The Role of β2-Leukocyte Integrins In Vivo

  • S. R. Sharar
  • N. B. Vedder
  • W. J. Mileski
  • C. L. Rice
  • J. M. Harlan
  • R. K. Winn

Abstract

The acute inflammatory response is characterized by the destructive activity of leukocytes against foreign pathogens and/or host tissue. In the event of bacterial invasion, leukocytes are directed to the site of infection by the release of soluble chemotactic agents. Leukocyte localization to the appropriate endothelium results from adherence to endothelial cells, followed by subsequent migration to the site of infection. Leukocytes phagocytose the invading bacteria and release toxic products (e.g., oxygen radicals, proteases) into phagosomes to act against the invading pathogens to protect the host. In noninfectious conditions such as ischemia-reperfusion injury, leukocytes may release these same substances into surrounding tissue causing destruction to the host. This process can occur when activated leukocytes becoming adherent to endothelial cells form a protected microenvironment at the cell-cell interface. This region is relatively inaccessible to plasma inhibitors of toxic leukocyte products (e.g., antioxidants and antiproteases), resulting in direct endothelial cell injury by these leukocyte products, loss of vascular integrity, tissue edema, and thrombosis.

Keywords

Permeability Migration Peroxi Ischemia Urea 

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • S. R. Sharar
    • 1
  • N. B. Vedder
    • 1
  • W. J. Mileski
    • 1
  • C. L. Rice
    • 1
  • J. M. Harlan
    • 1
  • R. K. Winn
    • 1
  1. 1.Departments of Anesthesiology, Surgery, Medicine, and Physiology-BiophysicsUniversity of Washington, Harborview Medical CenterSeattleUSA

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