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Pathogenesis of Shigellosis pp 45–64Cite as

Shigella Lipopolysaccharide: Structure, Genetics, and Vaccine Development

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 180))

Abstract

Lipopolysaccharide (LPS) is a compound macromolecule anchored in the outer leaflet of the outer membrane of Gram-negative bacteria (Fig. 1) and extending out from the cell into the external medium (for detailed reviews see Jann and Jann 1984; MäKELä and Stocker 1984). It is a major structural component of the cell surface, and it has been calculated that there are about 2.5 × 106 molecules per cell in Salmonella typhimurium, occupying some 45% of the surface of the outer membrane (Inouye 1979). Each LPS molecule is composed of three distinct structural segments, namely the innermost hydrophobic lipid A moiety, which constitutes the main lipid component of the outer leaflet of the asymmetrical outer membrane; the outermost O-specific polysaccharide (also called the O-antigen or somatic antigen), which consists of a short orlong linear polymer of an oligosaccharide repeat unit; and the core oligosaccharide, which links the O-antigen to the lipid A. LPS molecules interact structurally and functionally with a number of other cell surface components, including several outer membrane proteins (LUGTENBREG and van Alphen 1983; Nikaido and Vaara 1985).

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  1. Department of Microbiology, GBF, National Research Center for Biotechnology, Mascheroder Weg 1, 3300, Braunschweig, Federal Republic of Germany

    H. N. Brahmbhatt & K. N. Timmis

  2. Department of Clinical Bacteriology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden

    A. A. Lindberg

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    P. J. Sansonetti M.D

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© 1992 Springer-Verlag Berlin Heidelberg

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Brahmbhatt, H.N., Lindberg, A.A., Timmis, K.N. (1992). Shigella Lipopolysaccharide: Structure, Genetics, and Vaccine Development. In: Sansonetti, P.J. (eds) Pathogenesis of Shigellosis. Current Topics in Microbiology and Immunology, vol 180. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77238-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-77238-2_3

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  • Online ISBN: 978-3-642-77238-2

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