Pyrene-Labelled Lipids as Fluorescent Probes in Studies on Biomembranes and Membrane Models

  • Paavo K. J. Kinnunen
  • Anu Koiv
  • Pekka Mustonen

Abstract

The immense progress in the understanding of the functions of proteins and nucleic acids in living cells is still contrasted by the limited comprehension of the significance of lipids and their structural diversity in the self-assembly and functionalization of biological membranes. Nevertheless, taking into account the costly maintenance of the specific tissue, cell, and cell organelle lipid compositions and their alterations it is obvious that the individual lipid classes do serve more important roles than what is at present commonly accepted [1].

Keywords

Cholesterol Hydrocarbon Hexagonal Serine Tryptophan 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kinnunen PKJ (1991) Chem Phys Lipids 57: 375CrossRefGoogle Scholar
  2. 2.
    Lotta TI, Laakkonen LJ, Virtanen JA, Kinnunen PKJ (1988) Chem Phys Lipids 46: 1CrossRefGoogle Scholar
  3. 3.
    Lotta TI, Virtanen J, Kinnunen PKJ (1988) Chem Phys Lipids 46: 13CrossRefGoogle Scholar
  4. 4.
    Galla HJ, Hartmann W (1980) Chem Phys Lipids 27: 199CrossRefGoogle Scholar
  5. 5.
    Somerharju PJ, Virtanen JA, Eklund KK, Vainio P, Kinnunen PKJ (1985) Biochemistry 24: 2773CrossRefGoogle Scholar
  6. 6.
    Sunamoto J, Kondo H, Nomura T, Okamoto H (1980) J Am Chem Soc 102: 1146CrossRefGoogle Scholar
  7. 7.
    Chen S-Y, Cheng KH, Ortalano DM (1990) Chem Phys Lipids 53: 321CrossRefGoogle Scholar
  8. 8.
    Komatsu H, Rowe ES (1991) Biochemistry 30: 2463CrossRefGoogle Scholar
  9. 9.
    Thuren T, Vainio P, Virtanen JA, Somerharju P, Blomqvist K, Kinnunen PKJ (1984) Biochemistry 23: 5129CrossRefGoogle Scholar
  10. 10.
    Kinnunen PKJ, Thurén T, Vainio P, Virtanen JA (1985) In: Degiorgio V, Conti M (eds) Physics of Amphiphiles: Micelles, Vesicles and Microemulsions, Elsevier North-Holland, p 687Google Scholar
  11. 11.
    Eklund KK, Vuorinen J, Mikkola J, Virtanen JA, Kinnunen PKJ (1988) Biochemistry 27: 3433CrossRefGoogle Scholar
  12. 12.
    Jones ME, Lentz BR (1986) Biochemistry 25: 567CrossRefGoogle Scholar
  13. 13.
    Wiener JR, Pal R, Barenholz Y, Wagner RR (1985) Biochemistry 24: 7651CrossRefGoogle Scholar
  14. 14.
    Mustonen P, Virtanen J, Somerharju PJ, Kinnunen PKJ (1987) Biochemistry 26: 2991CrossRefGoogle Scholar
  15. 15.
    Hresko RC, Sugar IP, Barenholz Y, Thompson TE (1986) Biochemistry 25: 3813CrossRefGoogle Scholar
  16. 16.
    Hresko RC, Sugar IP, Barenholz Y, Thompson TE (1987) Biophys J 51: 725CrossRefGoogle Scholar
  17. 17.
    Kinnunen PKJ, Tulkki AP, Lemmetyinen H, Paakkola J, Virtanen JA (1987) Chem Phys Letters 136: 539CrossRefGoogle Scholar
  18. 18.
    Dudeja PK, Harig JM, Ramaswamy K, Brasitus TA (1989) J Am Physiol 257: G809Google Scholar
  19. 19.
    Homan R, Pownall HJ (1988) Biochim Biophys Acta 938: 155CrossRefGoogle Scholar
