Dieses Kapitel behandelt die adenomatösen Polypen von Kolon und Rektum. Diese benignen Tumore sind von großer klinischer Bedeutung, da sie als Präkanzerosen anzusehen sind [96]. Nahezu alle kolorektalen Karzinome entwickeln sich aus zuvor benignen adenomatösen Polypen [34, 44, 91]. Die Umwandlung gutartiger Adenome in Malignome ist eine gut belegte Tatsache und in der Literatur als Adenom-Karzinom-Sequenz bekannt [26, 38, 92, 93].


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  1. 1.
    Agrez MV, Ready R, Ilstrup D, Beart RW (1982) Metachronous colorectal malignancies. Dis Colon Rectum 25/6: 569–574PubMedGoogle Scholar
  2. 2.
    Arthur JF (1968) Structure and significance of metaplastic nodules in the rectal mucosa. J Clin Pathol 21:735–743PubMedGoogle Scholar
  3. 3.
    Bacon HE, Eisenberg SW (1971) Papillary adenoma or villous tumor of the rectum and colon. Ann Surg 174: 1002–1008PubMedGoogle Scholar
  4. 4.
    Begelow B, Winkelman J (1964) Polyps of the colon and rectum. A review of 12 years’ experience and report of unusual case. Cancer 17: 1177–1186Google Scholar
  5. 5.
    Behringer GE (1970) Changing concept in the histo pathologic diagnosis of polypoid lesions of the colon. Dis Colon Rectum 13: 116–128PubMedGoogle Scholar
  6. 6.
    Berci G, Panish JF, Chapiro M, Corlin R (1974) Complications of colonoscopy and polypectomy. Report of the Southern California Society for Gastrointestinal Endoscopy. Gastroenterology 67: 584–585PubMedGoogle Scholar
  7. 7.
    Berg JW, Howel MA (1974) The geographic pathology of bowel cancer. Cancer 34: 807–814PubMedGoogle Scholar
  8. 8.
    Brandstatter G, Kratochvil P (1978) Early diagnosis of colonic-rectal neoplasms by detecting occult blood in the feces. Wien Med Wochenschr 128: 209–210Google Scholar
  9. 9.
    Bremond A, Collet P, Lambert R, Martin JL (1984) Breast cancer and polyps of the colon. A case-control study. Cancer 54: 2568–2570PubMedGoogle Scholar
  10. 10.
    Brief DK, Brener BJ, Goldenkranz R, Alpert J, Yalof I, Parsonnet V (1983) An argument for increased use of subtotal colectomy in the management of carcinoma of the colon. Am Surg 49: 66–72PubMedGoogle Scholar
  11. 11.
    Burkitt DP (1978) Colonic-rectal cancer: Fiber and other dietary factors. Am J Clin Nutr 31: 558–564Google Scholar
  12. 12.
    Burns FJ (1980) Synchronous and metachronous malignancies of the colon and rectum. Dis Colon Rectum 23: 578–589PubMedGoogle Scholar
  13. 13.
    Bussey HJR (1978) Multiple adenomas and carcinomas. Major Probl Pathol 10: 72–80PubMedGoogle Scholar
  14. 14.
    Bussey HJR, Morson BC (1978) Familial polyposis coli. In: Lipkin M, Good RA (eds) Gastrointestinal tract cancer. Plenum, New York, pp 275–294Google Scholar
  15. 15.
    Chapman I (1963) Adenomatous polypi of large intestine: incicence and distribution. Ann Surg 157: 223–226PubMedGoogle Scholar
  16. 16.
    Christie JP (1977) Colonoscopic excision of large sessile polyps. Am J Gastroenterol 67: 430–438PubMedGoogle Scholar
  17. 17.
    Christie JP (1984) Malignant colon polyps-cure by coloscopy or colectomy? Am J Gastroenterol 79: 543–547PubMedGoogle Scholar
  18. 18.
    Chu DZJ, Giacco G, Martin RG, Guinee VF (1986) The significance of synchronous carcinoma and polyps in the colon and rectum. Cancer 57: 445–450PubMedGoogle Scholar
  19. 19.
    Clark JC, Collan Y, Eide TJ et al. (1985) Prevalence of polyps in an autopsy series from areas with varing incidence of large bowel cancer. Int J Cancer 36: 179–196PubMedGoogle Scholar
  20. 20.
