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Controlling Herpes Simplex Virus Infections: is Intracellular Immunization the Way of the Future?

  • Chapter
Herpes Simplex Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 179))

Abstract

The available approaches to the management of herpes simplex virus (HSV) infections currently consist primarily of chemotherapy and the possibility of preventive vaccination. In this review, we explore the potential of a third approach based on recent advances in molecular biology and genetic engineering which renders cells resistant to viral infection. This form of antiviral gene therapy, termed “intracellular immunization” by Baltimore (1988), involves the intracellular expression of a variety of molecular species specifically designed to inhibit targeted virus replication. The utility of such an approach lies in the direct application of knowledge pertaining to molecular mechanisms involved in viral pathogenesis to precisely interrupt lytic infection through the generation of virus-resistant cells. Such strategies may be particularly useful in the management of intracel-lular pathogens which are capable of evading the immune system or in circumstances in which knowledge of molecular pathogenic mechanisms far surpasses the ability to develop appropriate therapeutic drugs or vaccines. In this article, the basic concepts of intracellular immunization, relevant aspects of HSV molecular biology, and studies utilizing antiviral gene therapy to prevent HSV infection will be reviewed.

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Authors and Affiliations

  1. Department of Hematology, Bone Marrow Transplantation Service, City of Hope National Medical Center, Building W4 Room 404A 1500 East Duarte Road, 91010-0269, Duarte, CA, USA

    K. K. Wong Jr.

  2. Division of Pediatrics, City of Hope National Medical Center and Department of Molecular Genetics, Beckman Research Institute, 1500 East Duarte Road, 91010-0269, Duarte, CA, USA

    S. Chatterjee

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  1. K. K. Wong Jr.
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Editors and Affiliations

  1. Department of Microbiology, College of Veterinary Medicine, University of Tennessee, 37996-0845, Knoxville, TN, USA

    Barry T. Rouse BVSc, MSC, PhD

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© 1992 Springer-Verlag Berlin, Heidelberg

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Wong, K.K., Chatterjee, S. (1992). Controlling Herpes Simplex Virus Infections: is Intracellular Immunization the Way of the Future?. In: Rouse, B.T. (eds) Herpes Simplex Virus. Current Topics in Microbiology and Immunology, vol 179. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77247-4_10

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  • DOI: https://doi.org/10.1007/978-3-642-77247-4_10

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