Increased Leukocyte Adhesion in Liver Sinusoids Following Superior Mesenteric Artery Occlusion in the Rat

  • V. Bühren
  • B. Maier
  • R. Hower
  • M. D. Menger
  • I. Marzi

Abstract

Endotoxemia and bacterial translocation due to an injured mucosal barrier may occur following shock or vascular occlusion due to an intestinal ischemia/reperfusion injury [1, 2]. It has been suggested that this sequence of events contributes to the development of multiple organ failure after shock and trauma [3–5]. The importance of gut-derived toxins (e.g., endotoxin) in inducing the release of cytokines such as TNF-α or other inflammatory mediators is well known [6, 7]. However, the precise sequence of pathophysiological events taking place in the liver due to intestinal reperfusion injury has not been completely elucidated.

Keywords

Ischemia Attenuation Superoxide Fluor Peri 

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • V. Bühren
    • 1
  • B. Maier
    • 1
  • R. Hower
    • 1
  • M. D. Menger
    • 1
  • I. Marzi
    • 1
  1. 1.Department of Trauma SurgeryUniversity of SaarlandHomburg/SaarGermany

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