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Structure/function relationship of proteins belonging to the family of receptors coupled to GTP-binding proteins

  • Arthur Donny Strosberg
Part of the EJB Reviews 1991 book series (EJB REVIEWS, volume 1991)

Abstract

The structural properties of a number of proteins belonging to the family of receptors coupled to GTP binding proteins are discussed in relation to their function.

Keywords

Adenylyl Cyclase Muscarinic Cholinergic Receptor Affinity Label Glucocorticoid Responsive Element A431 Epidermoid Carcinoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

βAR

β-adrenergic receptor

E-R7G

family of receptors having seven transmembrane domains, coupled to GTP binding proteins and having an extra long ≈ 333 residues) extracellular domain

G proteins

GTP binding regulatory proteins (Gi = inhibitory, Gs = stimulatory, Gp = coupled to phospholipase)

GRE

glucocorticoid responsive elements

5HT

5-hydroxytryptamine

m

muscarinic

R7G

family of receptors having seven transmembrane domains and coupled to GTP binding proteins

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References

  1. André, C., De Backer, J.-P., Guillet, J.-G., Vanderheyden, P., Vauquelin, G. & Strosberg, A. D. (1983) EMBO J. 2, 499–504.PubMedGoogle Scholar
  2. Ashkenazi, A., Peralta, E. G., Winslow, J. W., Ramachandran, J. & Capon, D. J. (1988) Cold Spring Harbor Symp. Quant. Biol. 53, 263–272.CrossRefPubMedGoogle Scholar
  3. Benovic, J. L., Regan, J. W., Matzui, H., Mayor Jr, F., Cotecchia, S., Leeb-Lundberg, L. M. F., Caron, M. G. & Lefkowitz, R. J. (1987) J. Biol. Chem. 262, 17251–17253.PubMedGoogle Scholar
  4. Bonner, T., Buckley, N. J., Young, A. C. & Brann, M. R. (1987) Science 237, 527–532.CrossRefPubMedGoogle Scholar
  5. Bonner, T. I., Young, A. C., Brann, M. R. & Buckley, N. J. (1988) Neuron 1, 403–410.CrossRefPubMedGoogle Scholar
  6. Bunzow, J. R., Van Tol, H. H. M., Grandy, D. K., Albert, P., Salon, J., Christie, M., Machida, C. A., Neve, K. A. & Civelli, O. (1988) Nature 556, 783–787.CrossRefGoogle Scholar
  7. Curtis, C. A. M., Wheatley, M., Bansal, S., Birdsall, N. J. M., Eveleigh, P., Pedder, E. K., Poyner, D. & Hulme, E. C. (1989) J. Biol. Chem. 264, 489.PubMedGoogle Scholar
  8. Dal Toso, R., Sommer, B., Ewert, M., Herb, A., Pritchett, D. B., Bach, A., Shivers, B. D. & Seeburg, P. H. (1989) EMBO J. 8, 4025–4034.Google Scholar
  9. Dixon, R. A. F., Kobilka, B. K., Strader, D. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. D., Rands, E., Diehl, R. F., Mumford, R. A., Slater, E. E., Sigal, L S., Caron, M. G., Lefkowitz, R. J. & Strader, C. D. (1986) Nature 321, 15–19.CrossRefGoogle Scholar
  10. Dixon, R. A. F., Sigal, I. S., Candelore, M. R., Register, R. B., Scattergood, W., Rands, E. & Strader, C. D. (1987a) EMBO J. 6, 3269–3275.PubMedGoogle Scholar
  11. Dixon, R. A. F., Sigal, I. S., Rands, E., Register, R. B., Candelore, M. R., Blake, A. D. & Strader, C. D. (1987b) Nature 326, 73–77.CrossRefPubMedGoogle Scholar
  12. Dixon, R. A. F., Sigal, I. S. & Strader, C. D. (1988) Cold Spring Harbor Symp. Quant. Biol. 53, 481–491.CrossRefGoogle Scholar
  13. Dohlman, H. G., Bouvier, M., Benovic, J. L., Caron, M. G. & Lefkowitz, R. J. (1987) J. Biol. Chem. 262, 14282–14288.PubMedGoogle Scholar
