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Macrophages and Other Nonspecific Defenses: Role in Modulating Resistance Against Herpes Simplex Virus

  • L. Wu
  • P. S. Morahan
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 179)

Abstract

Nonspecific host resistance is provided by effector cell systems, including the mononuclear phagocytes, i.e., circulating monocytes, and tissue macrophages (MOs), natural killer (NK) cells, and polymorphonuclear granulocytes (PMNs). These cells, together with cytokines, play various roles at different stages in the pathogenesis of HSV infection (Morahan et al. 1985; Mogensen 1979). Immunomodulation of nonspecific resistance is one useful approach to control HSV infection (Morahan and Murasko 1989). It has been effective in reducing mortality against HSV infections in immunosuppressed animals (Morahan and Pinto 1991) and may be especially useful in combination with chemotherapy (Connell et al. 1985).

Keywords

Herpes Simplex Virus Intrinsic Resistance Immediate Early Adoptive Cell Transfer Antiviral Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abramson JS, Mills EL (1988) Depression of neutrophil function induction induced by viruses and its role in secondary microbial infections. Rev Infect Dis 10: 326–344PubMedCrossRefGoogle Scholar
  2. Albers I, Kirchner, Domke-Opitz I (1989) Resistance of human blood monocytes to infection with herpes simplex virus. Virology 169: 466–469PubMedCrossRefGoogle Scholar
  3. Ashkenazi M, Kohl S (1990) Reduced antibody-dependent cellular cytotoxicity to herpes simplex virus-infected cells of salivary polymorphonuclear leukocytes and inhibition of peripheral blood polymorphonuclear leukocyte cytotoxicity by saliva. J Immunol 144: 4781–4787PubMedGoogle Scholar
  4. Belardelli F, Vignaux F, Proietti E, Gresser I (1984) Injection of mice with antibody to interferon renders peritoneal macrophages permissive for vesicular stomatitis virus and encephalomyelitis virus. Proc Natl Acad Sci USA 81: 602–606PubMedCrossRefGoogle Scholar
  5. Ben-Hur T, Rosen-Wolff A, Lamade W, Darai G, Becker Y (1988) HSV-1 DNA sequence determining intraperitoneal pathogenicity in mice is required for transcription of viral immediate-early genes in macrophages. Virology 163: 397–404PubMedCrossRefGoogle Scholar
  6. Bingham EL, Fenger TW, Sugar A, Smith JW (1985) Dependence on antibody for production of chemiluminescence in polymorphonuclear leukocuytes by herpes simplex virus. Invest Opthalmol Vis Sci 26: 1236–1243Google Scholar
  7. Boddingius J, Dijkman H, Hendriksen E, Schift R, Stolz E (1987) HSV-2 replication sites, monocyte and lymphocytic cell infection and virion phagocytosis by neutrophils, in vesicular lesions on penile skin. J Cutan Pathol 14: 165–175PubMedCrossRefGoogle Scholar
  8. Bukowski JF, Welsh RM (1986) The role of natural killer cells and interferon in resistance to acute infection of mice with herpes simplex virus type 1. J Immunol 136: 3481–3485PubMedGoogle Scholar
  9. Cai W, Schaffer PA (1989) Herpes simplex virus type 1 ICPO plays a critical role in the de novo synthesis of infections virus following transfection of viral DNA. J Virol 63: 4579–4589PubMedGoogle Scholar
  10. Connell, EV, Cerruti RL, Trown PW (1985) Synergistic activity of combinations of recombinant human alpha interferon and acyclovir, administered concomittantly and in sequence, against a lethal herpes simplex virus type 2 infection in mice. Antimicrob Agents Chemother 28: 1–4PubMedGoogle Scholar
