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Transplant International Official Journal of the European Society for Organ Transplantation pp 542–543Cite as

RS-61443 reverses acute renal allograft rejection in dogs

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Abstract

RS-61443 is a noncompetitive allosteric inhibitor of inosine monophosphate dehydrogenase. At blocks the proliferative response of T and B lymphocytes, prevents the generation of cytotoxic T cells, and inhibits antibody formation. This study was conducted to see whether or not RS-61443 can reverse acute renal allograft rejection in dogs. At was possible to reverse this process.

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References

  1. Burlingham WJ, Grailer AP, Hullett DA, Sollinger HW (1991) Inhibition of both MLC and in vitro IgG memory response to tetanus toxoid by RS-61443. Transplantation 51:545–547

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  2. Eugui EM, Almquist SJ, Muller CD, Allison AC (1991) Lymphocyte-selective antiproliferative and immunosuppressive effects of mycophenolic acid. Scand J Immunol 33:161–173

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  3. Morris RE, Hoyt EG, Murphy MP, Eugui EM, Allison AC (1990) Mycophenolic acid morpholinoethylester (RS-61443) is a new immunosuppressant that prevents and halts heart allograft rejection by selective inhibition of T- and B-cell purine synthesis. Transplant Proc 22:1659–1662

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  4. Platz KP, Sollinger HW, Hullett DA, Eckhoff DE, Eugui EM, Allison AC (1991) RS-61443: a new, potent immunosuppressive agent. Transplantation 51:27–31

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Author information

Authors and Affiliations

  1. Department of Surgery, Rudolf Virchow University Clinic, Berlin, Germany

    K.-P Platz & W. O. Bechstein

  2. Department of Surgery, University of Wisconsin School of Medicine, Madison, Wisconsin, USA

    D. E. Eckhoff, D. A. Hullett & H. W. Sollinger

Authors
  1. K.-P Platz
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  2. W. O. Bechstein
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  3. D. E. Eckhoff
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  4. D. A. Hullett
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  5. H. W. Sollinger
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Editor information

Editors and Affiliations

  1. Department of Surgery, University Hospital, P.O.Box 5800, 6202 AZ, Maastricht, The Netherlands

    Gauke Kootstra

  2. Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, W-6900, Heidelberg, Germany

    Gerhard Opelz

  3. Department of Surgery, University of Limburg, (B. M. C.) Beeldsnijderdreef 101, NL-6216 EA, Maastricht, The Netherlands

    W. A. Buurman

  4. Department of Nephrology, University Hospital Maastricht, P. Debyelaan 25, NL-6202 AZ, Maastricht, The Netherlands

    J. P. van Hooff

  5. The Liver Unit, Queen Elizabeth Hospital, B152TH, Edgbaston, Birmingham, UK

    P. MacMaster

  6. Papworth Hospital, CB3 8RE, Papworth Everard, Cambridgeshire, UK

    J. Wallwork

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© 1992 Springer-Verlag Berlin Heidelberg

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Cite this paper

Platz, KP., Bechstein, W.O., Eckhoff, D.E., Hullett, D.A., Sollinger, H.W. (1992). RS-61443 reverses acute renal allograft rejection in dogs. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_159

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  • DOI: https://doi.org/10.1007/978-3-642-77423-2_159

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55342-7

  • Online ISBN: 978-3-642-77423-2

  • eBook Packages: Springer Book Archive

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