Animal Studies for Prediction of Chronic Toxicity
The aim of a chronic toxicity study is to administer the test substance for a long enough period for chronic effects to be realised. It may be equally important to determine the progression of effects seen in shorter term toxicity studies. The number of animals and dose levels should be sufficient to establish dose response characteristics and a no effect level. The range of examinations within the study should cover several parameters of toxicity and, where possible, examinations should be undertaken at intervals throughout the study to follow the development of any chronic effects.
KeywordsToxicity Cage Hydrocarbon Toxicology OECD
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- Farber T.M. (1987) Selection of a Maximum Tolerated Dose (MTD) in Oncogenicity Studies: A position document of the US Environmental Protection Agency Office of Pesticide Programs EPA 540/09–88–003, Washington DC.Google Scholar
- Gifap (1982) Position paper: Chronic Toxicity in the Dog, GIFAP bulletin 8(4).Google Scholar
- Hart R.W. and Chou M.W. (1991) Calorie Restrictions and Chemical Toxicity/Carcinogenesis, Proceedings of the First International Conference on Food, Nutrition and Chemical Toxicity, Surrey, UK (in press).Google Scholar
- Paynter O.E., Harris J.E., Burin G.J. and Jaeger R.B. (1985) Hazard Evaluation Division Standard Evaluation Procedure. Toxicity Potential: Guideline for Analysis and Evaluation of Sub-chronic and ChronicExposure Studies. EPA-540/9 85–020, United States Environmental Protection Agency, Washington DC.Google Scholar