  11. Domke-Opitz I, Kirchner H (1990) Stimulation of macrophages by endotoxin results in the reactivation of a persistent herpes simplex virus infection. Scand J Immunol 32: 69–75PubMedCrossRefGoogle Scholar
  12. Drew WL, Mintz L, Hoo R, Finley TN (1979) Growth of herpes simplex virus and cytomegalovirus in cultured human alveolar macrophages. Am Rev Respir Dis 119: 287–291PubMedGoogle Scholar
  13. Ellermann-Eriksen S, Sommerlund M, Mogensen SC (1989) Differential sensitivity of macrophages from herpes simplex virus-resistant and-susceptible mice to respiratory burst priming by interferon-α/β. J Gen Virol 70: 2139–2147PubMedCrossRefGoogle Scholar
  14. Fitzgerald-Bocarsly P, Feldman M, Mendelsohn M, Carl S, Lopez C (1988) Human mononuclear cells which produce interferon-alpha during NK (HSV-FS) assay are HLA-DR positive cells distinct from cytplytic natural killer effectors. J Leukocyte Biol 43: 323–334PubMedGoogle Scholar
  15. Gonik B, Loftin KC, Tan NS, Crump J (1990) Immune modulation of natural killer cell cytotoxicity against herpes infected target cells in pregnancy. Am J Reprod Immunol 24: 95–98PubMedGoogle Scholar
  16. Greeser I, Tovey MG, Maury C, Bandu MT (1976) Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses. J Exp Med 144: 1316–1323CrossRefGoogle Scholar
  17. Habu S, Akamatsu K, Tamaoki N, Okumura K (1984) In vivo significance of NK cells on resistance against virus (HSV-1) infections in mice. J Immunol 133: 2743–2747PubMedGoogle Scholar
  18. Harris P, Ralph P (1985) Human leukemia models of myelo-monocytic development: A review of the HL-60 and U937 cell lines. J Leukocyte Biol 37: 407–422PubMedGoogle Scholar
  19. Hayashi K, Kurata T, Morishima T, Nassery T (1980) Analysis of the inhibitory effect of peritoneal macrophages on the spread of herpes simplex virus. Infect Immun 28: 350–358PubMedGoogle Scholar
  20. Hayward A, Laszlo M, Vafai A (1989) Human newborn natural killer cell responses to activation by monoclonal antibodies. J Immunol 142:1139–1143PubMedGoogle Scholar
  21. Hendrzak JA, Pinto AJ, Morahan PS (1991) Intrinsic resistance to HSV-1 infection in liver Kupffer cells and peritoneal macrophages from normal and immunomodulator-treated mice. Nat Immun Cell Growth Regul (in press)Google Scholar
  22. Howie SEM, Norval M, Maingay JP (1986) Alterations in epidermal handling of HSV-1 antigens in vitro induced by in vivo exposure to UV-B light. Immunology 57: 225–230PubMedGoogle Scholar
  23. Howie SEM, Ross JA, Norval M, Maingay JP (1987) In vivo modulation of antigen presentation generates Ts rather than TDH in HSV-1 infection. Immunology 60: 419–423PubMedGoogle Scholar
  24. Huberman E, Callaham MF (1979) Induction of terminal differentiation in human promonocytic leukemia cells by tumor promoting agents. Proc Natl Acad Sci USA 76: 1293–1297PubMedCrossRefGoogle Scholar
  25. Izumi KM, Stevens JG (1990) Molecular and biological characterization of a herpes simplex virus type 1 (HSV-1) neuroinvasiveness gene. J Exp Med 172: 487–496PubMedCrossRefGoogle Scholar
  26. Johnson RT (1964) The pathogenesis of herpes virus encephalitis. II. A cellular basis for the development of resistance with age. J Exp Med 120: 359–374PubMedCrossRefGoogle Scholar
