Role of Oxygen Radicals in Multiple Organ Failure

  • H. P. Friedl
  • O. Trentz
  • G. O. Till
  • P. A. Ward


Multiple organ failure (MOF) has become a recognized disease entity occurring in response to infection, vascular perfusion deficits, a persistent inflammatory focus, or a persistent focus of dead and/or injured tissue. At least four phases (shock, resuscitation, hypermetabolism and evidence of multiple organ failure) can be identified clinically. With MOF, the general pattern of the inflammatory response appears to be expressed both locally and systemically with the demonstrated changes of vascular permeability followed by exudation and the sequence of cell infiltrates characteristic of inflammation and, finally, the onset of repair mechanisms. A number of mechanisms appear to be associated with pathways leading to irreversible structural injury of metabolic disfuntion at the cell level (Fig. 1)


Xanthine Oxidase Multiple Organ Failure Supernatant Fluid Xanthine Dehydrogenase Zymosan Particle 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • H. P. Friedl
    • 1
  • O. Trentz
    • 1
  • G. O. Till
    • 2
  • P. A. Ward
    • 2
  1. 1.Departement Chirurgie, Klinik für UnfallchirurgieUniversitätsspital ZürichZürichSwitzterland
  2. 2.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA

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