Decrease in Leukotriene Synthesis from Leukocytes Isolated in Septic Patients

  • H. Lessire
  • B. Miele
  • M. Pfisterer
  • T. N. Nguyen
  • E. Torwesten
  • C. Puchstein
  • B. M. Peskar


Many experimental and clinical investigations support the hypothesis that the leukotrienes are likely contributors to the nonhydrostatic edema associated with organ damage in sepsis [1–8]. In this study the capacity of leukocytes to synthesize leukotrienes was measured. The production of leukotriene C4 (LTC4) from leukocytes isolated in septic patients was compared to the values obtained in healthy volunteers.


Septic Patient Bronchoalveolar Lavage Fluid Adult Respiratory Distress Syndrome Acute Physiologic Score Pulmonary Failure 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • H. Lessire
    • 1
  • B. Miele
    • 1
  • M. Pfisterer
    • 1
  • T. N. Nguyen
    • 1
  • E. Torwesten
    • 1
  • C. Puchstein
    • 1
  • B. M. Peskar
    • 2
  1. 1.Klinik für Anästhesiologie und operative Intensivmedizin, Marienhospital Herne 1Ruhr-Universität BochumHerne 1Germany
  2. 2.Abteilung fur Experimentelle Klinische MedizinRuhruniversität Bochum 1Germany

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