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Genetic Studies of Pre-mRNA Splicing in Yeast

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Nucleic Acids and Molecular Biology

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 6))

Abstract

Nuclear pre-mRNA splicing involves the removal from primary transcripts of internal, usually noncoding, intron sequences and joining of the protein-coding exons to produce mature mRNA. Although the majority of eukaryotic nuclear protein-encoding genes contain introns, in the yeast Saccharomyces cerevisiae there are relatively few intron-containing genes, and most of these have only a single intron near the 5′ end. Most introns in this fast-growing, simple eukaryote have no apparent function, and many have probably been eliminated by selective pressures (Fink 1987). However, as many of the intron-containing genes in yeast encode essential functions, pre-mRNA splicing is necessary for cell viability.

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Author information

Authors and Affiliations

  1. Institute of Cell and Molecular Biology, University of Edinburgh, King’s Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK

    M. Plumpton

Authors
  1. J. D. Beggs
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  2. M. Plumpton
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Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, W-3400, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, DD1 4HN, Dundee, UK

    David M. J. Lilley

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© 1992 Springer-Verlag Berlin Heidelberg

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Beggs, J.D., Plumpton, M. (1992). Genetic Studies of Pre-mRNA Splicing in Yeast. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77356-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-77356-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77358-7

  • Online ISBN: 978-3-642-77356-3

  • eBook Packages: Springer Book Archive

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