    Colacchio TA, Forde KA, Scantlebury VD (1981) Endoscopic polypectomy: inadequate treatment for invasive colorectal carcinoma. Ann Surg 194: 704–707PubMedGoogle Scholar
  21. 21.
    Coopers HS (1983) Surgical pathology of endoscopically removed malignant polyps of the colon and rectum. Am J Surg Pathol 7: 613–622Google Scholar
  22. 22.
    Correa P, Duques E, Cuello C, Haenszel W (1972) Polyps of the colon and rectum in Cali, Columbia. Int J Cancer 9: 86–96PubMedGoogle Scholar
  23. 23.
    Correa P, Strong JP, Johnson WD, Pizzolato P, Haenszel W (1982) Atherosclerosis and polyps of the colon. Quantification of precursors of coronary heart disease and colon cancer. J Chron Dis 35: 313–320PubMedGoogle Scholar
  24. 24.
    Coutsoftides T, Sivak MV, Benjamin SP, Jagelman D (1978) Colonoscopy and the management of polyps containing invasive carcinoma. Ann Surg 188: 638–641PubMedGoogle Scholar
  25. 25.
    Cunliffe WJ, HasletonPS, Tweedle DEF, Schofield PF (1984) Incidence of synchronous and metachronous colorectal carcinoma. Br J Surg 71: 941–943PubMedGoogle Scholar
  26. 26.
    Day DW, Morson BC (1978) Pathology of adenomas. In: Morson BC (ed) The pathogenesis of colorectal cancer. Volume 10. Major problems in pathology. Saunders, Philadelphia, pp 43–57Google Scholar
  27. 27.
    Dowling K, Watne A, Foshag L, Vargish T (1985) Management of nonfamilial adenomatous polyps and colon cancers. Surgery 98: 684–688PubMedGoogle Scholar
  28. 28.
    Dybdahl JH, Daae LNW, Larsen S, Myren J (1984) Occult faecal blood loss determined by a 51Cr method and chemical tests inpatients referred for colonoscopy. Scand J Gastroenterol 19: 245–254PubMedGoogle Scholar
  29. 29.
    Eide TJ, Stalsberg H (1978) Polyps of the large intestine in Northern Norway. Cancer 42: 2839–2848PubMedGoogle Scholar
  30. 30.
    Ekelund G (1963) On cancer and polyps of the colon and rectum. Acta Pathol Microbiol Scand 59: 165–170PubMedGoogle Scholar
  31. 31.
    Ekelund G, Phil B (1974) Multiple carcinomas of the colon and rectum. Cancer 33: 1630–1634PubMedGoogle Scholar
  32. 32.
    Elliot MJ, Louw JH (1979) A 10 year survey of large bowel carcinoma at Groote Schieur Hospital with particular reference to patients under 30 years of age. Br J Surg 66: 621–624PubMedGoogle Scholar
  33. 33.
    Enker WE, Dragacevics S (1978) Multiple carcinomas of the large bowel: A natural experiment in etiology and pathogenesis. Ann Surg 187: 8–11PubMedGoogle Scholar
  34. 34.
    Enterline HT, Evans GW, Mercado-Lugo R (1962) Malignant potential of adenomas of colon and rectum. JAMA 179: 322–330PubMedGoogle Scholar
  35. 35.
    Faivre J (1980) Die transanale Elektroresektion mit Hilfe eines analen Zuglappens bei Tumoren des Rektums. Proktologie 2: 77–80Google Scholar
  36. 36.
    Fechner RE (1973) Adenomatous polyps with submucosal cysts. Am J Clin Pathol 59: 498–502PubMedGoogle Scholar
  37. 37.
    Fenoglio CM, Kaye GI, Lane N (1973) Distribution of human lymphatics in normal, hyperplastic and adenomatous tissue: its relationship to metastases from small cancers in pedunculated adenomas. Gastroenterology 64: 51–66PubMedGoogle Scholar
  38. 38.
    Fenoglio CM, Lane N (1974) The anatomic precursor of colorectal carcinoma. Cancer 34: 819–823PubMedGoogle Scholar
  39. 39.
    Fenoglio CM, Pascal RP (1982) Colorectal adenomas and cancer: pathologic relationships. Cancer 50: 2601–2608PubMedGoogle Scholar
  40. 40.
