Immunopathology of Herpes Simplex Virus Infections

  • M. Z. Doymaz
  • B. T. Rouse
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 179)


The great majority of accounts of immune mechanisms in virus infections have dealt with protective aspects, but it is evident that immune reactions against infected cells or viral antigens may cause tissue damage. Indeed, it is likely that, during clearance of most if not all viruses, an inflammatory reaction ensues after a T cell response is generated (MIMS 1983). It is perhaps a matter of semantics as to whether or not this should be described as immunopathology (IP). For the purpose of this review, IP will be considered as a chronic inflammatory reaction mediated primarily by the immune system that results in tissue damage or a change in immune function which is initiated and perhaps perpetuated by virus infections. Such situations result more commonly following infections with noncytopathic viruses which persist in an expressed form in the body (Sissons and Borysiewicz 1985). Although herpes simplex virus (HSV) is persistent, clearly it is not usually expressed, and productive infections are highly cytopathic. Consequently, HSV is unlikely to participate in many immunopathological situations. Before discussing these, our review briefly surveys the state of affairs with other agents which best indicate immunopathological disease mechanisms and which provide clues to understanding those processes that occur in HSV-induced IP.


Herpes Simplex Virus Herpes Simplex Virus Infection Herpetic Keratitis Lymphocytic Choriomeningitis Virus Herpes Simplex Keratitis 
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1992

Authors and Affiliations

  • M. Z. Doymaz
    • 1
  • B. T. Rouse
    • 1
  1. 1.Department of MicrobiologyCollege of Veterinary Medicine University of TennesseeKnoxvilleUSA

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