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PSP, PTP, or REG Protein? The Role of Pancreatic Stone Protein

  • Conference paper
Standards in Pancreatic Surgery

Abstract

The occurrence of pancreatic calcifications in chronic pancreatitis (CP) has long been recognized [1–3] and accepted as a diagnostic criterion [3]. Among different pancreatic secretory proteins identified in the last decade, like pancreatic stone protein (PSP [4]), protein X [5], human pancreatic thread protein (PTP [6]), it has been argued that PSP plays a crucial role in the development of pancreatic calcifications, i.e., pancreatic stone formation.

This work was supported in part by grants No. 01 GA 8805, DFVLR-Bundes ministerium für Forschung und Technologie, and DFG-Schm/603-2, Deutsche Forschungsgemeinschaft

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References

  1. Friedreich N (1878) In: van Ziemssen H (ed) Cyclopaedia of the practice of medicine. Wood, New York, pp 600–603

    Google Scholar 

  2. Klob J (1860) Zur pathologischen Anatomie des Pankreas. Oesterr Z Prakt Heilkde (Wien) 6:629–634

    Google Scholar 

  3. Ring EJ, Eaton SB, Ferrucci JT, Short WF (1973) Differential diagnosis of pancreatic calcification. Am J Roentgenol 117:446–452

    CAS  Google Scholar 

  4. De Caro A, Lohse J, Sarles H (1979) Characterization of a protein isolated from pancreatic calculi of men suffering from chronic calcifying pancreatitis. Biochem Biophys Res Commun 87:1176–1182

    Article  PubMed  Google Scholar 

  5. Guy-Crotte O, Amouric M, Figarella C (1984) Characterisation and N-terminal sequence of a degradation product of 14000 molecular weight isolated from human pancreatic juice. Biochem Biophys Res Commun 125:516–523

    Article  PubMed  CAS  Google Scholar 

  6. Gross J, Carlson RI, Brauer AW, Margolies MN, Warshaw AL, Wands JR (1985) Isolation, characterization, and distribution of an unusual pancreatic human secretory protein. J Clin Invest 76:2115–2126

    Article  PubMed  CAS  Google Scholar 

  7. Lechene de la Porte P, De Caro A, Amouric M, Sarles H (1981) Localisation imunocytochimique de la protéine majoritaire de calculs pancréatiques humaines. Nouv Presse Med 10:3851

    Google Scholar 

  8. De Caro A, Multigner L, Lafont H, Lombardo D, Sarles H (1984) The molecular characteristics of a human pancreatic acidic phosphoprotein that inhibits calcium carbonate crystal growth. Biochem J 222:669–677

    PubMed  Google Scholar 

  9. Giorgi D, Bernard JP, De Caro A, Multigner L, Lapointe R, Sarles H, Dagorn JC (1985) Pancreatic stone protein: I. Evidence that it is encoded by a pancreatic messenger ribonucleic acid. Gastroenterology 89:381–386

    PubMed  CAS  Google Scholar 

  10. Figarella C, Amouric M, Guy-Grotte O (1984) Proteolysis of human trypsinogen 1. Pathogenic implication in chronic pancreatitis. Biochem Biophys Res Commun 118:154–161

    Article  PubMed  CAS  Google Scholar 

  11. Multigner L, De Caro A, Lombardo D, Campese O, Sarles H (1983) Pancreatic stone protein, a phosphoprotein which inhibits calcium carbonate precipitation from human pancreatic juice. Biochem Biophys Res Commun 110:69–74

    Article  PubMed  CAS  Google Scholar 

  12. Multigner L, Sarles H, Lombardo D, De Caro A (1985) Pancreatic stone protein: II. Implication in stone formation during the course of chronic calcifying pancreatitis. Gastroenterology 89:387–391

    PubMed  CAS  Google Scholar 

  13. Sarles H (1986) Etiopathogenesis and definition of chronic pancreatitis. Dig Dis Sci 31:91S-107S

    Article  PubMed  CAS  Google Scholar 

  14. Schmiegel W-H, Burchert M, Kalthoff H, Thiele HG, Bützow GH, Klose G, Greten H (1986) Pancreatic stone protein in serum of patients with pancreatitis. Lancet ii:686

    Article  Google Scholar 

  15. Bernard JP, Provansal-Cheylan M, Mariani A, Dupuy P, Sarles H (1989) Pancreatic stone protein: quantification in pancreatic juice by enzyme-linked immunosorbent assay and comparison with other methods. Gastroenterology 96:A955

    Google Scholar 

  16. Schmiegel W, Burchert M, Kalthoff H, Roeder C, Bützow G, Grimm H, Kremer B, Soehendra N, Schreiber H-W, Thiele H-G, Greten H (1990) Immunochemical characterization and quantitative distribution of pancreatic stone protein in sera and pancreatic secretions in pancreatic disorders. Gastroenterology 1421–1430

    Google Scholar 

  17. Montalto G, Bonicel J, Multigner L, Rovery M, Sarles H, De Caro A (1986) Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein. Biochem J 238:227–232

