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Interactions Between Macrophages and Legionella pneumophila

  • Chapter
Macrophage Biology and Activation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 181))

Abstract

Legionella pneumophila, the first member of the family Legionellaceae, is aerobic, motile, gram-negative bacterium that causes Legionnaires’ disease and Pontiac fever (Fraser et al. 1977; McDade et al. 1977; Glick et al. 1978). Although the family Legionellaceae now contains more than 40 species, L. pneumophila causes over 90% of human infections. L micdadei, the second most frequently isolated species in human infection, evidently has lower virulence for humans than L. pneumophila as it appears to infect only immunocompromised hosts (Myerowitz et al. 1971). L. pneumophila normally inhabits aquatic environments, and thus humans are accidental, albeit frequent hosts. The bacterium is spread to humans by the airborne route in aerosols arising out of contaminated sources; possibly, the organism is also spread to humans by the waterborne route (MUDER et al. 1986).

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  1. Division of Infectious Diseases, Department of Medicine, UCLA School of Medicine, Center for the Health Sciences, 37-121, Los Angeles, CA, 90024, USA

    M. A. Horwitz

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  1. University of Kansas Cancer Ctr., Kansas City, KA, 66160-7312, USA

    Stephen W. Russell (Wilkinson Distinguished Professor and Director) (Wilkinson Distinguished Professor and Director)

  2. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    Siamon Gordon

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Horwitz, M.A. (1992). Interactions Between Macrophages and Legionella pneumophila. In: Russell, S.W., Gordon, S. (eds) Macrophage Biology and Activation. Current Topics in Microbiology and Immunology, vol 181. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77377-8_10

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  • DOI: https://doi.org/10.1007/978-3-642-77377-8_10

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