Increased Leukocyte Adhesion in Liver Sinusoids Following Superior Mesenteric Artery Occlusion in the Rat
Endotoxemia and bacterial translocation due to an injured mucosal barrier may occur following shock or vascular occlusion due to an intestinal ischemia/reperfusion injury [1, 2]. It has been suggested that this sequence of events contributes to the development of multiple organ failure after shock and trauma [3–5]. The importance of gut-derived toxins (e.g., endotoxin) in inducing the release of cytokines such as TNF-α or other inflammatory mediators is well known [6, 7]. However, the precise sequence of pathophysiological events taking place in the liver due to intestinal reperfusion injury has not been completely elucidated.
KeywordsMean Arterial Blood Pressure Leukocyte Adhesion Liver Sinusoid Adherent Leukocyte Superior Mesenteric Artery Occlusion
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