  14. Dohlman, H. G., Caron, M. G., Strader, C. D., Amlaïky, N. & Lefkowitz, R. J. (1988) Biochemistry 27, 1813–1817.CrossRefPubMedGoogle Scholar
  15. Dratz, E. A. & Hargrave, P. A. (1983) Trends Biochem. Sci. 8, 128–131.CrossRefGoogle Scholar
  16. Emorine, L. J., Marullo, S., Delavier-Klutchko, C., Kaveri, S. V., Durieu-Trautmann, O. & Strosberg, A. D. (1987) Proc. Natl. Acad. Sci. USA 84, 6995–6999.CrossRefPubMedGoogle Scholar
  17. Emorine, L. J., Marullo, S., Briend-Sutren, M. M., Patey, G., Tate, K., Delavier-Klutchko, C. & Strosberg, A. D. (1989) Science 245, 1118–1121.CrossRefPubMedGoogle Scholar
  18. Feve, B., Emorine, L. J., Briend-Sutren, M. M., Lasnier, F., Strosberg, A. D. & Pairault, J. (1990) J. Biol. Chem. 265, 16343–16349.PubMedGoogle Scholar
  19. Findlay, J. B. C. & Pappin, D. J. C. (1986) Biochem. J. 238, 625–642.PubMedGoogle Scholar
  20. Frielle, T., Collins, S., Daniel, K. W., Caron, M. G., Lefkowitz, R. J. & Kobilka, B. K. (1987) Proc. Natl Acad. Sci. USA 84, 7920–7924.CrossRefPubMedGoogle Scholar
  21. Frielle, T., Daniel, K. W., Caron, M. G. & Lefkowitz, R. J. (1988) Proc. Natl. Acad. Sci. USA 85, 9494–9498.CrossRefPubMedGoogle Scholar
  22. Giros, B., Sokoloff, P., Martres, M. P., Riou, J. F., Emorine, L. J. & Schwartz, J. C. (1989) Nature 342, 923–926.CrossRefPubMedGoogle Scholar
  23. Imoto, Y., Yatani, A., Reeves, J. P., Codina, J., Birnbaumer, L. & Brown, A. M. (1988) Am. J. Physiol. 255, H722–H728.PubMedGoogle Scholar
  24. Jackson, T. R., Blair, L. A. C., Marshall, J., Goedert, M. & Hanley, M. R. (1988) Nature 335, 437–440.CrossRefPubMedGoogle Scholar
  25. Julius, D., MacDermott, A. B., Axel, R. & Jessell, T. M. (1988) Science 247, 558–564.CrossRefGoogle Scholar
  26. Kobilka, B. K., Matsui, H., Kobilka, T. S., Yang-Feng, T. L., Francke, U., Caron, M. G., Lefkowitz, R. J. & Regan, J. W. (1987 a) Science 238, 650–656.CrossRefPubMedGoogle Scholar
  27. Kobilka, B. K., Dixon, R. A. F., Frielle, T., Dohlman, H. G., Bolanowski, M. A., Sigal, I. S., Yang-Feng, T. L., Francke, U., Caron, M. G. & Lefkowitz, R. J. (1987 b) Proc. Natl Acad. Sci. USA 84, 46–50.CrossRefPubMedGoogle Scholar
  28. Kobilka, B. K., Kobilka, T. S., Daniel, K., Regan, J. W., Caron, M. G. & Lefkowitz, R. J. (1988) Science 240, 1310–1316.CrossRefPubMedGoogle Scholar
  29. Kubo, T., Bujo, H., Akiba, L, Nakai, J., Mishima, M. & Numa, S. (1988) FEBS Lett. 241, 119–125.CrossRefPubMedGoogle Scholar
  30. Kuroda, M., Honnor, R. C., Cushman, S. W., Londos, C. & Simpson, I. A. (1987) J. Biol. Chem. 262, 245–253.PubMedGoogle Scholar
  31. Lefkowitz, R. J. & Caron, M. G. (1988) J. Biol. Chem. 263, 4993–4996.PubMedGoogle Scholar
  32. Lefkowitz, R. J., Kobilka, B. K., Benovic, J. L., Bouvier, M., Cotecchia, S., Hausdorff, W. P., Dohlman, H. G., Regan, J. W. & Caron, M. G. (1988) Cold Spring Harbor Symp. Quant. Biol. 53, 507–514.CrossRefPubMedGoogle Scholar
  33. Littman, B. J., Aton, B. & Hartley, J. B. (1982) Vision Res. 22, 1439–1442.CrossRefGoogle Scholar
  34. Lodish, H. F. (1988) Trends Biochem. Sci. 13, 332–334.CrossRefPubMedGoogle Scholar
  35. Loosfelt, H., Misrahi, M., Atger, M., Salesse, R., Tu Vu Hai-Luu Thi, M., Jolivet, A., Guiochon-Mantel, A., Sar, S., Jallal, B., Garnier, J. & Milgrom, E. (1989) Science 245, 525–528.CrossRefPubMedGoogle Scholar
