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Remarkable correlation between increased HLA-DQ antigen positive monocytes and prognosis of renal transplantation

  • Y. Fukuda
  • T. Ishikawa
  • H. Yahata
  • S. Marubayashi
  • K. Dohi
Conference paper

Abstract

Since cyclosporin A (CsA), a widely used immunosuppressive drug, strongly suppresses interleukin-2 (IL-2) secretion, it is frequently difficult to estimate T lymphocyte activation in early acute rejection. We found that, when evaluated based on HLA-DQ antigen expression, monocyte activation in the peripheral blood of renal transplantation patients was a very sharp parameter in diagosing acute rejection. All of 16 episodes of early acute rejection, which were relatively easily suppressed by steroid pulse therapy, showed a sharp increase in the proportion of HLA-DQ antigen-positive monocytes (DQ+mono) and a quick return of DQ+mono to previous values, along with a fall in serum creatinine levels. Since, however, HLA-DR antigen-positive T lymphocytes (DR+T) were markedly increased over a long period in episodes of therapy-resistant and chronic rejection, their prolonged high value was regarded as a parameter indicative of poor prognosis.

Key words

Immunological monitoring HLA-DQ positive monocytes Monocyte HLA-DQ antigen 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Y. Fukuda
    • 1
  • T. Ishikawa
    • 1
  • H. Yahata
    • 1
  • S. Marubayashi
    • 1
  • K. Dohi
    • 1
  1. 1.Second Department of SurgeryHiroshima University School of MedicineHiroshimaJapan

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