Protein Synthesis Inhibitors and Bacterial Susceptibility to Phagocytosis
It is well recognised that antibiotics can be either bactericidal or bacteriostatic and on this basis their therapeutic efficacy can be measured. In particular those drugs in the latter category may depend upon the underlying activity of the host’s reticulo-endothelial system (RES) in order to demonstrate their full efficacy. Antibiotics whose mode of action is based upon bacterial ribosomal protein biosynthesis are usually bacteriostatic, and this article will concentrate on their bioactivity in concert with phagocytic cells.
KeywordsProtein Synthesis Inhibitor Fusidic Acid Polymorphonuclear Leucocyte Subinhibitory Concentration Bacterial Susceptibility
Unable to display preview. Download preview PDF.
- 1.Bassaris HP, Lianou PE, Papavassiliou JT (1988) Interaction of subminimal inhibitory concentrations of clindamycin and Escherichia coli: effects on adhesion and polymorphonuclear leukocyte function. J Antimicrob Chemother, Suppl B:25–32Google Scholar
- 2.Cialdella JI, Vavra JJ, Marshall VP (1986) Susceptibility of bacteria to serum lysis or phagocytosis following growth in subinhibitory levels of lincosaminide or spectinomycin related antibiotics. J Antibiot (Tokyo) 39:978–984Google Scholar
- 3.Gemmell CG (1985) Elaboration of structural and soluble virulence factors by antibiotic-damaged bacteria: consequences for host defences. Zentralbl Bakteriol Mikrobiol Hyg [A] 3, Suppl I 179–189Google Scholar
- 6.Gemmell CG, Peterson PK, Schemling D, Quie PG (1982) Studies on the potentiation of phagocytosis of Streptococcus pyogenes by treatment with various antibiotics. Drugs Exp Clin Res. 8:235–240Google Scholar
- 15.Veringa E, Verhoef J (1985) Influence of subinhibitory concentrations of clindamycin on the phagocytosis of Staphylococcus aureus. In: Adam D, Hahn H, Opferkuch W (eds) Influence of antibiotics on the host-parasite relationship. Springer, Berlin Heidelberg New York, pp 259–266Google Scholar