Scholar 

  9. Kühnl P, Sibrowski W, Seidl S et al. (1989) Aktueller Stand der HIV-Epidemiologie und Diagnostik. In: Maurer C (Hrsg) Entwicklungen in der Transfusionsmedizin. Ecomed, Landsberg-München-Zürich, S 11–27

    Google Scholar 

  10. Allen JR (1987) Transmission of human immunodeficiency virus (HIV) by blood and blood components. In: Moore SB (ed) American Association of Blood Banks (AABB). Arlington, Va, USA

    Google Scholar 

  11. AIDS-Nachrichten 5:1–10 (1990)

    Google Scholar 

  12. Clavel F, Guetard D, Brun-Vezinet F et al. (1986) Isolation of a new human retrovirus from West African patients with AIDS. Science 233:343–346

    Article  PubMed  CAS  Google Scholar 

  13. Barin F, Denis F, Allan JS et al. (1985) Serological evidence for virus related to simian T-lymphotropic retrovirus III in residents of West Africa. Lancet ii:1387–1389

    Article  Google Scholar 

  14. Brun-Vezinet F, Katlama C, Roulot D et al. (1987) Lymphadenopathy-associated virus type 2 in AIDS and AIDS-related complex: Clinical and virological features in four patients. Lancet i:128–132

    Article  Google Scholar 

  15. Clavel F, Mansinho K, Chamaret S et al. (1987) Human immunodeficiency virus type 2 infection associated with AIDS in West Africa. New Engl J Med 316:1180–1185

    Article  PubMed  CAS  Google Scholar 

  16. Kanki P (1987) West African human retroviruses related to STLV-III (editorial review). AIDS 3:141–145

    Google Scholar 

  17. Kong LI, Lee SW, Kappes JC et al. (1988) West African HIV-2-related human retrovirus with attenuated cytopathicity. Science 240:1525–1529

    Article  PubMed  CAS  Google Scholar 

  18. Evans LA, Moreau J, Odehouri K et al. (1988) Characterization of a noncytopathic HIV-2 strain with unusual effects on CD4 expression. Science 240:1522–1525

    Article  PubMed  CAS  Google Scholar 

  19. Minamoto G, Jonathan WM, Gold WM et al. (1988) Infection with human T-cell leukemia virus type I in patients with leukemia. New Engl J Med 318:219–222

    Article  PubMed  CAS  Google Scholar 

  20. Okochi K, Sato H, Hinuma YA (1984) A retrospective study on transmission of adult T-cell leukemia virus by blood transfusion: seroconversion in recipients. Vox Sang 46:245–253

    Article  PubMed  CAS  Google Scholar 

  21. Sandler SG, Fang C (1987) HTLV-I and other retroviruses. In: Moore SB (ed) Transfusion-transmitted viral diseases, American Association of Blood Banks (AABB). Arlington, Va, USA, pp 19–35

    Google Scholar 

  22. Petz LD, Saxton E, Lee H et al. (1989) A case of transfusion-transmitted HTLV-I-associated myelopathy. Transfusion [Suppl] 29:55

    Google Scholar 

  23. Gout O, Banlac M, Gessain A et al. (1990) Rapid development of myelopathy after HTLV-I infection acquired by transfusion during cardiac transplantation. New Engl J Med 322:383–388

    Article  PubMed  CAS  Google Scholar 

  24. Schwarzfischer G, Schätzl H, Bäcker U, Weise K, V. d. Helm K, Deinhardt F (1990) HTLV-I-Antikörperscreening bei Blutspendern, Abstr Bd. DGTI-Symposium, Kassel, S 10

    Google Scholar 

  25. Robert-Guroff M, Weiss SH, Giron JA et al. (1985) Prevalence of antibodies to HTLV-I,-II and-III in intravenous drug abusers from an AIDS endemic region. JAMA 255:3133–3137

    Article  Google Scholar 

  26. Glück D, Vornwald A, Gossrau E et al. (1990) HIV-prevalence in blood donors in urban and in rural areas of the Federal Republic of Germany. Blut 60:304–307

    Article  PubMed  Google Scholar 

  27. Frösner GG (1988) Veränderung der Inzidenz der AIDS-Erkrankung und geschätzte Prävalenz der HIV-Infektion in der Bundesrepublik Deutschland. AIFO 5:269–276