  20. 20.
    Thuren T, Virtanen JA, Kinnunen PKJ (1986) Chem Phys Lipids 41: 329CrossRefGoogle Scholar
  21. 21.
    Konttila R, Salonen I, Virtanen JA, Kinnunen PKJ (1988) Biochemistry 27: 7443CrossRefGoogle Scholar
  22. 22.
    Loughran T, Hatlee MD, Patterson LK, Kozak JJ (1980) J Chem Phys 72: 5791CrossRefGoogle Scholar
  23. 23.
    Subramanian R, Patterson LK (1985) J Am Chem Soc 107: 5821CrossRefGoogle Scholar
  24. 24.
    Caruso F, Grieser F, Murphy A, Thistlethwaite P, Urquhart R, Almgren M, Wistus E (1991) J Am Chem Soc 113: 4838CrossRefGoogle Scholar
  25. 25.
    Kinnunen PKJ, Virtanen JA, Tulkki AP, Ahuja RC, Möbius D (1985) Thin Solid Films 132:193CrossRefGoogle Scholar
  26. 26.
    Yamazaki T, Tamai N, Yamazaki I (1986) Chem Phys Letters 124: 326CrossRefGoogle Scholar
  27. 27.
    Yliperttula M, Lemmetyinen H, Mikkola J, Virtanen JA, Kinnunen PKJ (1988) Chem Phys Lett 152: 61CrossRefGoogle Scholar
  28. 28.
    Eklund KK (1990) Chem Phys Lipids 52: 149CrossRefGoogle Scholar
  29. 29.
    Doody MC, Pownall HJ, Kao YJ, Smith LC (1980) Biochemistry 19: 108CrossRefGoogle Scholar
  30. 30.
    Roseman MA, Thompson TE (1980) Biochemistry 19: 439CrossRefGoogle Scholar
  31. 31.
    Correa-Freire M, Barenholz Y, Thompson TE (1982) Biochemistry 21: 1244CrossRefGoogle Scholar
  32. 32.
    Massey JB, Gotto AM, Pownall HJ (1982) J Biol Chem 257: 5444Google Scholar
  33. 33.
    Massey JB, Hickson D, She HS, Sparrow JT, Via DP, Gotto AM, Pownall HJ (1984) Biochim Biophys Acta 794: 274Google Scholar
  34. 34.
    Via DP, Massey JB, Vignale S, Kundu SK, Marcus DM, Pownall HJ, Gotto AM (1985) Biochim Biophys Acta 837: 27Google Scholar
  35. 35.
    Massey JB, Hickson-Bick DP, Via AM, Gotto AM, Pownall HJ (1985) Biochim Biophys Acta 835: 124Google Scholar
  36. 36.
    van-Paridon PA, Gadella TW, Somerharju PJ, Wirtz KW (1988) Biochemistry 27: 6208CrossRefGoogle Scholar
  37. 37.
    Freire E, Markello T, Rigeli C, Holloway PW (1983) Biochemistry 22: 1675CrossRefGoogle Scholar
  38. 38.
    Jones OT, Lee AG (1985) Biochemistry 24: 2195CrossRefGoogle Scholar
  39. 39.
    Verbist J, Gadella TWJ, Raeymaekers L, Wuytack F, Wirtz KWA, Casteels R (1991) Biochim Biophys Acta 1063: 1CrossRefGoogle Scholar
  40. 40.
    Michelangeli F, Robson MJ, East JM, Lee AG (1990) Biochim Biophys Acta 1028: 49CrossRefGoogle Scholar
  41. 41.
    Mustonen P, Kinnunen PKJ (1991) J Biol Chem 266: 6302Google Scholar
  42. 42.
    Kaihovaara P, Raulo E, Kinnunen PKJ (1991) Biochemistry 30: 8380CrossRefGoogle Scholar
  43. 43.
    Thuren T, Virtanen JA, Kinnunen PKJ (1986) J Membr Biol 92: 1CrossRefGoogle Scholar
  44. 44.
    Thuren T, Virtanen JA, Somerharju PJ, Kinnunen PKJ (1988) Anal Biochem 170: 248CrossRefGoogle Scholar
  45. 45.
    Thuren & Kinnunen (1991) Chem Phys Lipids 59: 69CrossRefGoogle Scholar
  46. 46.
    Klar R, Levade T, Gatt S (1988) Clin Chim Acta 176: 259CrossRefGoogle Scholar
  47. 47.
