The Cellular Mechanisms of Tumor Necrosis Factor-Induced Mortality: A Possible Role for Platelet Activating Factor and/or the Eicosanoids
Tumor necrosis factor (TNF) is hailed as the seminal mediator in endotoxemia and/or sepsis in animals and humans [1, 2]. Of particular interest recently has been the reported role of eicosanoids (PGS) and platelet activating factor (PAF) in mediating many of the events in the pathophysiology of endotoxemia/sepsis in animals [3, 4]. Interestingly, the putative effects of PAF and the eicosanoids alone or in endotoxemia/sepsis are very similar to those attributed to TNF. To make the situation even more complex, TNF stimulates endothelial cells or fibroblasts to synthesize PAF , prostacyclin , or PGE2  as well as many other potent cellular effectors.
KeywordsTumor Necrosis Factor Metabolic Acidosis Platelet Activate Factor Cyclooxygenase Inhibitor Histological Abnormality
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Beutler BA, Melsark IW, Cerami A (1985) Science 229:869–871PubMedCrossRefGoogle Scholar
Waage A, Holstensen A, Espevik T (1987) Lancet 1:355–357PubMedCrossRefGoogle Scholar
Fletcher JR, DiSimone AG, Earnest M (1990) Ann Surg 211:312–316PubMedGoogle Scholar
Moore JA, Earnest MA, DiSimone AG, Abumrad NN, Fletcher JR (1991) Circ Shock (in press)Google Scholar
Camussi G, Bussolino F, Salvidio G, Baglioni C (1987) J Exp Med 166:1390–1404PubMedCrossRefGoogle Scholar
Kawakami M, Ishibashi S, Ogawa H, Murase T, Takaku F (1986) Biochem Biophys Res Commun 141:482–487PubMedCrossRefGoogle Scholar
Oayer JM, Beutler B, Cerami A (1985) J Exp Med 162:2163–2168CrossRefGoogle Scholar
Kettelhut IC, Fiers W, Goldberg AL (1987) Proc Natl Acad Sci USA 84:4273–4277PubMedCrossRefGoogle Scholar
Fletcher JR (1985) Biological protection with prostaglandins, vol 1. CRC, Boca Raton, pp 65–72Google Scholar
Talmadge JE, Bowersox O, Tribble H, Lee SH, Shepard HM, Ligitt D (1987) Am J Pathol 128:410–425PubMedGoogle Scholar
Evans DA, Jacobs DO, Revhaug A, Wilmore DW (1989) Ann Surg 204:312–321CrossRefGoogle Scholar
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