Role of Oxidants, Proinflammatory Agents, and Granulocytes in the Post Ischemic Intestine

  • P. Kubes
  • D. N. Granger

Abstract

In 1981, it was first postulated that xanthine oxidase (XO)-derived oxidants play an integral role in the microvascular injury associated with the reperfusion of ischemic tissue [1]. Since that time much work has been done to substantiate this hypothesis and to further expand on the pathophysiological alterations associated with ischemia-reperfusion (I/R). Figure 1 illustrates that during ischemia, cellular adenosine triphosphate (ATP) is converted to the catabolic substrate hypoxanthine while the enzyme xanthine dehydrogenase (XD) is converted to XO. Following reperfusion, oxygen reacts with hypoxanthine and XO to produce superoxide and hydrogen peroxide. These reactive oxygen metabolites may then be converted to the highly cytotoxic hydroxyl radical by the ironcatalyzed Haber-Weiss reaction. This initiates the process of lipid peroxidation which may stimulate the release of chemoattractants and the subsequent activation and recruitment of granulocytes. The objective of this chapter is to summarize supportive evidence regarding each component of the scheme presented in Fig. 1.

Keywords

DMSO Aldehyde Molybdenum Histamine Prostaglandin 

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1993

Authors and Affiliations

  • P. Kubes
  • D. N. Granger

There are no affiliations available

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