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Control of Growth Factors and Prevention of Cancer pp 15–26Cite as

Steroids, Retinoids, and their Mode of Action

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Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

The molecular understanding of biological systems which regulate patterns of gene expression both during the development of eucaryotic organisms and in terminally differentiated cells is a prerequisite for the design of strategies interfering with pathological situations that originate from deregulated gene expression. Our laboratory has been particularly interested in the transcriptional regulation by small signalling molecules of gene networks triggering development and homeostasis. In one of these signal transduction pathways the key molecule is a nuclear receptor for the signal and acts as an inducible transcription factor (Fig. 1). Initially, nuclear receptors comprised only some steroid hormone receptors, but we now recognise them as a superfamily of receptors for a variety of ligands, including steroids, thyroids and retinoids (Fig. 2). Moreover, due to their sequence similarity with known members of the family, a variety of “orphan” nuclear receptors have been cloned for which no [5–9], or only artificial ligands, such as peroxisome proliferators [10], are known. All of these receptors are characterised by a common structural organisation, first recognised in a comparison of the oestrogen receptors of various species [11]. The amino-acid sequence of a nuclear receptor is now generally divided into 7 segments, denoted A through F (Figs. 2 and 3).

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Authors and Affiliations

  1. Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de I’ INSERM, Institut de Chimie Biologique, Faculté de Médecine, 11 rue Humann, 67085, Strasbourg-Cédex, France

    Hinrich Gronemeyer & Pierre Chambon

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  1. Hinrich Gronemeyer
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  2. Pierre Chambon
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Editors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, Building 41, Room C-629, 20892, Bethesda, MD, USA

    Michael B. Sporn

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© 1992 Springer-Verlag Berlin Heidelberg

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Gronemeyer, H., Chambon, P. (1992). Steroids, Retinoids, and their Mode of Action. In: Sporn, M.B. (eds) Control of Growth Factors and Prevention of Cancer. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77383-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-77383-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77385-3

  • Online ISBN: 978-3-642-77383-9

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