    Fogler R, Weiner E (1980) Multiple foci of colorectal carcinoma: Argument for subtotal colectomy. NY State J Med 80: 47–51Google Scholar
  41. 41.
    Franchini A, Giardimo R, Cola B (1982) Multiple tu mors of the large bowel. Ann Gastroenterol Hepatol 18:309–311Google Scholar
  42. 42.
    Francillon J, Moulay A, Vignal J, Tissot E (1974) L’exérèse par voie basse des cancers de Tampoule rectale. Nouv Press Med 3: 1365–1366Google Scholar
  43. 43.
    Fraumeni JF, Lloyd JW, Smith EM, Wagoner JK (1969) Cancer mortality among nuns: role of marital status in etiology of neoplastic disease in women. J Natl Cancer Inst 42: 455–468PubMedGoogle Scholar
  44. 44.
    Fruhmorgen P, Matek W (1983) Significance of polypectomy in the large bowel. Endoscopy 15: 155–157PubMedGoogle Scholar
  45. 45.
    Fucim C, Spencer RJ (1986) An appraisal of endoscopic removal of malignant colonic polyps. Mayo Clin Proc 61: 123–126Google Scholar
  46. 46.
    Gilbertsen VA, Nelms JM (1978) The prevention of invasive cancer of the rectum. Cancer 41: 1137–1139PubMedGoogle Scholar
  47. 47.
    Greenburg AG, Saik RP, Coyle JJ, Peskin GW (1981) Mortality and gastrointestinal surgery in the aged. Arch Surg 116: 788–791PubMedGoogle Scholar
  48. 48.
    Greene FL (1974) Epithelial misdysplacement in adenomatous polyps of the colon and rectum. Cancer 33:206–217PubMedGoogle Scholar
  49. 49.
    Griffith CDM, Turner DJ, Saunders JH (1981) Falsenegative results of hemoccult test in colorectal cancer. Br Med 283: 472Google Scholar
  50. 50.
    Haenszel W, Correa P (1971) Cancer of the colon and rectum and adenomatous polyps. Cancer 28: 14–24PubMedGoogle Scholar
  51. 51.
    Haenszel W, Berg JW, Segi M, Kurihara M, Locke FB (1973) Large-bowel cancer in Hawaiian Japanse. J Natl Cancer Inst 51: 1765–1779PubMedGoogle Scholar
  52. 52.
    Haggit RC, Glotzbach RE, Soffer EE, Wruble LD (1985) Prognosis factors in colorectal carcinomas arising in adenomas: implications for lesions removed by endoscopic polypectomy. Gastroenterology 89: 328–336Google Scholar
  53. 53.
    Halney PH, Hines MO, Ray JE (1971) Villous tumors. Experience with 217 patients. Am Surg 37: 190–197Google Scholar
  54. 54.
    Heeb MA, Ahlvin RC (1978) Screening for colorectal carcinoma in a rural area. Surgery 83: 540–541PubMedGoogle Scholar
  55. 55.
    Heinrich HC (1982) Frühdiagnostik kolorektaler Polypen und Karzinome durch chemischen und/oder immunochemischen Okkultblut-Nachweis in Stuhl. Med Klin 77: 797–801Google Scholar
  56. 56.
    Henry GL, Condon RE, Schulte WJ, Aprahamian C, DeCosse JJ (1975) Risk of recurrence of colon polyps. Ann Surg 182: 511–515PubMedGoogle Scholar
  57. 57.
    Hermanek P, Karrer K, Sobin LH (1983) Statistics of adenomas. In: Hermanek P, Karrer K, Sobin LH (eds) Atlas of colorectal tumors. Butterworths, London, pp 58–59Google Scholar
  58. 58.
    Hermanek P, Karrer K, Sobin LH (1983) Early detection, screening. In: Hermanek P, Karrer K, Sobin LH (eds) Atlas of colorectal tumors. Butterworths, London, pp 134–136Google Scholar
  59. 59.
    Hill MJ (1974) Bacteria and ethiology of colonic cancer. Cancer 34: 815–818PubMedGoogle Scholar
  60. 60.
    Howell MA (1976) The association between colorectal cancer and breast cancer. J Chron Dis 29: 243–261PubMedGoogle Scholar
  61. 61.
