The Role of TNF in Gram-Negative Sepsis in Baboon

  • H. Redl
  • G. Schlag G
  • J. Davies
  • W. A. Buurman
  • M. Bodmer
Conference paper


During sepsis TNF message is expressed and the protein is released both locally and into plasma. Teleologically such cytokine response must be beneficial to the host. However, from a certain threshold level of activation there might be an overactivation and imbalance of the cytokine system, which then tends to be harmful to the host. Cytokines in sepsis occur in sequence, with possible reciprocal amplification or inhibition cascade.


Tumor Necrosis Factor Circ Shock Tumor Necrosis Factor Production Tumor Necrosis Factor Level Baboon Model 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • H. Redl
    • 1
  • G. Schlag G
    • 1
  • J. Davies
    • 2
  • W. A. Buurman
    • 3
  • M. Bodmer
    • 4
  1. 1.Ludwig Boltzmann Institute for Experimental and Clinical TraumatologyViennaAustria
  2. 2.Roodeplaat Research LaboratoriesPretoriaSouth Africa
  3. 3.Department of SurgeryUniversity of LimburgThe Netherlands
  4. 4.Molecular ImmunologyCelltechSloughUK

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