Intragenic Recombination within the Alpha-1-Antitrypsin Locus
The alpha-1-antitrypsin (Pi) system displays more than 60 alleles. The Mallele is the most frequent with a frequency of 0.9463 in a Swedish population (Hjalmarsson 1988). More unusual alleles are the S, Z and F alleles. Furthermore, the M allele can be split into the suballeles Ml, M2 , M3 and M4 . The amino acid sequences have been determined by DNA sequencing and the following genetic model for the Pi M suballeles has been suggested (Long 1984; Nukiwa 1988; Crystal 1989; Graham 1990).
KeywordsIntragenic Recombination Paternity Case False Exclusion Unusual Allele Strand Stage
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