Host Defense Dysfunction in Trauma, Shock and Sepsis pp 1013-1016 | Cite as
Manipulation of Cytokine Synthesis Through Dietary Lipids
Aside from its pyrogenic effects, interleukin-1 (IL-1) influences a wide array of biological functions (reviewed in ). Originally described in purified material from monocyte supernatants, most effects have been confirmed using recombinant IL-1 , To date the only known pharmacologic agents to reduce IL-1 synthesis are corticosteroids and cyclosporin A. We have completed a study to investigate whether dietary supplementation with n-3 fatty acids contained in fish oils affects the synthesis of IL-1 and tumor necrosis factor (TNF) . The main forms of n-3 fatty acids are eicosapentaenoic acid and docosahexaenoic acid. They are scarce in a normal Western diet but occur in significant amounts in marine oils.
KeywordsCytokine Synthesis Fatty Acid Supplementation Human Tumor Necrosis Factor Alpha Human Blood Mononuclear Cell Kupffer Cell Function
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