Characteristics of Neutrophil Dysfunction
Overwhelming sepsis is a major source of morbidity and mortality in patients following severe thermal injury or other traumatic injury. Despite this fact, the mechanisms underlying these potentially fatal complications have not been elucidated. It is likely that at least some of these altered immunological parameters are associated with infections and sepsis. Several lines of investigation have implicated neutrophil dysfunction as one of the major causes of increased infection rates in groups of patients. Since that time several reports have established a relationship between abnormal neutrophil functions and the development of life-threatening infections , whereas other investigators have failed to find high correlations between the defects and patient mortality [2, 3]. However, several laboratories, including our own, have found a significant correlation between the degree of the neutrophil dysfunction and the morbidity of the patient [4, 5].
KeywordsTrauma Patient Thermal Injury Total Body Surface Area Neutrophil Phagocytosis Neutrophil Dysfunction
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- 8.Davis J, Dineen P, Gallin J (1980) Neutrophil degranulation and abnormal Chemotaxis after thermal injury. Annu Rev Med 124:1467–1471Google Scholar
- 30.White-Owen C, Babcock GF, Sramkoski RM, Alexander JW (1991) A rapid whole blood microassay for human neutrophil phagocytosis of FITC-labeled Staphylococcus aureus using flow cytometry. (submitted for publication)Google Scholar
- 32.White-Owen C, Alexander JW, Babcock GF (1991) Reduced expression of neutrophil CD11b and CD16 after severe trauma. J Surg Res (in Press)Google Scholar
- 33.White-Owen C, Babcock GF, Alexander JW (1990) Identification of a subpopulation of human neutrophils with altered phagocytic capacity in patients suffering severe thermal or traumatic injury. 6th International Symposium on Infections in the Immunocompromised Host 6:175 (Abstract)Google Scholar
- 34.White-Owen C, Alexander JW, Babcock GF (1990) Phagocytosis by CD11b-CD16- neutrophils. J Leukocyte Biol 1 [Suppl]:48Google Scholar