    Salvayre R, Negre A, Radom J, Douste-Blazy L (1986) Clin Chem 32: 1532Google Scholar
  48. 48.
    Negre A, Salvayre R, Dousset N, Rogalle P, Dang QQ, Douste-Blazy L (1988) Biochim Biophys Acta 963: 340Google Scholar
  49. 49.
    Joutti A, Kotama L, Virtanen JA, Kinnunen PKJ (1985) Chem Phys Lipids 36: 335CrossRefGoogle Scholar
  50. 50.
    Levade T, Gatt S (1987) Biochim Biophys Acta 918: 250Google Scholar
  51. 51.
    Gatt S, Nahas N, Fibach E (1988) Biochem J 253: 377Google Scholar
  52. 52.
    Pownall HJ, Smith LC (1989) Chem Phys Lipids 50: 191CrossRefGoogle Scholar
  53. 53.
    Fibach E, Rachmilevitz EA, Gatt S (1989) Leuk Res 13: 1099CrossRefGoogle Scholar
  54. 54.
    Radom J, Salvayre R, Levade T, Douste-Blazy L (1990) Biochem J 269: 107Google Scholar
  55. 55.
    Naylor BL, Picardo M, Homan R, Pownall HJ (1991) Chem Phys Lipids 58: 111CrossRefGoogle Scholar
  56. 56.
    Viani P, Cervato G, Cestaro B (1991) Biochim Biophys Acta 1064: 24CrossRefGoogle Scholar
  57. 57.
    Förster Th, Kasper K (1955) Z Elektrochem 59: 976Google Scholar
  58. 58.
    Förster Th (1969) Angew Chem 81: 364CrossRefGoogle Scholar
  59. 59.
    Dong DC, Winnik MA (1984) Can J Chem 62: 2560CrossRefGoogle Scholar
  60. 60.
    Birks JB (1975) Rep Prog Phys 38: 903CrossRefGoogle Scholar
  61. 61.
    Lemmetyinen H, Yliperttula M, Mikkola J, Virtanen JA, Kinnunen PKJ (1989) J Phys Chem 93: 7170CrossRefGoogle Scholar
  62. 62.
    Barenholz Y, Cohen, Korenstein R, Ottolenghi M (1991) Biophys J 59: 110CrossRefGoogle Scholar
  63. 63.
    Sugar IP, Zeng J, Chong PL-G (1991) J Phys Chem 95: 7524CrossRefGoogle Scholar
  64. 64.
    O’Loughlin MA, Whillans DW, Hunt JW (1980) Radiation Res 84: 477CrossRefGoogle Scholar
  65. 65.
    Kinnunen PKJ, Laggner P (eds) (1991) Phospholipid phase transitions, Chem Phys Lipids 57Google Scholar
  66. 66.
    Goshima K, Masuda A, Owaribe K (1984) J Cell Biol 98: 801CrossRefGoogle Scholar
  67. 67.
    Mellström K, Heldin C-H, Westermark B (1988) Exp Cell Res 177: 347CrossRefGoogle Scholar
  68. 68.
    Needham D, Evans E (1988) Biochemistry 27: 8261CrossRefGoogle Scholar
  69. 69.
    Yechiel E, Edidin M (1987) J Cell Biol 105: 755CrossRefGoogle Scholar
  70. 70.
    Haverstick DM, Glaser M (1988) J Cell Biol 106: 1885CrossRefGoogle Scholar
  71. 71.
    Weiss RM (1991) Chem Phys Lipids 57: 227CrossRefGoogle Scholar
  72. 72.
    Virtanen JA, Somerharju P, Kinnunen PKJ (1988) J Mol Electronics 4: 233Google Scholar
  73. 73.
    Vainio P, Virtanen JA, Kinnunen PKJ, Voyta JC, Smith LC, Gotto AM, Sparrow JT, Pattus F, Verger R (1983) Biochemistry 22: 2270CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin HeidelBerg 1993

Authors and Affiliations

  • Paavo K. J. Kinnunen
    • 1
  • Anu Koiv
    • 1
  • Pekka Mustonen
    • 1
  1. 1.Lipid Research Laboratory, Department of Medical ChemistryUniversity of HelsinkiHelsinkiFinland

Personalised recommendations