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CMV prophylaxis after renal transplantation with immunoglobulin or CMV-hyperimmunoglobulin — a prospective clinical trial

  • D. Stippel
  • P. Wienand
  • N. Weißenberg
  • C. Baldamus
  • U. Kruppenbacher
Conference paper

Abstract

Three groups of 40 patients each entered this prospective randomized trial. Patients of group A received 2 ml/kg body weight CMV-Polyglobulin, patients of group B 15 g Intraglobin and patients of group C, serving as controls, received no specific anti-CMV prophylaxis. All patients were given the same sequential immunosuppressive therapy. Patient survival and graft function did not show any significant differences at 2 years follow up. The incidence of fever, CMV infections, dialysis and steroid bolus therapy were lower in group A, but without statistical significance. Patients receiving a graft from a CMV-AK-positive donor were at high risk of developing an infection or reactivation of CMV. A study examining this subgroup seems appropriate.

Key words

CMV prophylaxis Renal transplantation Immunoglobulin 

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • D. Stippel
    • 1
  • P. Wienand
    • 1
  • N. Weißenberg
    • 1
  • C. Baldamus
    • 2
  • U. Kruppenbacher
    • 3
  1. 1.Department of SurgeryUniversity of CologneCologneGermany
  2. 2.Department of Internal MedicineUniversity of CologneCologneGermany
  3. 3.Department of VirologyUniversity of CologneCologneGermany

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