    Jarvinen HJ, Ovaska J, Mecklin JP (1988) Improvements in the treatment and prognosis of colorectal carcinoma. Br J Surg 75: 25–27PubMedGoogle Scholar
  62. 62.
    Jass JR (1983) Relation between metaplastic polyp and carcinoma of the colorectum. Lancet i: 28–30Google Scholar
  63. 63.
    Jensen OM, MaClennan R (1979) Dietary factors and colorectal cancer in Scandinavia. Israel J Med Sci 15: 329–334PubMedGoogle Scholar
  64. 64.
    Johnson SM (1978) Colonoscopy and polypectomy. Am J Surg 136: 313–316PubMedGoogle Scholar
  65. 65.
    Kodaira S, Teramoto T, Ono S, Takizawa K, Katsumata T, Abe O (1981) Lymph node metastases from carcinomas developing in pedunculated and semipedunculated colorectal adenomas. Aust NZ J Surg 51: 429–433Google Scholar
  66. 66.
    Kodaira S, Ono S, Purri P et al. (1981) Endoscopic polypectomy of the large bowel: management of cancerbearing polyps. Int Surg 66: 311–314PubMedGoogle Scholar
  67. 67.
    Kraus FT (1965) Pedunculated adenomatous polyp with carcinoma in the tip and metastasis to lymph nodes. Dis Colon Rectum 8: 283–286PubMedGoogle Scholar
  68. 68.
    Kronborg O, Hage E, Adamsen S, Deichgraeber E (1983) Follow-up after colorectal polypectomy. II. Repeated examinations of the colon every six months after removal of sessile adenomas and adenomas with the highest degrease dysplasia. Scand J Gastroenterol 18: 1095–1099PubMedGoogle Scholar
  69. 69.
    Lane N, Lev R (1963) Observations on the origin of adenomatous epithelium of the colon. Cancer 16: 751–764PubMedGoogle Scholar
  70. 70.
    Lane N, Kaye GI (1967) Pedunculated adenomatous polpy of the colon with carcinoma, lymph node metastases, and suture line recurrence. Report of a case and discussion of terminology problems. Am J Clin Pathol 48: 170–182Google Scholar
  71. 71.
    Lane N, Kaplan H, Pascal RP (1971) Minute adenomatous and hyperplastic polyps of the colon: Divergent pattern of epithelial growth with specific associated mesenchymal changes. Gastroenterology 60: 537–551PubMedGoogle Scholar
  72. 72.
    Lane N, Fenoglio CM (1976) Observations on the adenoma as precursor to ordinary large bowel carcinoma. Gastrointest Radiol 1: 111–119PubMedGoogle Scholar
  73. 73.
    Leborgne J, Heloury Y, Leneel JC, Lenne Y, Malvy P (1984) Les cancers multiples colo-rectaux. Reflexions. A propos de 12 observations. Med Chir Dig 13: 605–612Google Scholar
  74. 74.
    Lillehei RC, Wangensteen OH (1955) Bowel function after colectomy for cancer, polyps and diverticulitis. JAMA 159: 163–170Google Scholar
  75. 75.
    Lipkin M (1974) Phase 1 and phase 2 proliferative lesions of colonic epithelial cells in diseases leading to colonic cancer. Cancer 34: 878–888PubMedGoogle Scholar
  76. 76.
    Lipper S, Kahn LB, Ackerman LV (1983) The significance of microscopic invasive cancer in endoscopically removed polyps, of the large bowel. Cancer 52: 1691–1699PubMedGoogle Scholar
  77. 77.
    Lockart-Mummery HE, Heald RJ, Chir M (1972) Metachronous cancer of the large intestine. Dis Colon Rectum 15: 261–264Google Scholar
  78. 78.
    Lovette E (1976) Family studies in cancer of the colon and rectum. Br J Surg 63: 13–18Google Scholar
  79. 79.
    Lynch HT, Lynch PM (1979) The cancer family syndrome. A pragmatic basis for syndrome identification. Dis Colon Rectum 22: 106–110PubMedGoogle Scholar
  80. 80.
    Manheimer LH (1965) Metastases to the liver from a colonic polyp. Report of a case. N Engl J Med 272: 144–145PubMedGoogle Scholar
  81. 81.
