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Grading of Soft Tissue Sarcomas: Proposal for a Reproducible, Albeit Limited Scheme

  • Chapter
Soft Tissue Tumors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 89))

Abstract

After determination of the histological type a grading has to be carried out according to accepted criteria including cellularity, pleomorphism, mitotic activity and necrosis. The presence of intercellular substances, collagenous or mucoid, ought to be considered as favorable factor judging the degree of differentiation.

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References

  • Altmannsberger M, Alles J, Fitz H, Jundt G, Osborn M (1986) Mesenchymale Tumormarker. Verh Dtsch Ges Pathol 72: 150–163

    Google Scholar 

  • Appelman H (1986) Smooth muscle tumors of the gastrointestinal tract. Am J Surg Pathol 10 (Suppl 1): 83–99

    PubMed  Google Scholar 

  • Baak J (1990) Mitosis counting in tumors. Hum Pathol 21: 683–684

    Article  PubMed  CAS  Google Scholar 

  • Baak J, Oort J (1983) A manual of morphometry in diagnostic pathology. Springer, Berlin Heidelberg New York

    Book  Google Scholar 

  • Bauer H, Kreisberg A, Tribukait B (1991) DNA content prognosis in soft tissue sarcoma. Acta Orthop Scand 62: 187–194

    Article  PubMed  CAS  Google Scholar 

  • Becker R, Venzon D, Lack E et al. (1991) Cytometry and morphometry of malignant fibrous histiocytoma of the extremities. Am J Surg Pathol 15: 957–964

    Article  PubMed  Google Scholar 

  • Böcking A (1990) DNA-Zytometrie und Automation in der klinischen Diagnostik. Verh Dtsch Ges Pathol 74: 176–185

    PubMed  Google Scholar 

  • Böcking A, Adler C, Common H et al. (1984) Algorithm for a DNA cytophotometric diagnosis and grading of malignancy. Anal Quant Cytol 30: 1–8

    Google Scholar 

  • Broders A, Hargrave R, Meyerding H (1939) Pathological features of soft tissue fibrosarcoma: with special reference to the grading of its malignancy. Surg Gyneco Obstet 69: 267–280

    Google Scholar 

  • Brooks J (1982) Immunohistochemistry of soft tissue tumors. Hum Pathol 13: 969–974

    Article  PubMed  CAS  Google Scholar 

  • Brooks J (1986) The significance of double phenotypic pattern and markers in human saracomas. Am J Pathol 125: 113–123

    PubMed  CAS  Google Scholar 

  • Brooks J (1989) Disorders of soft tissue. In: Sternberg S (ed) Diagnostic surgical pathology. Raven, New York

    Google Scholar 

  • Brown D, Theaker J, Banks P, Gatter K, Mason D (1987) Cytokeratin expression in smooth muscle tumors. Histopathology 11: 477–486

    Article  PubMed  CAS  Google Scholar 

  • Castro E, Hajdu S, Fortner J (1973) Surgical therapy of fibrosarcoma of extremities: a reappraisal. Arch Surg 107: 284–286

    Article  PubMed  CAS  Google Scholar 

  • Coindre J, de Marscarel A, Trojani M, de Mascarel I, Pages A (1988a) Immunohistohemical study of rhabdomyosarcoma. Unexpected staining with S 100 protein and cytokeratin. J Pathol 155: 127–132

    Article  PubMed  CAS  Google Scholar 

  • Coindre J, Bui N, Bonichon F et al. (1988b) Histopathologic grading in spindle cell soft tissue sarcomas. Cancer 61: 2305–2309

    Article  PubMed  CAS  Google Scholar 

  • Costa J, Wesley R, Glatstein E, Rosenberg S (1984) The grading of soft tissue sarcomas. Cancer 53: 530–541

    Article  PubMed  CAS  Google Scholar 

  • Cross S, Start R, Smith J (1990) Does delay in fixation affect the number of mitotic figures in processed tissue? J Clin Pathol 43: 597–599

    Article  PubMed  CAS  Google Scholar 

  • Dallenbach F (1979) Das sogenannte Leiomyosarkom in situ des Uterus. Verh Dtsch Ges Pathol 63: 633–640

    Google Scholar 

  • Donhuijsen K (1986) Reproducibility and significance in grading of malignancy. Hum Pathol 17: 1122–1125