  27. Joklik WK (1990) Interferons. In: Fields BN, Knipe DM et al. (eds) Virology, 2nd edn. Raven, New York, pp 393–410Google Scholar
  28. Kaplan, AM, J Brown, JM Collins, PS Morahan, MJ Snodgrass (1978) Mechanism of macrophage-mediated tumor cell cytotoxicity. J Immunol 121: 1781–1789PubMedGoogle Scholar
  29. Kemp LM, Estridge JK, Brennan A, Katz DR, Latchman DS (1990) Mononuclear phagocytes and HSV-1 infection: increased permissivity in differentiated U937 cells is mediated by post-transcriptional regulation of viral immediate-early gene expression. J Leukocyte Biol 47: 483–489PubMedGoogle Scholar
  30. Kleinerman ES, Snyderman R, Daniels CA (1974) Depression of human monocyte Chemotaxis by herpes simplex virus and influenza viruses. J Immunol 113: 1562–1567PubMedGoogle Scholar
  31. Klotzbucher A, Mittnacht S, Kirchner H, Jacobsen H (1990) Different effects of interferon-y and interferon-α/β on immediate early gene expression of HSV-1. Virology 197: 487–491CrossRefGoogle Scholar
  32. Koff WC, Showalter SD, Seniff DA, Hampar B (1983) Lysis of herpes-infected cells by macrophages activated with free or liposome-encapsulated lymphokine produced by a mouse T cell hybridoma. Infect Immun 42: 1067–1072PubMedGoogle Scholar
  33. Koff WC, Dunegan MA, Chakrabarty MK, Hampar B, Showalter SD (1987) Herpes simplex virus-induced suppression of macrophage-mediated tumoricidal activity in mouse macrophages. Cancer Res 47:.1534–1537PubMedGoogle Scholar
  34. Kohl S (1990) Protection against murine neonatal herpes simplex virus infection by lymphokine-treated human leukocytes. J Immunol 144: 307–312PubMedGoogle Scholar
  35. Kruse A, Kirchner, H, Zawatzky R, Domke-Opitz I (1989) In vitro development of bone-marrow-derived macrophages. Scand J Immunol 30: 731–740PubMedCrossRefGoogle Scholar
  36. Lazdins J, Alteri E, Cook KW, Burgin C, Gangemi JD (1990) Use of human monocytes in the evaluation of antiviral drugs: quantitation of HSV-1 cytopathic effects. Antiviral Res 13: 175–186PubMedCrossRefGoogle Scholar
  37. Leary K, Connor JR, Morahan PS (1985) Comparison of herpes simplex virus type 1 DNA replication and virus production in mouse bone marrow derived and resident peritoneal macrophages. J Gen Viral 66: 1123–1129CrossRefGoogle Scholar
  38. Lehrer Rl, Daher K, Ganz T, Selsted ME (1985) Direct inactivation of viruses by MCP-1 and MCP-2 natural peptide antibiotics from rabbit leukocytes. J Virol 54: 467–472PubMedGoogle Scholar
  39. Leibson PJ, Hunter-Laszlo M, Hayward AR (1986) Inhibition of herpes simplex virus type 1 replication in fibroblast cultures by human blood mononuclear cells. J Virol 57: 976–982PubMedGoogle Scholar
  40. Lewkowicz-Moss SJ, Shimeld C, Easty DL (1985) The response of Langerhans’ cells to a localized corneal inoculation of herpes simplex virus (HSV-1) in the mouse. Opthalmic Res 17: 202Google Scholar
  41. Linnavuori K, Hovi (1987) Herpes simplex virus as an inducer of interferon in human monocyte cultures. Antiviral Res 8: 201–208PubMedCrossRefGoogle Scholar
  42. Lodmell DL, Niwa A, Hayashi K, Notkins AL (1973) Prevention of cell-to-cell spread of herpes simplex virus by leukocytes. J Exp Med 137: 706–720PubMedCrossRefGoogle Scholar
  43. Lopez C, Ryshke R, Bennet M (1980) Marrow dependent cells depleted by 89Sr mediate genetic resistance to herpes simplex virus type 1 infections in mice. Infect Immun 28:1028–1032PubMedGoogle Scholar