    Marshak RH (1965) The pedunculated adenomatous polyp. Am J Dig Dis 10: 958–967PubMedGoogle Scholar
  82. 82.
    Marti MC (1985) Transanal surgical treatment of rectal tumors. Acta Chir 52: 321–324Google Scholar
  83. 83.
    Maskens AP (1979) Histogenesis of adenomatous polyps in the human large intestine. Gastroenterology 77: 1245–1251PubMedGoogle Scholar
  84. 84.
    Maskens AP, Dujardin-Loits RM (1981) Experimental adenomas and carcinomas of the large intestive behave as distinct entities. Cancer 47: 81–89PubMedGoogle Scholar
  85. 85.
    McDermott FT, Hughes ESR, Pihl E, Johnson WR, Price AB (1985) Local recurrence after potentially curative resection for rectal cancer in a series of 1008 patients. Br J Surg 72: 34–37PubMedGoogle Scholar
  86. 86.
    McMichael AJ, McCall MG, Hartshorne JM, Woodings TL (1980) Patterns of gastro-intestinal cancer in European migrants to Australia: the role of dietary change. Int J Cancer 25: 431–437PubMedGoogle Scholar
  87. 87.
    Moertel CG, Bargen JA, Dockerty MB (1958) Multiple carcinomas of the large intestine: A review of the literature and a study of 261 cases. Gastroenterology 34: 85–98PubMedGoogle Scholar
  88. 88.
    Moertel CG, Hill JR, Dockerty MB (1966) Routine proctoscopic examination. Second look. Mayo Clin Proc 41: 368–374Google Scholar
  89. 89.
    Moreaux J, Catala M (1985) Les cancers multiples du colon et du rectum. Fréquence et résultats du traitement chirurgical. Gastroenterol Clin Biol 9: 336–341PubMedGoogle Scholar
  90. 90.
    Morson BC (1962) Some pecularities in the histology of intestinal polyps. Dis Colon Rectum 5: 337–344Google Scholar
  91. 91.
    Morson BC, Bussey HJR (1970) Predisposing causes of intestinal cancer. Curr Prob Surg 2: 1–50Google Scholar
  92. 92.
    Morson BC (1974) The polyp-cancer sequence in the large bowel. Proc R Soc Med 67: 451–457PubMedGoogle Scholar
  93. 93.
    Morson BC (1974) Evaluation of cancer of the colon and rectum. Cancer 34: 845–849PubMedGoogle Scholar
  94. 94.
    Morson BC, Sobin LH (1976) Histological typing of intestinal tumors. Geneva, World Health Organization, 13–58Google Scholar
  95. 95.
    Morson BC, Bussey HJR, Samoorian S (1977) Policy of local excision for early cancer of the colorectum. Gut 18: 1045–1050PubMedGoogle Scholar
  96. 96.
    Morson BC (1983) Markers for increased risk of colorectal cancer. In: Sherlock P, Morson BC, Veronesi BL (eds) Precancerous lesions of the gastrointestinal tract. Rosen, New York, pp 255–259Google Scholar
  97. 97.
    Morson BC (1984) The evolution of colorectal carcinoma. Clin Radiol 35: 425–431PubMedGoogle Scholar
  98. 98.
    Morson BC, Whiteway JE, Jones EA, Macrae FA, Williams CB (1984) Histopathology and prognosis of malignant colorectal polyps treated by endoscopic polypectomy. Gut 25: 437–444PubMedGoogle Scholar
  99. 99.
    Muto T, Bussey HJ, Morson BC (1975) The evolution of cancer of the colon and rectum. Cancer 36: 2251–2270PubMedGoogle Scholar
  100. 100.
    Muto T, Kamina J, Sawada T, Kusama S, Itai Y, Ikenaga T, Yamashiro M, Hino Y, Yamaguchi S (1970) Colonoscopic polypectomy in diagnosis and treatment of early carcinoma of the large intestine. Dis Colon Rectum 23: 68–75Google Scholar
  101. 101.
    Nava H, Carlsson G, Petrelli NJ, Herrera L, Mittelman A (1987) Follow-up colonoscopy in patients with colorectal adenomatous polyps. Dis Colon Rectum 30: 465–468PubMedGoogle Scholar
  102. 102.
