Multivisceral cluster transplantation in the rat

  • M. Knoop
  • R. Steffen
  • P. Neuhaus
Conference paper


Transplantation of multivisceral grafts has evolved recently as a new therapeutic modality for hepatopancreatobiliary malignancies [1, 2]. The mutual interactions between the liver, pancreas, small bowel and the recipient organism after cluster grafting are not clearly understood and deserve further experimental evaluation. We present a technique for combined hepatopancreaticoduodenal cluster transplantation in the rat. The cluster grafts consisted of a pancreaticoduodenal graft and an orthotopic arterialized liver graft. A separate arterial anastomosis of the liver and a bile duct anastomosis were not necessary. Bile and exocrine pancreas secretions drained over the duodenal conduit of the graft into the recipients jejunum via an end-to-side anastomosis.

Key words

Multivisceral grafts Hepatopancreaticoduodenal cluster transplantation Rat 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • M. Knoop
    • 2
  • R. Steffen
    • 1
  • P. Neuhaus
    • 1
  1. 1.Department of SurgeryFree University of BerlinBerlinGermany
  2. 2.University Hospital Rudolf VirchowBerlinGermany

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