Murine Intraabdominal Abscess: Immune Modulation with Interferon-γ

  • S. Galandiuk
  • S. Appel
  • J. D. Pietsch
  • W. G. Cheadle
  • H. C. PolkJr.

Abstract

Investigations in our laboratory have focused on changes in major histocompatibility complex (MHC) antigen expression on monocytes occurring in association with injury and clinical infection [1]. Expression of class II MHC antigens on the surface of monocytes appears to be essential for antigen recognition and T-cell proliferation [2].

Keywords

Interferon Fluore Paraformaldehyde Fluorescein FITC 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Polk HC Jr, George CD, Wellhausen SR, Cost K, Davidson PR, Regan MP, Borzotta AR (1986) A systematic study of host defense processes in badly injured patients. Ann Surg 204:282–299PubMedGoogle Scholar
  2. 2.
    Unanue ER (1984) Antigen-presenting function of the macrophage. Annu Rev Immunol 2:395–428PubMedCrossRefGoogle Scholar
  3. 3.
    Faist E, Mewes A, Strasser G, Walz A, Alkan S, Baker C, Ertel W, Heberer G (1988) Alteration of monocyte function following major injury. Arch Surg 123:287–292PubMedCrossRefGoogle Scholar
  4. 4.
    Hershman MJ, Cheadle WG, Wellhausen SR, Davidson PR, Polk HC Jr (1990) Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br J Surg 77:204–207PubMedCrossRefGoogle Scholar
  5. 5.
    Livingston DH, Appel SA, Wellhausen SR, Sonnenfeld G, Polk HC Jr (1988) Depressed interferon gamma production and monocyte HLA-DR expression after severe injury. Arch Surg 123:1309–1312PubMedCrossRefGoogle Scholar
  6. 6.
    Hershman MJ, Appel SA, Wellhausen SR, Polk HC Jr (1989) Interferongamma increases HLA-DR expression on monocytes in severely injured patients. Clin Exp Immunol 77:67–70PubMedGoogle Scholar
  7. 7.
    Hershman MJ, Polk HC Jr., Peitsch JD, Kuftinec D, Sonnenfeld G (1988) Modulation of Klebsiella pneumoniae infection of mice by interferon-gamma. Clin Exp Immunol 72:406–409PubMedGoogle Scholar
  8. 8.
    Hershman MJ, Sonnenfeld G, Mays BW, Fleming F, Trachtenberg LS, Polk HC Jr (1988) Effects of interferon-gamma treatment on surgically simulated wound infection in mice. Microb Pathog 4:165–168PubMedCrossRefGoogle Scholar
  9. 9.
    Hershman MJ, Sonnenfeld G, Logan WA, Pietsch JD, Wellhausen SR, Polk HC Jr (1988) Effect of interferon-gamma treatment of the course of a burn wound infection. J. Interferon Res 8:367–373PubMedCrossRefGoogle Scholar
  10. 10.
    Hershman MJ, Polk HC Jr, Pietsch JD, Shields RE, Wellhausen SR, Sonnenfeld G (1988) Modulation of infection by gamma interferon treatment following trauma. Infect Immun 56:2412–2416PubMedGoogle Scholar
  11. 11.
    Baker CC, Chaudry IH, Gaines HO, Baue AE (1983) Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 94:331–335PubMedGoogle Scholar
  12. 12.
    Beller DI, Springer TA, Schreiber RD (1982) Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor. J Exp Med 156:1000–1009PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • S. Galandiuk
    • 1
  • S. Appel
    • 1
  • J. D. Pietsch
    • 1
  • W. G. Cheadle
    • 1
  • H. C. PolkJr.
    • 1
  1. 1.Department of SurgeryUniversity of LouisvilleLouisvilleUSA

Personalised recommendations