Advertisement

The impact of ischemic lesions in the donor kidney, donor age, recipient age and HLA (A, B, C, DR, DQ) matching on clinical course after kidney grafting

  • M. H. L. Christiaans
  • H. G. Peltenburg
  • F. H. M. Niemann
  • G. Kootstra
  • A. T. J. Lavrijssen
  • P. M. van den Berg-Loonen
  • A. Tiebosch
  • K. M. L. Leunissen
  • J. P. van Hooff
Conference paper

Abstract

It is generally accepted that HLA matching improves graft survival [1]. However, there is no consensus on whether this improvement is reflected on daily clinical course. Clinical course after renal transplantation depends on many factors, such as donor age, recipient age, ischemic score in the kidney [2], and HLA matching [3]. The relative contribution of these factors is unknown. Because management of the recipients in the various centers differs considerably, only a single centre study would reveal the relative contribution of all these factors. Therefore, in our centre we studied the influence of these parameters on the clinical course after renal allografting.

Key words

Kidney transplantation Ischemic lesions Donor age Recipient age HLA matching 

References

  1. 1.
    Opelz G, Schwarz V, Engelmann A, Bach D, Wilk M, Keppel E (1991) Long-term impact of HLA matching on kidney graft survival in cyelosporine-treated recipients. Transplant Proc 23: 373–375PubMedGoogle Scholar
  2. 2.
    Leunissen KML, Bosman FT, Nieman FHM, Kootstra G, Vromen MAM, Noordzij TC, van Hooff JP (1989) Amplification of the nephrotoxic effect of cyclosporine by preexistent chronic histological lesions in the kidney. Transplantation 48:590–593PubMedGoogle Scholar
  3. 3.
    van Hooff JP, van Hooff-Eykenboom YEA, Kalff MW, de Graeff J, van Rood JJ (1979) Kidney graft survival, clinical course, and HLA-A, B and D matching in 208 patients transplanted in one center. Transplant Proc 11:1291–1292PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • M. H. L. Christiaans
    • 1
  • H. G. Peltenburg
    • 1
  • F. H. M. Niemann
    • 1
  • G. Kootstra
    • 2
  • A. T. J. Lavrijssen
    • 1
  • P. M. van den Berg-Loonen
    • 3
  • A. Tiebosch
    • 4
  • K. M. L. Leunissen
    • 1
  • J. P. van Hooff
    • 1
  1. 1.Department of Internal MedicineUniversity Hospital MaastrichtMaastrichtThe Netherlands
  2. 2.Department of SurgeryUniversity Hospital MaastrichtMaastrichtThe Netherlands
  3. 3.Department of Tissue TypingUniversity Hospital MaastrichtMaastrichtThe Netherlands
  4. 4.Department of PathologyUniversity Hospital MaastrichtMaastrichtThe Netherlands

Personalised recommendations