    Google Scholar 

  28. Estermann J, Koch MA (1990) Prävalenzen und Inzidenzen von HIV. Dt Ärztebl 87:1755–1757

    Google Scholar 

  29. Frösner GG (1988) Welche Aussagekraft haben die Ergebnisse der AIDS-Laborbe-richtspflicht? Dt Ärztebl 85:2092–2094

    Google Scholar 

  30. Menitove JE (1989) The decreasing risk of transfusion-associated AIDS. New Engl J Med 321:966–968

    Article  PubMed  CAS  Google Scholar 

  31. Ness PM, Douglas D, Koziol D et al. (1990) Decreasing seroprevalence of human immuno-deficiency virus type 1 in regional blood donor populations. Transfusion 30:201–206

    Article  PubMed  CAS  Google Scholar 

  32. Kühnl P (1986) HTLV-III/LAV-Antikörpertests: Ringversuche der Deutschen Blutspendedienste. AIFO 10:525–535

    Google Scholar 

  33. Reesink HW, Lelie PN, Huisman JG et al. (1986) Evaluation of six enzyme immunoassays for antibody against human immunodeficiency virus. Lancet ii:483–486

    Article  Google Scholar 

  34. Rübsamen-Waigmann H (1990) Woher kommt das AIDS-Virus? 3. Dt AIDS-Kongreß, Abstr Nr. 1

    Google Scholar 

  35. Monos DS, Frank TS, Senior MB et al. (1989) Delineation of false-positive HIV antibody response in patients with renal failure and history of multiple transfusion. Transfusion 29:119–123

    Article  PubMed  CAS  Google Scholar 

  36. Arnow PM, Fellner S, Harrington R et al. (1988) False-positive results of screening for antibodies to human immunodeficiency virus in chronic hemodialysis patients. Amer J Kidney Dis 11:383–386

    CAS  Google Scholar 

  37. Burke DS, Brundage JF, Redfield RR et al. (1988) Measurement of false positive rate in a screening program for human immunodeficiency virus infections. New Engl J Med 319:961–964

    Article  PubMed  CAS  Google Scholar 

  38. Jackson JB, MacDonald KL, Cadwell J et al. (1990) Absence of HIV infection in blood donors with indeterminate Western blot tests for antibody to HIV-1. New Engl J Med 322:217–222

    Article  PubMed  CAS  Google Scholar 

  39. Knüver-Hopf J, Mohr H, Beyer J et al. (1989) HIV-2 antibody testing of blood donors with doubtful immunoblot results for HIV-1. Blut 58:155–157

    Article  PubMed  Google Scholar 

  40. Nusbacher J, Naiman R (1989) Longitudinal follow-up of blood donors found to be reactive for antibody to human immunodeficiency virus by enzyme-linked immunoassay but negative by Western blot. Transfusion 29:365–367

    Article  PubMed  CAS  Google Scholar 

  41. Maass G (1990) Probleme bei der Auswertung des Western-Blot für die HIV-Diagnostik. 3. Dt AIDS-Kongreß, Abstr. Vol. Hamburg

    Google Scholar 

  42. Schmitz H (1990) Die Bedeutung der Polymerase-Kettenreaktion für den Nachweis des HIV. 3. Dt AIDS-Kongreß, Abstr. Vol. Hamburg

    Google Scholar 

  43. Genesca J, Shih JWK, Jett BW et al. (1989) What do western blot indeterminate patterns for human immunodeficiency virus mean in EIA-negative blood donors. Lancet ii:1023–1025

    Article  Google Scholar 

  44. Haseltine WA (1989) Silent HIV Infections. New Engl J Med 320:1487–1488

    Article  PubMed  CAS  Google Scholar 

  45. Gaines H, Sonnerberg A, Czajkowski J et al. (1987) Antibody response in primary human immunodeficiency virus infection. Lancet ii:1249–1253

    Article  Google Scholar 

  46. Imagawa DT, Lee MH, Wolinsky SM et al. (1989) Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. New Engl J Med 320:1458–1462

    Article  PubMed  CAS  Google Scholar 

  47. Li-Zhen P, Royce R, Winkelstein W et al. (1989) (Letter). New Engl J Med 321:1680

    Google Scholar 

  48. Groopman J, Caiazzo T., Thomas MA et al. (1988) Lack of evidence of prolonged human immunodeficiency virus infection before antibody seroconversion. Blood 71:1752–1754

