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Ischemia-Reperfusion Injury of the Liver: Role of Neutrophils and Xanthine Oxidase

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Host Defense Dysfunction in Trauma, Shock and Sepsis

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Abstract

Reperfusion of tissues after a period of ischemia is known to result in microvascular and endothelial injury. In this context activated neutrophils and xanthine oxidase have been suggested to play a major pathogenic role in a variety of inflammatory reactions associated with ischemia-reperfusion events [1]. Recent studies on ischemia-reperfusion have focused on the microcirculation, the primary target for leukocyte accumulation, leukocyte-endothelium interaction, and generation of oxygen-derived free radicals [2–4].

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Author information

Authors and Affiliations

  1. Institute for Surgical Research, University of Munich, Chirurgische Forschung, LMU München, Marchioninistr. 15,8000, München 70, Germany

    M. D. Menger & K. Messmer

  2. Department of General Surgery, University of Saarland, Homburg/Saar, Germany

    M. J. Müller

  3. Department of Trauma Surgery, University of Zurich, Switzerland

    H. P. Friedl & O. Trentz

Authors
  1. M. D. Menger
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  2. M. J. Müller
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  3. H. P. Friedl
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  4. O. Trentz
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  5. K. Messmer
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Editor information

Editors and Affiliations

  1. Dept. of Surgery, Ludwig-Maximilians-University Munich, Klinikum Großhadern Marchioninistr. 15, 8000, Munich 70, Germany

    Eugen Faist  & Friedrich W. Schildberg  & 

  2. Dept. of Surgery, McGill University, Room 510.34 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada

    Jonathan L. Meakins M.D., D.Sc.

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© 1993 Springer-Verlag, Berlin Heidelberg

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Menger, M.D., Müller, M.J., Friedl, H.P., Trentz, O., Messmer, K. (1993). Ischemia-Reperfusion Injury of the Liver: Role of Neutrophils and Xanthine Oxidase. In: Faist, E., Meakins, J.L., Schildberg, F.W. (eds) Host Defense Dysfunction in Trauma, Shock and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77405-8_62

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  • DOI: https://doi.org/10.1007/978-3-642-77405-8_62

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77407-2

  • Online ISBN: 978-3-642-77405-8

  • eBook Packages: Springer Book Archive

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