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Diagnostic Role of New Mediators and Markers of Inflammation in Multiple Injured Patients

  • D. Nast-Kolb
  • C. Waydhas
  • M. Jochum
  • M. Spannagl
  • W. Machleidt
  • K. H. Duswald
  • L. Schweiberer

Abstract

The major cause of late death after severe blunt trauma is (multiple) organ failure (OF), which is a direct consequence of mediators released during primary tissue damage and circulatory shock. To further elucidate the role of inflammatory mediators in the development of OF we performed a prospective study in severely injured patients. In a second step we examined the early prognostic value of objective biochemical markers for death and the development of OF compared to the Injury Severity Score (ISS).

Keywords

Organ Failure Injury Severity Score Disseminate Intravascular Coagulation Adult Respiratory Distress Syndrome Lethal Outcome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • D. Nast-Kolb
    • 1
  • C. Waydhas
    • 1
  • M. Jochum
    • 2
  • M. Spannagl
    • 3
  • W. Machleidt
    • 4
  • K. H. Duswald
    • 1
  • L. Schweiberer
    • 1
  1. 1.Chirurgische Klinik und PoliklinikKlinikum Innenstadt der Universität MünchenMunich 2Germany
  2. 2.Abteilung für Klinische Chemie und Klinische Biochemie, Chirurgische Klinik und PoliklinikKlinikum der Universität MünchenMunich 2Germany
  3. 3.Medizinische KlinikKlinikum Innenstadt der Universität MünchenMunich 2Germany
  4. 4.Institut für Physiologische ChemiePhysikalische Biochemie und Zellbiologie der Universität MünchenMunich 2Germany

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