Abstract
The region s1tuatea downstream or the apolipoprotein B exon contains a hypervariable sequence (APO B HVR, APO B) organized in tandem repeat units. Its polymorphism was described by Boherwinkle et al (1989) using the polymerase chain reaction technique (PCR). These authors reported the existence of 12 allelomorphic fragments in Caucasians with a heterozygosity index amounting to 0.75. Since then, APOB has become a widespread marker, frequently used in forensics. In view of the application of this polymorphism to our routine casework, we have undertaken a population survey on the distribution of its alleles in the population of Central and Southern Italy. Here we report data referring to a first share of typed samples (109 unrelated individuals) from our reference population.
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References
Boerwinkle E, Xijong W, Fourest E, Chan L (1989) Rapid typing of tandemly repeated hypervariable loci by the Polymerse chain reaction: Application to the apolipoprotein B 3′hypervariable region. Proc Natl Acad Sci USA 86: 212–216
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© 1992 Springer-Verlag Berlin Heidelberg
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d’Aloja, E., Dobosz, M., Pescarmona, M., Moscetti, A., Pascali, V.L. (1992). Gene frequencies of APOB alleles in a sample of random Italian individuals (Central and Southern Italy). In: Rittner, C., Schneider, P.M. (eds) Advances in Forensic Haemogenetics. Advances in Forensic Haemogenetics, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77324-2_17
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DOI: https://doi.org/10.1007/978-3-642-77324-2_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-55194-2
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