Mechanisms of Regulation of Liver Regeneration

  • N. Fausto


It is well known that liver growth and size are precisely regulated both in human and animals [3, 17]. The best experimental system for the analysis of these regulatory mechanisms is the compensatory growth of the liver (liver regeneration) that occurs after partial hepatectomy in rats or mice. An almost exact human counterpart for this experimental system now exists, as shown by studies of the regulation of the size and growth of transplanted human livers [32]. It appears that both in human and animals liver functional deficiencies relative to body demands can trigger cell proliferation in the normally quiescent adult liver. However, other studies have indicated that hepatic growth is at least in part regulated by the liver itself through circuits and mediators operating within the hepatic tissue. Thus, it is likely that functional demands in the liver or perhaps the metabolic adaptations set in motion in the liver in response to these demands activate hepatic growth regulatory circuits that lead to hepatocyte proliferation.


Hepatocyte Growth Factor Transform Growth Factor Liver Regeneration Partial Hepatectomy Liver Growth 
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© Springer-Verlag Berlin Heidelberg 1992

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  • N. Fausto

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