  44. Mogensen SC (1979) Role of macrophages in natural resistance to virus infection. Microbiol Rev 43: 1–26PubMedGoogle Scholar
  45. Mogensen SC, Virelizier JL (1987) The interferon-macrophage alliance. Interferon 8: 55–80PubMedGoogle Scholar
  46. Moore RN, Larsen HS, Horohov DW, Rouse BT (1984) Endogenous regulation of macrophage proliferative expansion by colony stimulating factor-induced interferon, Science 223: 178–181PubMedCrossRefGoogle Scholar
  47. Morahan PS, Morse SS (1979) Macrophage-virus interactions. In: Proffitt M (ed) Virus-lymphocyte interactions: implications: for disease. Elsevier, New York, pp 17–35Google Scholar
  48. Morahan PS, Murasko DM (1989) Viral infections. In: Nelson D (ed) Natural immunity. Academic, Sydney, pp 557–586Google Scholar
  49. Morahan PS, Pinto AJ (1991) An historic overview of biologic response modifiers as antivirals. Can J Infect Dis (in press)Google Scholar
  50. Morahan PS, Mama S, Anaraki F, Leary K (1989) Molecular localization of abortive infection of resident peritoneal macrophages by herpes simplex virus type 1. J Virol 63 2300–2307PubMedGoogle Scholar
  51. Morahan PS, Morse SS, McGeorge MB (1980) Macrophage extrinsic antiviral activity during herpes simplex virus infection. J Gen Virol 46: 291–300PubMedCrossRefGoogle Scholar
  52. Morahan PS, Connor JR, Leary KR (1985) Viruses and the versatile macrophages. Br Med Bull 41: 15–21PubMedGoogle Scholar
  53. Morahan PS, Dempsy WL, Volkman A, Connor J (1986) Antimicrobial activity of various immuno-modulators: independence from normal levels of circulating monocytes and natural killer cells. Infect Immun 51: 87–93PubMedGoogle Scholar
  54. Morahan PS, Volkman A, Melnicoff M, Dempsey WL (1988) Macrophage heterogeneity. In: Heppner G, Fulton A (eds) Macrophages and cancer. CRC Press, Boca Raton, pp 1–25Google Scholar
  55. Morse SS, Morahan PS (1981) Activated macrophages mediate interferon-independent inhibition of herpes simplex virus. Cell Immunol 58: 72–84PubMedCrossRefGoogle Scholar
  56. Mosca JD, Bednarik DP, Raj NBK, Rosen CA, Sodroski JG, Haseltine WA, Pitha PM (1987) Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus. Nature 325: 67–70PubMedCrossRefGoogle Scholar
  57. Oldstone MBA (1989) Virus can cause disease in the absence of morphological evidence of cell injury: implication for uncovering new disease in the fulture. J Infect Dis 159: 384–389PubMedCrossRefGoogle Scholar
  58. Ohmann HB, Babiuk LAS (1985) Viral-bacterial pneumonia in calves: effect of bovine herpesvirus-1 on immunologic functions. J Infect Dis 151: 937–947CrossRefGoogle Scholar
  59. Ostrove JM, Leonard J, Weck KE, Rabson AB, Gendelman HE (1987) Activation of the human immunodeficiency virus by herpes simplex virus type 1. J Virol 61: 3726–3732PubMedGoogle Scholar
  60. Otani T, Mori R (1987) The effects of ultraviolet irradiation of the skin on herpes simplex virus infection: alteration in immune function mediated by epidermal cells and the course of infection. Arch Virol 96: 1–15PubMedCrossRefGoogle Scholar
  61. Pientong C, Weisshart K, Kuhn JE, Knopf C, Braun RW (1989) Replication of herpes simplex virus type 1 in differentiated human promyelocytic HL-60 cells. Virology 170: 468–476PubMedCrossRefGoogle Scholar
