Manipulation of Cytokine Synthesis Through Dietary Lipids

  • S. Endres
  • S. N. Meydani
  • C. A. Dinarello


Aside from its pyrogenic effects, interleukin-1 (IL-1) influences a wide array of biological functions (reviewed in [1]). Originally described in purified material from monocyte supernatants, most effects have been confirmed using recombinant IL-1 [2], To date the only known pharmacologic agents to reduce IL-1 synthesis are corticosteroids and cyclosporin A. We have completed a study to investigate whether dietary supplementation with n-3 fatty acids contained in fish oils affects the synthesis of IL-1 and tumor necrosis factor (TNF) [3]. The main forms of n-3 fatty acids are eicosapentaenoic acid and docosahexaenoic acid. They are scarce in a normal Western diet but occur in significant amounts in marine oils.


Cytokine Synthesis Fatty Acid Supplementation Human Tumor Necrosis Factor Alpha Human Blood Mononuclear Cell Kupffer Cell Function 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • S. Endres
    • 1
  • S. N. Meydani
    • 2
  • C. A. Dinarello
    • 3
  1. 1.Medizinische KlinikKlinikum Innenstadt der Universität MünchenMunich 2Germany
  2. 2.USDA Human Nutrition Research Center on AgingTufts University, New England Medical CenterBostonUSA
  3. 3.Department of MedicineTufts University, New England Medical CenterBostonUSA

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