Ischemia-Reperfusion Injury of the Liver: Role of Neutrophils and Xanthine Oxidase

  • M. D. Menger
  • M. J. Müller
  • H. P. Friedl
  • O. Trentz
  • K. Messmer


Reperfusion of tissues after a period of ischemia is known to result in microvascular and endothelial injury. In this context activated neutrophils and xanthine oxidase have been suggested to play a major pathogenic role in a variety of inflammatory reactions associated with ischemia-reperfusion events [1]. Recent studies on ischemia-reperfusion have focused on the microcirculation, the primary target for leukocyte accumulation, leukocyte-endothelium interaction, and generation of oxygen-derived free radicals [2–4].


Xanthine Oxidase Xanthine Oxidase Activity Microvascular Blood Flow Leukocyte Accumulation Postischemic Reperfusion 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • M. D. Menger
    • 1
  • M. J. Müller
    • 2
  • H. P. Friedl
    • 3
  • O. Trentz
    • 3
  • K. Messmer
    • 1
  1. 1.Institute for Surgical ResearchUniversity of Munich, Chirurgische Forschung, LMU MünchenMünchen 70Germany
  2. 2.Department of General SurgeryUniversity of SaarlandHomburg/SaarGermany
  3. 3.Department of Trauma SurgeryUniversity of ZurichSwitzerland

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