Research Aspects in Clinical Toxicology

  • Dag Jacobsen
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 15)

Abstract

Clinical toxicology is an old discipline with a young an still immature academic impact. Over the last two decades, however, much research information has been available with better and better scientific quality. Though most of the documentation is still based on case reports, their quality has improved and some multicenter studies have also been performed in which different treatment procedures have been evaluated.

Keywords

Placebo Toxicity Glycol Expense Bismuth 

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References

  1. Aarseth HP, Bredesen JE, Grynne B, Lyngdal PT, Storstein L, Wiik Larsen E. Benzodiazepine antagonist, a clinical double blind study. J Toxicol Clin Toxicol 1988, 26, 283–92.PubMedGoogle Scholar
  2. Bismuth C, Baud F, Fournier E, Mellerio F. RO 15–1788 dans l’intoxication volontaire par les benzodiazepines. Valeur diagnostique et therapeutique. Annales de Medecine Interne 1986, 137, 363–4.Google Scholar
  3. Clausen TG, Wolff J, Carl P, Theilgaard A. The effect of the benzodiazepine antagonist, flumazenil, on psychometric performance in acute ethanol intoxication in man. Eur J Clin Pharmacol 1990, 38, 233–6.PubMedCrossRefGoogle Scholar
  4. Ding GS, Liang YY. Antidotal effects of dimercaptosuccinic acid. J Appl Toxicol 1991, 11,7–14.PubMedCrossRefGoogle Scholar
  5. Ding GS, Liang YY, Shi J, Chen W, Gu Z, Jin J. Antidotal effects of sodium dimercaptosuccinate on the intoxications from many metals (in Chinese). Chinese Medical Journal 1965, 57, 304–7.Google Scholar
  6. Ekeberg Ø, Ellingsen Ø, Jacobsen D. Suicide and other causes of death in a five-year follow-up of patients treated for self-poisoning in Oslo. Acta Pshychiatr. Scand 1991, 83, 432–7.CrossRefGoogle Scholar
  7. Jacobsen D et al. A prospective study of 1212 cases of acute poisonings. General epidemiology. Hum Toxicol 1984, 3, 93–106.PubMedCrossRefGoogle Scholar
  8. Jacobsen D, McMartin KE. Methanol and ethylene glycol poisonings. Med Toxicol 1986, 1, 309–34.PubMedGoogle Scholar
  9. Jacobsen D, Sebastian CS, Blomstrand R, McMartin KE. 4-methylpyrazole: Safety in human volunteers after single ascending doses. Alcoholism Clin Exp Res 1988, 12, 516–22.CrossRefGoogle Scholar
  10. Jacobsen D, Barron SK, Sebastian CS, Blomstrand R, McMartin KE. Nonlinear kinetics of 4-methylpyrazole in healthy human subjects. Eur J Clin Pharmacol 1989, 37, 599–604.PubMedGoogle Scholar
  11. Jacobsen D, Barron SK, Sebastian CS, McMartin KE. Effects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans. J Emerg Med 1990, 8, 455–61.PubMedCrossRefGoogle Scholar
  12. Kreyberg S, Torvik A, Bjomeboe A, Wiik Larsen E, Jacobsen D.Trimethyltin poisoning. Report of a case with postmortem examination. Clin Neuropathol, in press.Google Scholar
  13. Nuotto E, Palva ES, Seppala T. Naloxone-ethanol interaction in experimental and clinical situations. Acta Pharmacol Toxicol 1984, 54, 278–84.CrossRefGoogle Scholar
  14. Ritz R, Zuber M, Elsasser S, Scollo-Lavizzari G. Use of flumazenil in intoxicated patients with coma. A double-blind placebo-controlled study in ICU. Intensive Care Med 1990, 16, 242–7.PubMedCrossRefGoogle Scholar
  15. Tephly TR, McMartin KE. Methanol metabolism and toxicity. In Stegink & Filer (eds) Aspartame: physiology and biochemistry, pp. 111–140, Marcel Dekker, New York, 1984.Google Scholar
  16. Rygnestad T. A prospective 5-years follow-up study of self-poisoned patients. Acta Psychiatr Scand 1988, 77, 328–31.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Dag Jacobsen
    • 1
  1. 1.Section of Acute Medicine & Cardiology Department of MedicineUllevål University HospitalNorway

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