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Increased Leukocyte Adhesion in Liver Sinusoids Following Superior Mesenteric Artery Occlusion in the Rat

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Host Defense Dysfunction in Trauma, Shock and Sepsis

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Abstract

Endotoxemia and bacterial translocation due to an injured mucosal barrier may occur following shock or vascular occlusion due to an intestinal ischemia/reperfusion injury [1, 2]. It has been suggested that this sequence of events contributes to the development of multiple organ failure after shock and trauma [3–5]. The importance of gut-derived toxins (e.g., endotoxin) in inducing the release of cytokines such as TNF-α or other inflammatory mediators is well known [6, 7]. However, the precise sequence of pathophysiological events taking place in the liver due to intestinal reperfusion injury has not been completely elucidated.

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Authors and Affiliations

  1. Department of Trauma Surgery, University of Saarland, D-6650, Homburg/Saar, Germany

    V. Bühren, B. Maier, R. Hower, M. D. Menger & I. Marzi

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  1. V. Bühren
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  2. B. Maier
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  3. R. Hower
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  4. M. D. Menger
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  5. I. Marzi
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Editor information

Editors and Affiliations

  1. Dept. of Surgery, Ludwig-Maximilians-University Munich, Klinikum Großhadern Marchioninistr. 15, 8000, Munich 70, Germany

    Eugen Faist  & Friedrich W. Schildberg  & 

  2. Dept. of Surgery, McGill University, Room 510.34 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada

    Jonathan L. Meakins M.D., D.Sc.

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© 1993 Springer-Verlag, Berlin Heidelberg

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Bühren, V., Maier, B., Hower, R., Menger, M.D., Marzi, I. (1993). Increased Leukocyte Adhesion in Liver Sinusoids Following Superior Mesenteric Artery Occlusion in the Rat. In: Faist, E., Meakins, J.L., Schildberg, F.W. (eds) Host Defense Dysfunction in Trauma, Shock and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77405-8_69

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  • DOI: https://doi.org/10.1007/978-3-642-77405-8_69

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77407-2

  • Online ISBN: 978-3-642-77405-8

  • eBook Packages: Springer Book Archive

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