  62. Pinto AJ, Stewart D, van Rooijen N, Morahan PS (1991) Selective depletion of liver and splenic macrophages using liposomes encapsulating the drug dichloromethylene diphosphonate: effects on antimicrobial resistance. J Leukocyte Biol (in press)Google Scholar
  63. Plaeger-Marshall S, Wilson LA, Smith JW (1982) Permissiveness of rabbit monocytes and macrophages for herpes simplex virus type 1. Infect Immun 35: 151–156PubMedGoogle Scholar
  64. Plaeger-Marshall S, Wilson LA, Smith JW (1983) Alteration of rabbit alveolar and peritoneal macrophage function by herpes simplex virus. Infect Immun 41:1376–1379PubMedGoogle Scholar
  65. Plaeger-Marshall S, Auk BJ, Altenburger KM, Pizer LI, Johnston Jr RB, Stiehm ER (1989) Replication of herpes simplex virus in blood monocytes and placental macrophages from human neonates. Pediatr Res 26: 135–139PubMedCrossRefGoogle Scholar
  66. Rager-Zisman B, Quan PC, Rosner M, Moller JR, Bloom BR (1987) Role of NK cells in protection of mice against herpes simplex virus-1 infection. J Immunol 138: 884–883PubMedGoogle Scholar
  67. Rinaldo CR Jr (1990) Immune suppression by herpesviruses. Annu Rev Med 41: 331–338PubMedCrossRefGoogle Scholar
  68. Rosen H, Gordon S (1990) Adoptive transfer of fluorescence-lebelled cells shows that resident peritoneal macrophages are able to migrate into specialized lymphoid organs and inflammatory sites in the mouse. Eur J Immunol 20: 1251–1258PubMedCrossRefGoogle Scholar
  69. Rouse BT, Babiuk LA, Henson PM (1980) Neutrophils in antiviral immunity: inhibition of virus replication by a mediator produced by bovine neutrophils. J Infect Dis 141: 223–232PubMedCrossRefGoogle Scholar
  70. Salo RJ, Orgeta AP (1986) Effect of interferon on herpes simplex virus replication in mouse macro-phage-like cells lines. Antiviral Res 6:161–169PubMedCrossRefGoogle Scholar
  71. Sarmiento M (1988) Intrinsic resistance to viral infection: mouse macrophage restriction of herpes simplex virus replication. J Immunol 141: 2740–2748PubMedGoogle Scholar
  72. Schirmacher P, Worsdorfer M, Lübbe K, Falke D, Thoenes W, Dienes HP (1989) HSV hepatitis in the mouse: a light and electron microscopic study with immunohistology and in situ hybridization. Virchows Arch [B] 56: 351–361CrossRefGoogle Scholar
  73. Sheridan JF, Beck M, Smith CO, Aurelian L (1987) Reactivation of herpes simplex virus is associated with production of a low molecular weight factor that inhibits lymphokine activity in vitro. J Immunol 138: 1234–1239PubMedGoogle Scholar
  74. Sit MF, Tenney DJ, Rothstein JL, Morahan PS (1988) Effect of marophage activation on resistance of mouse peritoneal macrophages to infection with herpes simplex virus type 1 and 2. J Gen Virol 69: 1999–2010PubMedCrossRefGoogle Scholar
  75. Small JA, Bieberich C, Ghotbi Z, Hess J, Scangos J, Clements JE (1989) The visna virus long terminal repeat directs expression of a reporter gene in activated macrophages lymphocytes, and the central nervous system of transgenic mice. J Virol 63:1891–1896PubMedGoogle Scholar
  76. Snyderman R, Wohlenberg C, Notkins AL (1972) Inflammation and viral infection: chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus. J Infect Dis 126: 207–209PubMedCrossRefGoogle Scholar
  77. Sprecher E, Becker Y (1987) Skin Langerhans’ cells play essential role in the defense against HSV-1 infection. Arch Virol 91: 341–349CrossRefGoogle Scholar