    PubMed  CAS  Google Scholar 

  49. Ranki A, Krohn M, Allain JP et al. (1987) Long latency precedes overt seroconversion in sexually transmitted human-immunodeficiency-virus infection. Lancet ii:589–593

    Article  Google Scholar 

  50. Wolinsky SM, Rinaldo CR, Kwok S et al. (1989) Human immunodeficiency virus type 1 (HIV-I) infection a median of 18 month before a diagnostic western blot: Evidence from a cohort of homosexual men. Ann Intern Med 111:961–972

    PubMed  CAS  Google Scholar 

  51. Farzadegan H, Polis MA, Wolinsky SM et al. (1988) Loss of human immunodeficiency virus type 1 antibodies with evidence of viral infection in asymptomatic homosexual men. Ann Int Med 108:785–790

    PubMed  CAS  Google Scholar 

  52. Cumming PD, Wallace EL, Schorr JB et al. (1989) Exposure of patients to human immunodeficiency virus through the transfusion of blood components that test antibody-negative. New Engl J Med 321:941–946

    Article  PubMed  CAS  Google Scholar 

  53. Kühnl P, Holzberger G, Seidl S (1987) Nachuntersuchung von Spendern und Empfängern HIV-Antikörper-positiver Blutkonserven. Dtsch Med Wschr 112:4–7

    Article  PubMed  Google Scholar 

  54. Ward JW, Hohnberg SD, Allen JR et al. (1988) Transmission of human immunodeficiency virus (HIV) by blood transfusion screened as negative for HIV antibody. New Engl J Med 318:473–478

    Article  PubMed  CAS  Google Scholar 

  55. Kleinman S, Secord K (1989) Risk of human immunodeficiency virus transmission by anti-HIV negative blood. Transfusion 28:499–501

    Article  Google Scholar 

  56. Cohen ND, Munoz A, Reitz BA et al. (1989) Transmission of retroviruses by transfusion of screened blood in patients undergoing cardiac surgery. New Engl J Med 320:1172–1176

    Article  PubMed  CAS  Google Scholar 

  57. Stute R (1987) HIV antigen detection in routine blood donor screening. Lancet i:566

    Article  Google Scholar 

  58. Busch MP, Taylor PE, Lenes BA et al. (1990) Screening of selected male blood donors for p24 antigen of human immunodeficiency virus type 1. New Engl J Med 323:1308–1312

    Article  PubMed  CAS  Google Scholar 

  59. Alter HJ, Epstein JS, Swenson SG et al. (1990) Prevalence of human immunodeficiency virus type 1 p24 antigen in US blood donors — an assessment of the efficacy of testing in donor screening. New Engl J Med 323:1312–1317

    Article  PubMed  CAS  Google Scholar 

  60. Zaia JA, Rossi JJ (1989) Confirmation of HIV infection using gene amplification. Transf Med Rev 3:27–30

    Article  CAS  Google Scholar 

  61. Jackson JB (1990) The polymerase chain reaction in transfusion medicine. Transfusion 30:51–57

    Article  PubMed  CAS  Google Scholar 

  62. Plasma-Consensus Conference (1985) Fresh-frozen plasma, indications and risks. JAMA 253:551–553

    Article  Google Scholar 

  63. Deicher H (1989) Aktuelle Aspekte der Transfusionsmedizin. Dt Ärztebl 86:836

    Google Scholar 

  64. Widmann FK (1990) Informed consent for blood transfusion. Transfusion 30:460–470

    Article  PubMed  CAS  Google Scholar 

  65. Clerk SJ, Saag MS, Decker DW et al. (1991) High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1-infection. New Engl J Med 324:954–960

    Article  Google Scholar 

  66. Greene WC (1991) The molecular biology of human immunodeficiency virus type I infection. New Engl J Med 324:308–317

    Article  PubMed  CAS  Google Scholar 

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© 1992 Springer-Verlag Berlin Heidelberg

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Sibrowski, W., Bassy, M., Kühnl, P. (1992). Epidemiologie und Diagnostik der Retrovirusinfektion. In: Hellstern, P., Maurer, C. (eds) Neue Entwicklungen in der Transfusionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77443-0_14

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  • DOI: https://doi.org/10.1007/978-3-642-77443-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55362-5

  • Online ISBN: 978-3-642-77443-0

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