Infections

  • H. Willenegger

Abstract

Since the work of Jack Burke (1961), it has been clearly established that true prophylaxis in surgical patients means preoperative administration of the prophylactic agent in such a way that all tissues encountered during surgery will have a therapeutic level of the agent present. This clearly means that true prophylaxis can only be applied in elective surgery or — with regard to fractures — when deciding to operate on a closed fracture.

Keywords

Placebo Hunt Staphylococcus Cephalosporin Osteomyelitis 

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References

  1. Boyd RJ, Burke JF, Colton T (1973) A double-blind clinical trial of prophylactic antibiotics in hip fracture. J Bone Joint Surg [Am] 55:1251–1254PubMedGoogle Scholar
  2. Burke JF (1961) The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery 50:161–168PubMedGoogle Scholar
  3. Carlsson AS, Lidgren L, Lindberg L (1977) Prophylactic antibiotics. Acta Orthop Scand 48:405–409PubMedCrossRefGoogle Scholar
  4. Cushing RD (1977) Antibiotics in trauma. Surg Clin North Am 57:165–177PubMedGoogle Scholar
  5. De Piro JT, Bowden TA, Hooks VH (1984) Prophylactic parenteral cephalosporins in surgery. JAMA 252:3277–3282CrossRefGoogle Scholar
  6. Geroulanos S, Lüthy R, Turina M, Largiadèr F, Senning A (1985) Antibiotikaprophylaxe in der Chirurgie. Helv Chir Acta 52:149–158PubMedGoogle Scholar
  7. Guglielmo BJ, Hohn DC, Roo PJ, Hunt TK, Sweet RL, Conte JE (1983) Antibiotic prophylaxis in surgical procedures. A critical analysis of the literature. Arch Surg 118:943–955PubMedCrossRefGoogle Scholar
  8. Hell K (1988) Half-life of antibiotics — an important factor in surgical single-dose prophylaxis. In: Hell K, Hobsley M (eds) Antibiotic prophylaxis in surgery. International Society of Surgery, Reinach, SwitzerlandGoogle Scholar
  9. Hill C, Flamant R, Mazas F, Evrand J (1985) Prophylactic cefazolin vs placebo in total hip replacement. Lancet 1:795–797Google Scholar
  10. Hirschmann JV (1987) Controversies in antimicrobial prophylaxis. Chemioterapia 6:202–207PubMedGoogle Scholar
  11. Kaiser AB (1986) Antimicrobial prophylaxis in surgery. N Engl J Med 315:1129–1138PubMedCrossRefGoogle Scholar
  12. Peters G (1987) Perioperative Antibiotikaprophylaxe in der Chirurgie. Dtsch Med Wochenschr 112:644–646PubMedCrossRefGoogle Scholar
  13. Postlethwait RW (1977) Infection. In: Sabiston DC (ed) Textbook of surgery. Saunders, PhiladelphiaGoogle Scholar
  14. Roth B, Müller J, Willenegger H (1985) Intraoperative Wundspülung mit einem neuartigen lokalen Antiseptikum. Helv Chir Acta 52:61–65PubMedGoogle Scholar
  15. Willenegger H, Roth B (1986) Behandlungstaktik und Spätergebnisse bei Frühinfarkt nach Osteosynthese. Unfallchirurgie 12:241–246PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • H. Willenegger

There are no affiliations available

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