RS-61443 reverses acute renal allograft rejection in dogs

  • K.-P Platz
  • W. O. Bechstein
  • D. E. Eckhoff
  • D. A. Hullett
  • H. W. Sollinger
Conference paper

Abstract

RS-61443 is a noncompetitive allosteric inhibitor of inosine monophosphate dehydrogenase. At blocks the proliferative response of T and B lymphocytes, prevents the generation of cytotoxic T cells, and inhibits antibody formation. This study was conducted to see whether or not RS-61443 can reverse acute renal allograft rejection in dogs. At was possible to reverse this process.

Key words

RS-61443 Inosine monophosphate dehydrogenase Renal allografts Rejection Reversing rejection 

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • K.-P Platz
    • 1
  • W. O. Bechstein
    • 1
  • D. E. Eckhoff
    • 2
  • D. A. Hullett
    • 2
  • H. W. Sollinger
    • 2
  1. 1.Department of SurgeryRudolf Virchow University ClinicBerlinGermany
  2. 2.Department of SurgeryUniversity of Wisconsin School of MedicineMadisonUSA

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