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The respiratory-chain NADH dehydrogenase (complex I) of mitochondria

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EJB Reviews 1991

Part of the book series: EJB Reviews 1991 ((EJB REVIEWS,volume 1991))

Abstract

In mitochondria, electrons are transferred from NADH to O2 through a chain of three large enzyme complexes, namely NADH: ubiquinone oxidoreductase (NADH dehydrogenase or complex I), ubiquinol: ferricytochrome c oxidoreductase (cytochrome reductase or complex III), and ferrocytochrome c:O2 oxidoreductase (cytochrome oxidase or complex IV). The function of these enzyme complexes is to link electron transfer with proton translocation out of the mitochondrion. In doing so, they generate a transmembraneous proton motive force which subsequently drives ATP synthesis by the H+-ATPase (complex V, for a review see [1]).

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  1. Institut für Biochemie der Universität Düsseldorf, Federal Republic of Germany

    Hanns Weiss, Thorsten Friedrich, Götz Hofhaus & Dagmar Preis

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  1. Biochemisches Institut der Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland

    P. Christen

  2. Institut für Biochemie der Universität Leipzig, Liebigstraße 16, O-7010, Leipzig, Germany

    E. Hofmann

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Weiss, H., Friedrich, T., Hofhaus, G., Preis, D. (1991). The respiratory-chain NADH dehydrogenase (complex I) of mitochondria. In: Christen, P., Hofmann, E. (eds) EJB Reviews 1991. EJB Reviews 1991, vol 1991. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77200-9_5

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