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QSAR Studies in Genetic Toxicology: Congeneric and Non Congeneric Chemicals

  • Romualdo Benigni
  • Alessandro Giuliani
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 15)

Abstract

The Quantitative Structure-Activity Relationship (QSAR) methods are an important tool for the study of biological action mechanisms and for the prediction of chemical activity. The QSAR studies, although originally developed at the end of last century, were spurred on in the Sixties by the contributions of Corwin Hansen, as well as other investigators. It has been found that, for congeneric chemicals, it is possible to quantitatively correlate biological activity with physical chemical properties, such as hydrophobicity, steric and electronic factors (Hansch, 1990). Congeneric chemicals are those agents that share a common skeleton, but have different substituents attached to it. This approach –called extrathermodynamic or the Hansch approach- has been subsequently applied to a large number of situations, and has been highly refined. A great advantage of this method is that the physical chemical properties of most chemicals can be theoretically estimated.

Keywords

Physical Chemical Property Nitroaromatic Compound QSAR Study Topological Approach National Toxicology Program 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Romualdo Benigni
    • 1
  • Alessandro Giuliani
    • 1
  1. 1.Istituto Superiore di Sanita’Laboratory of Comparative Toxicology and EcotoxicologyRomeItaly

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