Multivisceral cluster transplantation in the rat
Transplantation of multivisceral grafts has evolved recently as a new therapeutic modality for hepatopancreatobiliary malignancies [1, 2]. The mutual interactions between the liver, pancreas, small bowel and the recipient organism after cluster grafting are not clearly understood and deserve further experimental evaluation. We present a technique for combined hepatopancreaticoduodenal cluster transplantation in the rat. The cluster grafts consisted of a pancreaticoduodenal graft and an orthotopic arterialized liver graft. A separate arterial anastomosis of the liver and a bile duct anastomosis were not necessary. Bile and exocrine pancreas secretions drained over the duodenal conduit of the graft into the recipients jejunum via an end-to-side anastomosis.
Key wordsMultivisceral grafts Hepatopancreaticoduodenal cluster transplantation Rat