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Manipulation of Cytokine Synthesis Through Dietary Lipids

  • S. Endres
  • S. N. Meydani
  • C. A. Dinarello

Abstract

Aside from its pyrogenic effects, interleukin-1 (IL-1) influences a wide array of biological functions (reviewed in [1]). Originally described in purified material from monocyte supernatants, most effects have been confirmed using recombinant IL-1 [2], To date the only known pharmacologic agents to reduce IL-1 synthesis are corticosteroids and cyclosporin A. We have completed a study to investigate whether dietary supplementation with n-3 fatty acids contained in fish oils affects the synthesis of IL-1 and tumor necrosis factor (TNF) [3]. The main forms of n-3 fatty acids are eicosapentaenoic acid and docosahexaenoic acid. They are scarce in a normal Western diet but occur in significant amounts in marine oils.

Keywords

Cytokine Synthesis Fatty Acid Supplementation Human Tumor Necrosis Factor Alpha Human Blood Mononuclear Cell Kupffer Cell Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • S. Endres
    • 1
  • S. N. Meydani
    • 2
  • C. A. Dinarello
    • 3
  1. 1.Medizinische KlinikKlinikum Innenstadt der Universität MünchenMunich 2Germany
  2. 2.USDA Human Nutrition Research Center on AgingTufts University, New England Medical CenterBostonUSA
  3. 3.Department of MedicineTufts University, New England Medical CenterBostonUSA

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