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Aminoacyl-tRNA Synthetases: Partition into two Classes

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Nucleic Acids and Molecular Biology

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 6))

Abstract

Aminoacyl-tRNA synthetases (aaRS) constitute a family of enzymes that catalyze the specific attachment of one amino acid (aa) to its cognate tRNA in what is a key step in the translation of the genetic information during protein biosynthesis. This enzymatic reaction requires ATP and can be decomposed in two steps:

$$\begin{gathered} \operatorname{aa} + ATP \to aa - AMP + PPi \hfill \\ \operatorname{aa} - AMP + tRNA \to aa - tRNA + AMP \hfill \\ \end{gathered} $$

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Authors and Affiliations

  1. Laboratoire de Cristallographie Biologique, I.B.M.C. du C.N.R.S., 15 Rue R. Descartes, 67000, Strasbourg, France

    D. Moras

Authors
  1. M. Delarue
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  2. D. Moras
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Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, W-3400, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, DD1 4HN, Dundee, UK

    David M. J. Lilley

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Delarue, M., Moras, D. (1992). Aminoacyl-tRNA Synthetases: Partition into two Classes. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77356-3_12

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  • DOI: https://doi.org/10.1007/978-3-642-77356-3_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77358-7

  • Online ISBN: 978-3-642-77356-3

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