    Neugut AI, Johnsen CM, Forde KA, Treat MR (1985) Recurrence rates for colorectal polyps. Cancer 55:1586–1589PubMedGoogle Scholar
  103. 103.
    Nivatvongs S, Goldberg SM (1978) Management of patients who have polyps containing invasive carcinoma removed via colonoscope. Dis Colon Rectum 21:8–16PubMedGoogle Scholar
  104. 104.
    Orringer MB, Eggleston JC (1972) Papillary (villous) adenomas of the colon and rectum. Surgery 72: 378–381PubMedGoogle Scholar
  105. 105.
    Overholt BF (1975) Colonoscopy: a review. Gastroenterology 68: 1308–1320PubMedGoogle Scholar
  106. 106.
    Owen RW, Thompson RH, Hill MJ, Wilpart M, Malinguet P, Roberfroid M (1987) The importance of the ratio of lithocholic to deoxycholic acid in large bowel carcinogenesis. Nutr Cancer 9: 68–71Google Scholar
  107. 107.
    Owen RW, Dodo M, Thompson RH, Hill MJ (1987) Fecal steroids and colorectal cancer. Nutr Cancer 9: 73–80PubMedGoogle Scholar
  108. 108.
    Palacios R, Wellman K (1966) Adenomatous polyps of the colon with adenocarcinoma and pulmonary metastases. Gastroenterology 51: 82–86PubMedGoogle Scholar
  109. 109.
    Panish JF (1979) Management of patients with polypoid lesions of the colon. Am J Gastroenterol 71: 315–324PubMedGoogle Scholar
  110. 110.
    Parks AG, Nicholls RJ (1983) Perianal endorectal operative techniques. In: Todd IP, Fielding LP (eds) Operative surgery. Colon, rectum and anus, 4th edn. Butterworths, London, pp 316–326Google Scholar
  111. 111.
    Parks AG, Stuart AG (1973) The management of villous tumors of the large bowel. Br J Surg 60: 688–695PubMedGoogle Scholar
  112. 112.
    Potter JD, McMichael AJ (1983) Large bowel cancer in women in relation to reproductive and hormonal factors: a case-control study. J Natl Cancer Inst 71: 703–709PubMedGoogle Scholar
  113. 113.
    Quan SHQ, Castro EB (1971) Papillary adenomas (villous tumors). A review of 215 cases. Dis Colon Rectum 14: 267–280PubMedGoogle Scholar
  114. 114.
    Raicht RF, Cohen BI, Fazzini EP, Sarwal AN, Takahashi M (1980) Protective effect of plant sterols against chemically induced colon tumors in rats. Cancer Res 40: 403–405PubMedGoogle Scholar
  115. 115.
    Reedy BS, Weisburger JH, Wynder EL (1974) Effect of dietary fat level and dimethylhydrazine on fecal acid and neutral sterol excretion and colon carcinogenesis in rats. J Natl Cancer Inst 52: 507–511Google Scholar
  116. 116.
    Reilly JC, Rusin LC, Theverkauf FJ (19829 Colonoscopy: its role in cancer of the colon and rectum. Dis Colon Rectum 25: 532–538PubMedGoogle Scholar
  117. 117.
    Ribet A, Escourrou J, Frexinos J, Delpu J (1980) Screening for colorectal tumors-results of two years experience. Cancer Detect Prev 3: 449–461PubMedGoogle Scholar
  118. 118.
    Rickert RR, Auerbach O, Garfinkel L, Hammond EC, Frasca JM (1979) Adenomatous lesions of the large bowel. An autopsy study. Cancer 43: 1847–1857PubMedGoogle Scholar
  119. 119.
    Rider JA, Kirsner JB, Moeller HC, Palmer WL (1959) Polyps of the colon and rectum. JAMA 170: 633–638Google Scholar
  120. 120.
    Rosenthal I, Baronofsky ID (1960) Prognostic and therapeutic implications of polyps in metachronous coli carcinoma. JAMA 172: 37–41Google Scholar
  121. 121.
    Rossini RP, Ferrari A, Coverlizza S (1982) Colonoscopic polypectomy in diagnosis and management of cancerous adenomas: an individual and multicentric experience. Endoscopy 14: 124–127PubMedGoogle Scholar
  122. 122.
