A Role for Interleukin-1 in Septic Shock

  • L. L. Moldawer
  • E. Fischer
  • K. Van Zee
  • W. A. Thompson
  • S. F. Lowry


Therapies that can reduce the morbidity and mortality of Gram negative septic shock offer great potential for treatment of the critically-ill patient. Septic shock secondary to Gram negative bacteremia or endotoxemia is characterized by hemodynamic collapse, hypercoagulopathy, multisystem organ failure and death. Despite supportive therapy, mortality still approximates 50%.


Septic Shock Mean Arterial Blood Pressure Sepsis Syndrome Hemodynamic Performance Leukocytic Infiltration 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • L. L. Moldawer
    • 1
  • E. Fischer
    • 1
  • K. Van Zee
    • 1
  • W. A. Thompson
    • 1
  • S. F. Lowry
    • 1
  1. 1.Laboratory of Surgical Metabolism, Department of SurgeryCornell University Medical CollegeNew YorkUSA

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