    Article  PubMed  CAS  Google Scholar 

  • Donhuijsen K, Budach V, van Beuningen D, Schmidt U (1988) Instability of xenotransplanted soft tissue sarcomas. Cancer 61: 68–75

    Article  PubMed  CAS  Google Scholar 

  • Donhuijsen K, Schmidt U, Hirche H et al. (1990) Changes in mitotic rate and cell cycle fractions caused by delayed fixation. Hum Pathol 21: 709–714

    Article  PubMed  CAS  Google Scholar 

  • Eilber F, Huth J, Mirra J, Rosen G (1990) Progress in the recognition and treatment of soft tissue sarcomas. Cancer 65: 660–666

    Article  PubMed  CAS  Google Scholar 

  • El-Naggar, Garcia G (1992) Epitheloid sarcoma. Flow cytometric study of DNA content and regional DNA heterogeneity. Cancer 69: 1721–1728

    Article  PubMed  CAS  Google Scholar 

  • Enzinger F, Weiss S (1988) Soft tissue tumors, 2nd edn. Mosby, St Louis

    Google Scholar 

  • Enzinger F, Winslow D (1962) Liposarcoma: a study of 103 cases. Virchows Arch 335: 361–388

    Google Scholar 

  • Erlandson R (1984) Diagnostic immunohistochemistry of human tumors. An interim evaluation. Am J Surg Pathol 8: 615–624

    Article  PubMed  CAS  Google Scholar 

  • Eto H, Toiyam K, Tsuda N, Tagawa Y, Itakura H (1992) Flow cytometric DNA analysis of vascular soft tissue tumors, including African endemic-type Kaposi’s sarcoma. Hum Pathol 23: 1055–1060

    Article  PubMed  CAS  Google Scholar 

  • Evans H (1979) Liposaracoma: a study of 55 cases with reassessment of its classification. Am J Surg Pathol 3: 507–523

    Article  PubMed  CAS  Google Scholar 

  • Evans H, Soule E, Winkelman R (1979) Atypical lipoma, atypical intramuscular lipoma, and well differentiated retroperitoneal liposarcoma. Cancer 43: 574–584

    Article  PubMed  CAS  Google Scholar 

  • Fidler I (1978) Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 38: 2651–2660

    PubMed  CAS  Google Scholar 

  • Garcia R, Coltrera M, Gown A (1989) Analysis of proliferative grade using anti-PCNA/cyclin monclonal antibodies in fixed, embedded tissues: comparison with flow cytometry analysis. Am J Pathol 134: 733–739

    PubMed  CAS  Google Scholar 

  • Gerdes J, Becker M, Key G, Cattoretti (1992) Immunhistological detection of tumor growth factor (Ki-67 antigen) in formalinfixed and routinely processed tissue. J Pathol (in press)

    Google Scholar 

  • Graem N, Helweg-Larsen K (1979) Mitotic activity and delayed fixation of tumor tissue. Acta Pathol Scand [A] 87: 375–378

    Google Scholar 

  • Haapsalo H, Pesonen E (1989) Volume corrected mitotic index ( M/V-Index ). Pathol Res Pract 185: 551–554

    Google Scholar 

  • Hajdu S (1979) Pathology of soft tissue tumors. Lea and Febiger, Philadelphia

    Google Scholar 

  • Hall P, Levison D, Woods A et al. (1990) Proliferating nuclear antigen (PCNA) immunolocalisation in paraffin sections. J Pathol (in press)

    Google Scholar 

  • Haukins H, Camacko-Velasquez J (1987) Rhabdomyosarcoma in children. Am J Surg Pathol 11: 531–542

    Article  Google Scholar 

  • Hedley O, Friedlander M, Taylor I et al (1983) Methods for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 31: 1333

    Article  PubMed  CAS  Google Scholar 

  • Hedley O, Friedlander M, Taylor I (1985) Application of DNA flow cytometry of paraffin- embedded archival material for the study of aneuploidy and its clinical significance. Cytometry 6: 327–333

    Article  PubMed  CAS  Google Scholar 

  • Hermanek P, Scheibe O, Spiessl B, Wagner G (1987) TNM-Klassifikation maligner Tumoren, 4th edn. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Hilsenbeck S, Allred D (1992) Improved method of estimating mitotic activity in solid tumors. Hum Pathol 23: 601–602

