The Molecular Pathology of Pancreatic Cancer
Our increased understanding of the molecular biology of oncogenes has allowed us to investigate the molecular events associated with pancreatic tumorigenesis. We are beginning to identify those oncogenic events that are necessary and sufficient to produce neoplasia and to determine their temporal sequence of activation. We can now reconstruct many of these events in vitro using gene transfer techniques to introduce activated cellular oncogenes into normal pancreatic epithelium in culture. These are exciting developments because we have the technology to detect oncogene activation for a molecular diagnosis of pancreatic cancer, and we have identified new targets for the design of therapeutic strategies.
KeywordsPancreatic Cancer Chronic Pancreatitis Pancreatic Adenocarcinoma Human Pancreatic Cancer Cellular Oncogene
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