Interactions Between Macrophages and Legionella pneumophila

  • M. A. Horwitz
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 181)


Legionella pneumophila, the first member of the family Legionellaceae, is aerobic, motile, gram-negative bacterium that causes Legionnaires’ disease and Pontiac fever (Fraser et al. 1977; McDade et al. 1977; Glick et al. 1978). Although the family Legionellaceae now contains more than 40 species, L. pneumophila causes over 90% of human infections. L micdadei, the second most frequently isolated species in human infection, evidently has lower virulence for humans than L. pneumophila as it appears to infect only immunocompromised hosts (Myerowitz et al. 1971). L. pneumophila normally inhabits aquatic environments, and thus humans are accidental, albeit frequent hosts. The bacterium is spread to humans by the airborne route in aerosols arising out of contaminated sources; possibly, the organism is also spread to humans by the waterborne route (MUDER et al. 1986).


Alveolar Macrophage Human Monocyte Complement Receptor Major Outer Membrane Protein Intracellular Multiplication 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • M. A. Horwitz
    • 1
  1. 1.Division of Infectious Diseases, Department of Medicine, UCLA School of MedicineCenter for the Health SciencesLos AngelesUSA

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