Decrease in Leukotriene Synthesis from Leukocytes Isolated in Septic Patients
Many experimental and clinical investigations support the hypothesis that the leukotrienes are likely contributors to the nonhydrostatic edema associated with organ damage in sepsis [1–8]. In this study the capacity of leukocytes to synthesize leukotrienes was measured. The production of leukotriene C4 (LTC4) from leukocytes isolated in septic patients was compared to the values obtained in healthy volunteers.
KeywordsSeptic Patient Bronchoalveolar Lavage Fluid Adult Respiratory Distress Syndrome Acute Physiologic Score Pulmonary Failure
Unable to display preview. Download preview PDF.
- 4.Brigham K, Sheller J (1989) Leukotrienes and ARDS Intensive Care Med 15:422–423Google Scholar
- 13.Kopprash S, Hörkner U, Orlik H et al. (1989) Energy state, glycolytic intermediates and mitochondrial function in the liver during reversible and irreversible endotoxin shock. Biomed Biochim Acta 48:653–659Google Scholar
- 18.Rossignon M, Khayat D, Royer C, Pouby J et al. (1990) Functional and metabolic activity of polymorphonuclear leukocytes from patients with adult respiratory distress syndrome: results of a randomized double-blind placebo-controlled study on the activity of prostaglandin E1. Anesthesiology 72:276–281PubMedCrossRefGoogle Scholar