Base-Pair Opening in Double-Stranded Nucleic Acids

  • M. Guéron
  • J.-L. Leroy
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 6)

Abstract

In the equilibrium configuration, double-stranded nucleic acids are held together by hydrogen-bonded base pairs, often according to the Watson-Crick pairing scheme. Spontaneous fluctuations of these structures are of different types and time scales, and they have attracted much attention. One reason is simply that a structure is not fully understood if its fluctuations are not characterized. Another reason is that the biochemical functions of nucleic acids involve distortions such as bending, twisting, base-pair opening and strand separation, whose understanding benefits from the study of the related spontaneous fluctuations.

Keywords

Adenosine Oligomer Adenine Deuterium Pyrimidine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • M. Guéron
  • J.-L. Leroy
    • 1
  1. 1.Groupe de BiophysiqueEcole PolytechniquePalaiseauFrance

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