Animal Studies for Prediction of Chronic Toxicity
The aim of a chronic toxicity study is to administer the test substance for a long enough period for chronic effects to be realised. It may be equally important to determine the progression of effects seen in shorter term toxicity studies. The number of animals and dose levels should be sufficient to establish dose response characteristics and a no effect level. The range of examinations within the study should cover several parameters of toxicity and, where possible, examinations should be undertaken at intervals throughout the study to follow the development of any chronic effects.
KeywordsMaximum Tolerate Dose Test Substance Chronic Toxicity Inhalation Study Chronic Study
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