  78. Stanton GJ, Jordan C, Hart A, Heard, Langford MP, Baron S (1987) Nondetectable levels of interferon gamma is a critical host defence during the first day of herpes simplex virus infection. Microb Pathog is 3:179–183CrossRefGoogle Scholar
  79. Stevens JG, Cook ML (1979) Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction. Am J Pathol 19–38Google Scholar
  80. Straub P, Domke I, Kirchner H, Jacobsen H, Panet A (1986) Synthesis of herpes simplex virus proteins and nucleic acids in interferon-treated macrophages. Virology 150: 411–418PubMedCrossRefGoogle Scholar
  81. Tang JL, Yamamoto M, Sakuma S, Mori R, Nagayama (1988) Presistent infection with herpes simplex virus type 1 in an la antigen-positive mouse macrophage cell line. Microbiol Immunol 32: 363–374PubMedGoogle Scholar
  82. Tenney DJ, Morahan PS (1991) Differentiation of the U937 macrophage cell line removes an early block of HSV-1 infection. Viral Immunol 4: 91–102PubMedCrossRefGoogle Scholar
  83. Trofatter KF Jr, Daniels CA, Williams RJ Jr, Gall SA (1979) Growth of type 2 herpes simplex virus in newborn and adult mononuclear leukocytes. Intervirology 11: 117–123PubMedCrossRefGoogle Scholar
  84. Townsend JJ, Collins PK (1986) Peripheral nervous system demyelination with herpes simplex virus. J Neuropathol Exp Neurol 45: 419–425PubMedCrossRefGoogle Scholar
  85. Van Strijp JAG, Van Kessel KPM, Van Der Tol ME, Verhoef J (1989a) Phagocytosis of herpes simplex virions by human granulocytes and monocytes. Arch Virol 104: 287–298PubMedCrossRefGoogle Scholar
  86. Van Strijp JAG, Van Kessel KPM, Van Der Tol ME, Verhoef J (1989b) Complement-mediated phagocytosis of herpes simplex virus by granulocytes. J Clin Invest 84: 107–112PubMedCrossRefGoogle Scholar
  87. Van Strijp JAG, Milternburg LAM, Van Der Tol ME, Van Kessel KPM, Fluit AC, Verhoef J (1990) Degradation of herpes simplex virions by human polymorphonuclear leukocytes and monocytes. J Gen Virol 71: 1205–1209PubMedCrossRefGoogle Scholar
  88. Van Strijp JAG, Van Der Tol ME, Miltenburg LAM, Van Kessel KPM, Verhoef J (1991) Tumor necrosis factor triggers granulocytes to internalize complement-coated virus particles. Immunology (in press)Google Scholar
  89. Welsh RM, Vargas-Cortes M (1991) Regulation and role of natural killer cells in virus infections. In: Lewis CE, Gee J O’DM (eds) The natural immune system. Oxford University Press, Oxford (in press)Google Scholar
  90. Wu L-X, Anaraki F, Morahan PS, Leary K (1990) Transient expression of virus-specific promoters in mouse resident peritoneal macrophages. J Leukocyte Biol 48: 229–236PubMedGoogle Scholar
  91. Wu L-X, Eisenstein TK, Morahan PS (1991) Effect of herpes simplex virus type 1 infection on cytokine gene expression in activated mouse macrophages. In: Walsh L, Block TM, Crowell RL, Jungkind DL (eds) Innovations in antiviral development and the detection of virus infection. Plenum, New York (in press)Google Scholar
  92. Yasumoto S, Okabe N, Mori R (1986) Role of epidermal Langerhans’ cells in resistance to herpes simplex virus infection. Arch Virol 90: 261–271PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin, Heidelberg 1992

Authors and Affiliations

  • L. Wu
    • 1
  • P. S. Morahan
    • 1
  1. 1.Department of Microbiology and ImmunologyThe Medical College of PennsylvaniaPhiladelphiaUSA

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