Flow cytometric crossmatching and outcome one year after renal transplantation

  • D. Talbot
  • B. K. Shenton
  • A. L. Givan
  • G. Cavanagh
  • G. Proud
  • R. M. R. Taylor
Conference paper

Abstract

Previous studies have shown that flow cytometric cross match assays can identify an at risk population in renal transplantation [1–5]. We used the assay for recipient selection for 1 year. Recipients with donor T cell directed IgG were excluded from transplantation and those with B cell directed IgG were treated with increased immunosuppressant. The transplants performed over this period (n = 126) were compared with an earlier series (n = 118) in which flow cytometric cross match results did not influence patient management. The results were evaluated for mortality and graft outcome at 3 months and 1 year. In addition, postoperative complications and duration of hospital stay were also assessed.

Key words

Flow cytometric crossmatching Renal transplantation Recipient selection 

References

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    Talbot D, Givan AL, Shenton BK, et al. (1989) Transplantation 47:552PubMedCrossRefGoogle Scholar
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    Talbot D, Givan AL, Shenton BK, et al. (1990) Transplantation 49:809PubMedCrossRefGoogle Scholar
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    Talbot D, Givan AL, Shenton B, et al. (1988) J Immunol Methods 112:279PubMedCrossRefGoogle Scholar
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    Thorogood J, van Houwelingen JC, van Rood JJ, et al. (1989) Transplantation 48:231PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • D. Talbot
    • 1
  • B. K. Shenton
    • 1
  • A. L. Givan
    • 1
  • G. Cavanagh
    • 1
  • G. Proud
    • 1
  • R. M. R. Taylor
    • 1
  1. 1.Departments of Surgery and Tissue TypingThe Medical School, University of Newcastle upon TyneUK

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