    Article  PubMed  CAS  Google Scholar 

  • Iwasaki H, Isayama T, Johzaki K, Kikuchi M (1987) MFH: evidence of perivascular mesenchymal cell origin. Am J Pathol 128: 528–537

    PubMed  CAS  Google Scholar 

  • Katenkamp D (1988) Cellular heterogeneity. Explanation of changing of tumor phenotype and biologic behaviour in soft tissue sarcomas. Pathol Res Pract 183: 698–705

    Article  PubMed  CAS  Google Scholar 

  • Katenkamp D, Raikhlin (1985) Stem cell concept and heterogeneity of malignant soft tissue tumors. Exp Pathol 28: 3–11

    Article  PubMed  CAS  Google Scholar 

  • Katenkamp D, Stiller D (1990) Weichgewebstumoren. Barth, Jena

    Google Scholar 

  • Key G, Becker M, Baron B et al. (1992) Preparation and immunobiochemical haracterization of Ki-67 equivalent murine antibody (MIB 1-3) generated against recombinant parts of the Ki-67 antigen (to be published)

    Google Scholar 

  • Killion J, Fidler I (1989) The biology of tumor metastasis. Sem Oncol 16: 106–115

    CAS  Google Scholar 

  • Kiyabu M, Bishop B, Parker J et al. (1988) Smooth muscle tumors of the gastrointestinal tract. Flow cytometric quantitation of DNA and nuclear antigen content and correlation with histologic grade. Am J Surg Pathol 12: 954–960

    Article  PubMed  CAS  Google Scholar 

  • Kreicberg A, Söderberg A, Zetterberg A (1980) The prognostic significance of nuclear DNA-content in chondrosarcoma. Anal Quant Cytol 4: 271

    Google Scholar 

  • Kreicberg A, Tribukeit B, Willem J et al. (1987) DNA flow analysis in soft tissue tumors. Cancer 59: 128–133

    Article  Google Scholar 

  • Landberg G, Tan E, Roos G (1990) Flow cytometric multiparameter analysis of cell nuclear antigen/eyclin and Ki-67 antigen. Exp Cell Res 187: 111–118

    Article  PubMed  CAS  Google Scholar 

  • Mackenzie D (1964) Fibroma: a dangerous diagnosis. Br J Surg 51: 607–612

    Article  PubMed  CAS  Google Scholar 

  • Meister P (1988) Weichgewebssarkome. Klassifizierung oder Graduierung? Zentralbl Allg Pathol Pathol Anat 134: 355–362

    CAS  Google Scholar 

  • Meister P (1992) Weichgewebssarkome. I. Allgemeines. Fortbld Aktuel Krebsdiagn Ther 60 /61: 29–34

    Google Scholar 

  • Miettinen M, Lehto V, Badley R, Virtanen I (1982) Expression of intermediate filaments in soft-tissue sarcomas. Int J Cancer 30: 541–546

    Article  PubMed  CAS  Google Scholar 

  • Myhre-Jensen O, Kaae O, Madsen E et al. (1983) Histopathological grading in soft tissue tumors. Acta Pathol Scand [A] 91: 145–150

    CAS  Google Scholar 

  • Perrone T, Dehner L (1988) Prognostically favorable “mitotically active” smooth-muscle tumors of the uterus. Am J Surg Pathol 12: 1–8

    Article  PubMed  CAS  Google Scholar 

  • Pritchard D, Soule E, Taylor W, Ivins J (1974) Fibrosaroma. Cancer 33: 888–897

    Article  PubMed  CAS  Google Scholar 

  • Quinn C, Wright N (1990) The clinical assessment of proliferation and growth in human tumors. J Pathol 160: 93–102

    Article  PubMed  CAS  Google Scholar 

  • Rabes H, Meister P (1979) Analysis of proliferative compartments in human tumors. Cancer 44: 799–813

    Article  PubMed  CAS  Google Scholar 

  • Rüssel W, Cohen J, Enzinger F et al. (1977) A clinical pathological staging system for soft tissue sarcomas. Cancer 40: 1562–1570

    Article  Google Scholar 

  • Sadler D, Coghill S (1989) Histopathologists, malignancies and undefined high-power fields. Lancet 333: 785–786

    Article  Google Scholar 

  • Sapi Z, Bodo M, Sugar J (1989) DNA cytometry of soft tissue tumors with TV image analysis. Pathol Res Pract 185: 363–367