    PubMed  CAS  Google Scholar 

  18. Gross J, Brauer AW, Bringhurst RF, Corbett C, Margolies MN (1985) An unusual bovine pancreatic protein exhibiting pH-dependent globule-fibril transformation and unique amino acid sequence. Proc Natl Acad Sci USA 82:5627–5631

    Article  PubMed  CAS  Google Scholar 

  19. Neurath AR, Strick N (1981) Enyzme-linked fluorescence immunoassays using ß-galactosidase and antibodies covalently bound to polystyrene plates. J Virol Methods 3:155–165

    Article  PubMed  CAS  Google Scholar 

  20. Montalto G, Lusher M, De Caro A, Multigner L, Sarles H, Delaage M (1985) Analysis of human pancreatic juice constituents related to the pancreatic stone protein using monoclonal antibody. CR Acad Sci (Paris) 300:199–202

    CAS  Google Scholar 

  21. Provansal-Cheylan M, Lusher M, De Caro A, Multigner L, Montalto G, Sarles H, Delaage M (1986) Monoclonal antibodies to pancreatic stone protein. Radioimmunoassay and immunological comparison with trypsin 1. Biochimie 68:1109–1113

    Article  PubMed  CAS  Google Scholar 

  22. Schmiegel WH, Kreiker C, Eberl W, Arndt R, Classen M, Greten H, Jessen K, Kalthoff H, Soehendra N, Thiele HG (1985) Monoclonal antibody defines CA 19–9 in pancreatic juice and sera. Gut 26:456–460

    Article  PubMed  CAS  Google Scholar 

  23. Axon ATR, Classen M, Cotton PB, Cremer M, Freeny PC, Lees WR (1984) Pancreatography in chronic pancreatitis: international definitions. Gut 25: 1107–1112

    Article  PubMed  CAS  Google Scholar 

  24. Sarner M, Cotton PB (1984) Classification of pancreatitis. Gut 25:756–759

    Article  PubMed  CAS  Google Scholar 

  25. Sarles H, Gyr K, Singer MV (1984) Revised classification of pancreatitis- Marseille 1984. Presented at the American Pancreatic Association Meeting, 8 November, 1984, Chicago

    Google Scholar 

  26. De Caro A, Multigner L, Dagorn JC, Sarles H (1988) The human pancreatic stone protein. Biochimie 70:1209–1214

    Article  PubMed  Google Scholar 

  27. De Caro AM, Bonicel JJ, Rouimi P, De Caro JD, Sarles H, Rovery M (1987) Complete amino acid sequence of an immuno-reactive form of human pancreatic stone protein isolated from pancreatic juice. Eur J Biochem 168:201–207

    Article  PubMed  Google Scholar 

  28. Rouimi P, Bonicel J, Rovery M, De Caro A (1987) Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein. FEBS Lett 216:195–199

    Article  PubMed  CAS  Google Scholar 

  29. Klöppel G (1984) Pancreatic, non-endocrine tumours. In: Klöppel G, Heitz UP (eds) Pancreatic pathology. Edinburgh, pp 79–113

    Google Scholar 

  30. Sarles H, Dagorn JC, Giorgi D, Bernard JP (1990) Renaming pancreatic stone protein as “Lithostathine”. Gastroenterology 99:900–901

    PubMed  CAS  Google Scholar 

  31. Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, Okamoto H (1988) A novel gene activated in regenerating islets. J Biol Chem 263:2111–2114

    PubMed  CAS  Google Scholar 

  32. Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H (1990) Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. J Biol Chem 265:7432–7439

    PubMed  CAS  Google Scholar 

  33. Terazono K, Watanabe T, Yonemura Y (1990) A novel gene, reg, expressed in regenerating islets. In: Okamoto H (ed) Molecular biology of the islets of Langerhans. Cambridge University Press, Cambridge, pp 301–315

    Chapter  Google Scholar 

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Authors and Affiliations

  1. Medizinische Kernklinik und Poliklinik, Universitätskrankenhaus Eppendorf, Martinistraße 52, W-2000, Hamburg 20, Germany

    W. Schmiegel

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  1. W. Schmiegel
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Editors and Affiliations

  1. Abteilung für Allgemeine Chirurgie, Universitätsklinik Ulm, Steinhövelstraße 9, W-7900, Ulm, Germany

    H. G. Beger  & M. Büchler  & 

  2. Abteilung Innere Medizin II, Universitätsklinik Ulm, Robert-Koch-Straße 8, W-7900, Ulm, Germany

    P. Malfertheiner

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© 1993 Springer-Verlag Berlin Heidelberg

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Schmiegel, W. (1993). PSP, PTP, or REG Protein? The Role of Pancreatic Stone Protein. In: Beger, H.G., Büchler, M., Malfertheiner, P. (eds) Standards in Pancreatic Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77437-9_32

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  • DOI: https://doi.org/10.1007/978-3-642-77437-9_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77439-3

  • Online ISBN: 978-3-642-77437-9

  • eBook Packages: Springer Book Archive

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