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ACE-Hemmer-Therapie und Natrium-Volumen-Regulation

  • Conference paper
Bedeutung von Natrium und Chlorid für den Menschen

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Zusammenfassung

Dem Renin-Angiotensin-Aldosteron-System kommt bei der Regulation der Natrium-Volumen-Homöostase eine wesentliche Bedeutung zu [12, 13, 16, 23], so daß durch hemmende Einflüsse auf dieses System wesentliche Konsequenzen für die Blutdruckregulation und die Nierenfunktion entstehen [1, 2, 3, 4, 9, 18]. Angiotensin II ist ein wirksamer Konstriktor der glatten Gefäßmuskulatur und stimuliert die Aldosteron-Biosynthese in der Zona glomerulosa der Nebennieren [5, 6, 8]. Darüber hinaus lassen sich Beeinflussungen des Nebennierenmarkes, des sympathischen Nervensystems, der Natriumausscheidung durch die Niere und zentralnervöse Wirkungen auf Blutdruckkontrolle, Durst und Salz-Appetit und die Freisetzung von hypophysären Hormonen nachweisen [7, 11, 24]. Viele dieser Wirkungen stehen in Beziehung zur Blutdruckregulation, sowohl über direkte Gefäßeffekte als auch über die Beeinflussung der Natrium- und Volumen-Homöostase des Organismus (Tabelle 1) [14, 15].

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Authors and Affiliations

  1. Bonn, Deutschland

    R. E. Kolloch

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  1. R. E. Kolloch
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Editors and Affiliations

  1. Abteilung Ernährungsphysiologie, Universität Hohenheim (Stuttgart), Deutschland

    Hans-Jürgen Holtmeier (Prof. und Leiter) (Prof. und Leiter)

  2. Medizin der Universität, Freiburg i. Br., Deutschland

    Hans-Jürgen Holtmeier (Prof. und Leiter) (Prof. und Leiter)

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© 1992 Springer-Verlag Berlin Heidelberg

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Kolloch, R.E. (1992). ACE-Hemmer-Therapie und Natrium-Volumen-Regulation. In: Holtmeier, HJ. (eds) Bedeutung von Natrium und Chlorid für den Menschen. Schriftenreihe der Gesellschaft für Mineralstoffe und Spurenelemente e.V.. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77340-2_12

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  • DOI: https://doi.org/10.1007/978-3-642-77340-2_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77341-9

  • Online ISBN: 978-3-642-77340-2

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