Characteristics of Neutrophil Dysfunction
Overwhelming sepsis is a major source of morbidity and mortality in patients following severe thermal injury or other traumatic injury. Despite this fact, the mechanisms underlying these potentially fatal complications have not been elucidated. It is likely that at least some of these altered immunological parameters are associated with infections and sepsis. Several lines of investigation have implicated neutrophil dysfunction as one of the major causes of increased infection rates in groups of patients. Since that time several reports have established a relationship between abnormal neutrophil functions and the development of life-threatening infections , whereas other investigators have failed to find high correlations between the defects and patient mortality [2, 3]. However, several laboratories, including our own, have found a significant correlation between the degree of the neutrophil dysfunction and the morbidity of the patient [4, 5].
KeywordsIntegrin Hunt Fluorescein Phenyl Alanine Biotin
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