Abstract
Continuous distributions of fragments are still characteristic of the highly polymorphic single locus VNTR systems (Puers et al. 1991). To solve these problems different bin approaches and match criteria have been elaborated (Baird et al. 1986, Brenner and Morris 1990, Gill et al. 1990). Another inherent problem lies in the use of λ-DNA as marker DNA whose sequences differ considerably from those to be measured. The electrophoretic mobility of DNA is also influenced by sequence and composition. Therefore, λ-DNA is basically not suitable for estimating size of (human) fragments. One concept for a more exact estimation of allele size is to compare the unknown human fragment with a human DNA standard composed of as many alleles from the system under investigation as possible (Puers et al. 1991).
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© 1992 Springer-Verlag Berlin Heidelberg
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Puers, C., Wiegand, P., Brinkmann, B. (1992). Investigations to Improve Allele Definition in the “Collagen 2A1” System (AMP-FLP). In: Rittner, C., Schneider, P.M. (eds) Advances in Forensic Haemogenetics. Advances in Forensic Haemogenetics, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77324-2_6
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DOI: https://doi.org/10.1007/978-3-642-77324-2_6
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