Abstract
The aim of a chronic toxicity study is to administer the test substance for a long enough period for chronic effects to be realised. It may be equally important to determine the progression of effects seen in shorter term toxicity studies. The number of animals and dose levels should be sufficient to establish dose response characteristics and a no effect level. The range of examinations within the study should cover several parameters of toxicity and, where possible, examinations should be undertaken at intervals throughout the study to follow the development of any chronic effects.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Farber T.M. (1987) Selection of a Maximum Tolerated Dose (MTD) in Oncogenicity Studies: A position document of the US Environmental Protection Agency Office of Pesticide Programs EPA 540/09–88–003, Washington DC.
Gifap (1982) Position paper: Chronic Toxicity in the Dog, GIFAP bulletin 8(4).
de Groot A.P. Feron V.J. and Immel H.R. (1988) Induction of Hyperplasia in the Bladder Epithelium of Rats by a Dietary Excess of Acid or Base: Implications for Toxicity/Carcinogenicity Testing. Fd. Chem. Tox. 26 425–434.
Hart R.W. and Chou M.W. (1991) Calorie Restrictions and Chemical Toxicity/Carcinogenesis, Proceedings of the First International Conference on Food, Nutrition and Chemical Toxicity, Surrey, UK (in press).
Haseman J.K. (1985) Issues in Carcinogenicity Testing: Dose selection. Fund. Appl. Toxicol 5 66–78.
Lumley C.E. and Walker S.R. (1986) A Critical Appraisal of the Duration of Chronic Animal Toxicity Studies. Reg. Tox. and Pharmacol 6 66–72.
Paynter O.E., Harris J.E., Burin G.J. and Jaeger R.B. (1985) Hazard Evaluation Division Standard Evaluation Procedure. Toxicity Potential: Guideline for Analysis and Evaluation of Sub-chronic and ChronicExposure Studies. EPA-540/9 85–020, United States Environmental Protection Agency, Washington DC.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Pigott, G.H. (1992). Animal Studies for Prediction of Chronic Toxicity. In: Bolt, H.M., de Wolff, F.A., Henderson, P.T. (eds) Medical Toxicology. Archives of Toxicology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77260-3_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-77260-3_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77262-7
Online ISBN: 978-3-642-77260-3
eBook Packages: Springer Book Archive