Ischemia-Reperfusion Injury of the Liver: Role of Neutrophils and Xanthine Oxidase
Reperfusion of tissues after a period of ischemia is known to result in microvascular and endothelial injury. In this context activated neutrophils and xanthine oxidase have been suggested to play a major pathogenic role in a variety of inflammatory reactions associated with ischemia-reperfusion events . Recent studies on ischemia-reperfusion have focused on the microcirculation, the primary target for leukocyte accumulation, leukocyte-endothelium interaction, and generation of oxygen-derived free radicals [2–4].
KeywordsIschemia Superoxide Adenosine Histamine Xanthine
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