    Scarborough RA (1960) The relationship between polyps and carcinoma of the colon and rectum. Dis Colon Rectum 3: 336–342PubMedGoogle Scholar
  123. 123.
    Shatney CH, Lober PH, Gilbertsen VA, Sosin H (1974) The treatment of pedunculated adenomatous colorectal polyps with focal cancer. Surg Gynecol Obstet 139: 845–850PubMedGoogle Scholar
  124. 124.
    Shinya H, Wolff WI (1979) Morphology, anatomic distribution and cancer potentional of colonic po lyps. An analysis of 7000 polyps endoscopically removed. Ann Surg 190: 679–683PubMedGoogle Scholar
  125. 125.
    Shinya H (1982) Colonoscopy: diagnosis and treatment of colonic diseases. Igaku-Shoin, New YorkGoogle Scholar
  126. 126.
    Soullard J, Potet F (1975) La prevention des cancers recto-coliques. Arch Fr Mal App Dig 64: 197–200PubMedGoogle Scholar
  127. 127.
    Stemmermann GN, Yatani R (1973) Diverticulosis and polyps of the large intestine. Cancer 31: 1260–1269PubMedGoogle Scholar
  128. 128.
    Thomson JS (1977) Treatment of sessile villous and tubovillous adenomas of the rectum. Experience of St. Mark’s Hospital. 1963–1972. Dis Colon Rectum 20: 467–472Google Scholar
  129. 129.
    Vatn MH, Stalsberg H (1982) The prevalence of polyps of the large intestine in Oslo: An autopsy study. Cancer 49: 819–825PubMedGoogle Scholar
  130. 130.
    Wattenberg LW, Loub WD (1978) Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res 38: 1410–1413PubMedGoogle Scholar
  131. 131.
    Waye JD, Braunfeld S (1982) Surveillance intervals after colonoscopic polypectomy. Endoscopy 14: 79–81PubMedGoogle Scholar
  132. 132.
    Weir JA (1975) Colorectal cancer. Metachronous and other associated neoplasma. Dis Colon Rectum 18: 4–5PubMedGoogle Scholar
  133. 133.
    Welch CE, Hedberg SE (1975) Polypoid lesions of the gastrointestinal tract, 2nd edn. Saunders, PhiladelphiaGoogle Scholar
  134. 134.
    Welch JP, Welch CE (1976) Villous adenomas of the colo-rectum. Am J Surg 131: 185–191PubMedGoogle Scholar
  135. 135.
    Welch JP (1981) Multiple colorectal tumors. Am J Surg 142: 274–280PubMedGoogle Scholar
  136. 136.
    Welin S (1967) Results of the Malmö technique of colon examination. JAMA 199: 369–371PubMedGoogle Scholar
  137. 137.
    Wilcox GM, Anderson PB, Colacchio TA (1986) Early invasive carcinoma in colonic polyps. A review of the literature with emphasis on the assessment of the risk of metastasis. Cancer 57: 160–171PubMedGoogle Scholar
  138. 138.
    Winawer SJ, Witt TR (1981) Cancer in a colonic polyp, or malignant colonic adenomasis polypectomy sufficient? Gastroenterology 81: 625–626Google Scholar
  139. 139.
    Winawer SJ (1981) Preventive screening and early diagnosis. In: DeCosse JJ (ed) Clinical surgery international: large bowel cancer. Churchill Livingstone, Edinburgh, pp 46–62Google Scholar
  140. 140.
    Winawer SJ, Sherlock P (1982) Surveillance for colorectal cancer in average-risk patients, familial highrisk groups, and patients with adenomas. Cancer 50: 2609–2614PubMedGoogle Scholar
  141. 141.
    Wolff WI, Shinya H (1973) A new approach to the management of colonic polyps. Adv Surg 7: 45–67PubMedGoogle Scholar
  142. 142.
    Wolff WI, Shinya H (1973) A new approach to colonic polyps. Ann Surg 178: 3Google Scholar
  143. 143.
    Wolff WI, Shinya H (1975) Definitive treatment of malignant polyps of the colon. Ann Surg 182: 516–524PubMedGoogle Scholar
  144. 144.
    Wynder EL, Reddy BS (1974) Metabolic epidemiology of colorectal cancer. Cancer 34: 801–806PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1992

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