Abstract
The many different cell types identified in the lungs show a broad variation in morphology, function and metabolic capacity. Because of this variation certain cell types are more susceptible to the toxic insult of chemical exposures. The bronchiolar Clara cells and the alveolar type II cells are known to express relatively high levels of the P450 system compared to other pulmonary cell types (Boyd 1977; Philpot and Smith 1984; Minchin 1983). These cell types also appear to be target cells for several chemicals activated by P450 dependent reactions (Boyd and Reznik-SchüTler 1984). Furthermore, Clara and type II cells are able to proliferate. Of particular interest for activation of a number of known lung carcinogens seems to be the expression of the P450 IIB1 gene in Clara and type II cells making them possible primary target cells for initiation of lung carcinogenesis (Belinsky et al. 1989; Becher et al. 1991).
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© 1992 Springer-Verlag Berlin Heidelberg
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Becher, R. et al. (1992). Selective Cellular Toxicity After Exposure to 4-Ipomeanol, Bromobenzene (BrBz) and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) in Rat Lungs. In: Bolt, H.M., de Wolff, F.A., Henderson, P.T. (eds) Medical Toxicology. Archives of Toxicology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77260-3_19
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DOI: https://doi.org/10.1007/978-3-642-77260-3_19
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