    Article  PubMed  CAS  Google Scholar 

  • Schmidt D, Reimann O, Treuer J, Harms D (1986) Cellular differentiation and prognosis in embryonal rhabdomyosarcoma. Virchows Arch 409: 183–194

    Article  CAS  Google Scholar 

  • Schutte B, Reynder M, Bosman F et al. (1985) Flow cytometric determination of DNA ploidy level in nuclei isolated from paraffin-embedded material. Cytometry 6: 26–30

    Article  PubMed  CAS  Google Scholar 

  • Scott S, Reiman H, Pritchard D, Ilstrup DC (1989) Soft tissue fibrosarcoma. Cancer 64: 925–931

    Article  PubMed  CAS  Google Scholar 

  • Silverberg S (1976) Reproducibility of the mitotic count in the histologic diagnosis of smooth muscle tumors of the uterus. Hum Pathol 7: 451–454

    Article  PubMed  CAS  Google Scholar 

  • Silvestrini R, Costa A, Veneroni S et al. (1988) Camparative analysis of different approaches to investigate cell kinetics. Cell Tissue Kinet 21: 123–131

    PubMed  CAS  Google Scholar 

  • Simpson J, Dutt P, Page D (1992) Expressions of mitoses per thousend cells and cell density in breast carcinoma. Hum Pathol 23: 608–611

    Article  PubMed  CAS  Google Scholar 

  • Stenfert Kroese M, Rutgeres D, Wils I et al. (1990) The relevance of the DNA index and proliferation rate in the grading of benign and malignant soft tissue tumors. Cancer 65: 1782–1788

    Article  Google Scholar 

  • Sulser H (1978) Das Rhabdomysarkom. Virchows Arch 379: 35–71

    CAS  Google Scholar 

  • Swanson S, Brook G (1990) Proliferation markers Ki-67 and pl04 in soft tissue lesions. Am J Pathol 137: 1491–1500

    PubMed  CAS  Google Scholar 

  • Takafumi U, Katsuyuki A, Masahiko T (1989) Prognostic significance of Ki-67 reactivity in soft tissue sarcomas. Cancer 63: 1607

    Article  Google Scholar 

  • Tham K (1992) Estimation of mitotic count in tumors. Hum Pathol 23: 1313–1314

    Article  PubMed  CAS  Google Scholar 

  • Van Haelst-Pisani C, Buckner J, Reiman H, Schaid D, Edmonson J, Hahn R (1991) Does histologic grade in soft tissue sarcoma influence response rate to systemic chemotherapy? Cancer 68: 2354–2358

    Article  PubMed  Google Scholar 

  • Van Unnik J, Coinder J, Contesso G et al. (1987) Grading of soft tissue sarcomas. In: Ryan JR, Baker LO (eds) Recent concepts in sarcoma treatment. Kluwer, Utrecht

    Google Scholar 

  • Waaseem N, Lane D (1990) Monoclonal antibody analysis of the proliferating cell nuclear antigen ( PCNA ). J Cell Sci 90: 121–129

    Google Scholar 

  • Weiss S (1993) Histological typing of soft tissue tumors, 2nd edn. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Weiss S, Bratthauer G, Morris P (1988) Postirradiation malignant fibrous histiocytoma expres-sing cytokeratin. Am J Surg Pathol 12: 554–558

    Article  PubMed  CAS  Google Scholar 

  • Zehrer R, Bauer T, Marks K, Weltevreden A (1990) Ki-67 and grading of malignant fibrous histiocytoma. Cancer 66: 1984–1990

    Article  Google Scholar 

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Authors
  1. P. Meister
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Editors and Affiliations

  1. Institut für Paidopathologie, Klinikum der Christian-Albrechts-Universität, Michaelisstr. 11, 24105, Kiel, Germany

    D. Harms Professor Dr.

  2. Institut für Pathologie, A2,2, 68159, Mannheim, Germany

    D. Schmidt Professor Dr.

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© 1995 Springer-Verlag Berlin Heidelberg

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Meister, P. (1995). Grading of Soft Tissue Sarcomas: Proposal for a Reproducible, Albeit Limited Scheme. In: Harms, D., Schmidt, D. (eds) Soft Tissue Tumors. Current Topics in Pathology, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77289-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-77289-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77291-7

  • Online ISBN: 978-3-642-77289-4

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