Spin-Trapping in Biological Systems

  • Claude Chopard
Conference paper


Spin trapping is a technique for detecting short-lived (reactive) free radicals. It consists in producing an ESR detectable (long-lived) radical by an addition reaction of the short-lived radical on a trapping agent. The spin trap is generally a nitrone or a nitroso compound. then the spin adduct an aminoxyl radical having at least a three lines spectrum. Nuclei having a magnetic moment can interact with the aminoxyl unpaired electron causing further hyperfine splitting whose constants can help to identify the trapped species.


Linoleic Acid Electron Spin Resonance Spin Trap Spin Adduct Eicosatetraenoic Acid 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Claude Chopard
    • 1
  1. 1.Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Unité associée au CNRS(URA 400), Université René DescartesParis Cedex 06France

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