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Fluorine-19F NMR Spectroscopy and Imaging In-Vivo

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In-Vivo Magnetic Resonance Spectroscopy III: In-Vivo MR Spectroscopy: Potential and Limitations

Part of the book series: NMR Basic Principles and Progress ((NMR,volume 28))

Abstract

The 19F nucleus is useful for studies using NMR in vivo as it has a high sensitivity and there is a low background signal from the body. The 19F nucleus has a wide range of chemical shifts which offer advantages for studies using 19F NMR spectroscopy, though they can be a problem for imaging experiments. Drugs, such as fluoropyrimidines, perfluoroearbon blood substitutes, anaesthetics and folate analogues which contain the 19F label, may be studied in animals and man. Information can be obtained by 19F NMR in vivo on the metabolism and biodistribution of these drugs. Furthermore, there are a number of fluorinated probes which may be used by 19F NMR in vivo to study the concentration of intracellular metal ions, pH, cellular hypoxia and glucose metabolism in the brain.

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Abbreviations

APTRA:

o-aminophenol-N,N,O-triacetic acid

BAPTA:

1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid

CB3988:

C2-desamino-C2-methyl-N10-propargyl-2′-trifluoromethyl-5,8-dideazafolie acid

CCl-103F:

3-(1,1,1,3,3,3-hexafluoroprop-2-oxy)-1-(2-nitroimidazol-1-yl)propan-2-ol

ED50 :

Dose of anaesthetic effective in 50% of cases

Fala:

fluorinated derivatives of α-methylalanine

F-anil:

N,N-(methyl-2-carboxyisopropyl)-4-fluoroaniline

FBALA:

α-fluoro-β-alanine

FBAPTA:

5,5′-difluoro-1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid

5FC:

5-fluorocytosine

Fcryp-1:

3,2–8,9-bis[1-fluoro-3,4-benzol]-14,15-[1-di(ethoxycarbonyl-methyl)amino-2-acetyl-4,5-benzol]-21-[3-di(ethoxycarbonyl-methyl)aminophenyl]-4,7,13,16-tetraoxa-1,10–21triazabicyclo[8,8,5]tricosane

FDG:

2-fluoro-2-deoxy-D-glucose

FDG-6-P:

2-fluoro-2-deoxy-D-glueose-6-phosphate

FdUDP:

5-fluoro-2′-deoxyuridine-5′-diphosphate

2′FdURD:

2′-deoxy-5-fluorouridine

5′FdURD:

5′-deoxy-5-fluorouridine

FdUTP:

5-fluoro-2′-deoxyuridine-5′-triphosphate

FNUC:

fluoronucleotide

Fquene:

8-[bis(ethoxycarbonylmethyl)amino]-6-fluoro-2-[trans-2[bis(ethoxycarbonylmethyl)amino]styryl]quinoline

Ftorafur:

R,S-1-[tetrahydro-2-furyl]-5-fluorouracil

5FU:

5-fluorouracil

FUH2 :

dihydrofluorouracil

FU-DNA:

deoxyribonucleic acid incorporating 5FU

FUDP:

5-fluorouridine-5′-diphosphate

FUMP:

5-fluorouridine-5′-monophosphate

FUPA:

Fluoroureidopropionic acid

FURD:

5-fluorouridine

FU-RNA:

ribo nucleic acid incorporating 5FU

FUTP:

5-fluorouridine-5′-triphosphate

hplc:

high pressure liquid chromatography

i.p.:

intraperitonial

ISIS:

image selected in vivo spectroscopy

i.v.:

intravenous

PET:

positron emission tomography

PCr:

phosphocreatine

PFCE:

perfluorocarbon emulsion

pKa:

acid/base dissociation constant

Pi:

inorganic phosphate

ppm:

parts per million

PRPP:

phosphoribosyl pyrophosphate

Quene 1:

1 8-[bis(ethoxycarbonylmethyl)amino]-6-methoxy-2-[trans-2[bis(ethoxycarbonylmethyl)amino]styryl]quinoline

Ro-07-0741:

3-fluoro-1-(2-nitroimidazole-1-yl)propan-2-ol

T 1 :

spin-lattice relaxation time

T 2 :

spin-spin relaxation time

TFT:

5-trifluorothymidine

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Authors and Affiliations

  1. Division of Biochemistry, CRC Biomedical Magnetic Resonance Research Group, St. George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK

    M. J. W. Prior, R. J. Maxwell & J. R. Griffiths

Authors
  1. M. J. W. Prior
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  2. R. J. Maxwell
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  3. J. R. Griffiths
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Editors and Affiliations

  1. Preclinical Research 386/206, Sandoz Pharma Ltd., Ch-4002, Basel, Switzerland

    M. Rudin

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Prior, M.J.W., Maxwell, R.J., Griffiths, J.R. (1992). Fluorine-19F NMR Spectroscopy and Imaging In-Vivo. In: Rudin, M. (eds) In-Vivo Magnetic Resonance Spectroscopy III: In-Vivo MR Spectroscopy: Potential and Limitations. NMR Basic Principles and Progress, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77218-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-77218-4_4

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