  36. Maguire, M. E. & Erdos, J. J. (1980) J. Biol. Chem. 255, 1030–1035.PubMedGoogle Scholar
  37. Masu, Y., Nakayama, K., Tamaki, H., Harada, Y., Kuno, M. & Nakanishi, S. (1987) Nature 329, 836–838.CrossRefPubMedGoogle Scholar
  38. Matsui, H., Lefkowitz, R. J., Caron, M. G. & Regan, J. W. (1989) Biochemistry 28, 4125–4130.CrossRefPubMedGoogle Scholar
  39. Mattera, R., Graziano, M. P., Yatani, A., Zhou, Z., Graf, R., Codina, J., Birnbaumer, L., Gilman, A. G. & Brown, A. M. (1989) Science 245, 804–806.CrossRefGoogle Scholar
  40. Marullo, S., Delavier-Klutchko, C., Eshdat, Y., Strosberg, A. D. & Emorine, L. J. (1988) Proc. Natl Acad. Sci. USA 85, 7551–7555.CrossRefPubMedGoogle Scholar
  41. Marullo, S., Delavier-Klutchko, C., Guillet, J.-G., Charbit, A., Strosberg, A. D. & Emorine, L. J. (1989) Bio/Technology 7, 923–927.CrossRefGoogle Scholar
  42. Marullo, S., Emorine, L., Strosberg, A. D. & Delavier-Klutchko, C. (1990) EMBO J. 9, 1471–1476.PubMedGoogle Scholar
  43. McFarland, K. C., Sprengel, R., Phillips, H. S., Köhler, M., Rosemblit, N., Nikolics, K., Segaloff, D. L. & Seeburg, P. H. (1989) Science 245, 494–499.CrossRefPubMedGoogle Scholar
  44. Moereels, H., De Bie, L. & Tollenaere, J. P. (1990) J. Comp. Aided. Mol. Design 4, 131–145.CrossRefGoogle Scholar
  45. Monsma Jr, F. J., McVittie, L. D., Gerfen, C. R., Mahan, L. C. & Sibley, D. R. (1989) Nature 342, 926–928.CrossRefPubMedGoogle Scholar
  46. O’Dowd, B. F., Hnatowich, M., Caron, M. G., Lefkowitz, R. J. & Bouvier, M. (1989) J. Biol. Chem. 264, 7564–7569.PubMedGoogle Scholar
  47. Payne, G. S., Baker, D., Van Tuinen, E. & Scheckman, R. (1988) J. Cell. Biol. 106, 1453–1456.CrossRefPubMedGoogle Scholar
  48. Peralta, E. G., Winslow, J. W., Peterson, G. L., Smith, D. H., Ashkenazi, A., Ramachandran, J., Schimerlik, M. I. & Capon, D. J. (1987) Science 236, 600–605.CrossRefPubMedGoogle Scholar
  49. Perkins, J. P., Toews, M. L. & Harden, T. K. (1984) Adv. Cyclic Nucleotide Protein Phosphorylation Res. 17, 37–46.PubMedGoogle Scholar
  50. Pritchett, D. B., Bach, A. W. J., Wozny, M., Taleb, O., Dal Toso, R., Shih, J. & Seeburg, P. H. (1988) EMBO J. 7, 4135–4140.PubMedGoogle Scholar
  51. Raposo, G., Marullo, S., Dunia, L, André, C., Guillet, J.-G., Strosberg, A. D., Benedetti, E. L. & Hoebeke, J. (1987) Biol. Cell 60, 111–124.CrossRefGoogle Scholar
  52. Raposo, G., Dunia, I., Delavier-Klutchko, C., Kaveri, S., Strosberg, A. D. & Benedetti, E. L. (1989) Eur. J. Cell Biol. 50, 340–352.PubMedGoogle Scholar
  53. Regan, J. W., Nakata, H., DeMarinis, R. M., Caron, M. G. & Lefkowitz, R. J. (1986) J. Biol. Chem. 261, 3894–3900.PubMedGoogle Scholar
  54. Ross, E. M. (1989) Neuron 3, 141–152.CrossRefPubMedGoogle Scholar
  55. Sokoloff, P., Giros, B., Martres, M. P., Bouthenet, M. L. & Schwartz, J. C. (1990) Nature 347, 146–151.CrossRefPubMedGoogle Scholar
  56. Strader, C. D., Sigal, I. S., Register, R. B., Candelore, M. R., Rands, E. & Dixon, R. A. F. (1987 a) Proc. Natl Acad. Sci. USA 84, 4384–4388.CrossRefPubMedGoogle Scholar
  57. Strader, C. D., Dixon, R. A. F., Cheung, A. H., Candelore, M. R., Blake, A. D. & Sigal, I. S. (1987b) J. Biol. Chem. 262, 16439–16443.PubMedGoogle Scholar
  58. Strader, C. D., Candelore, M. R., Hill, W. S., Dixon, R. A. F. & Sigal, I. S. (1989) J. Biol. Chem. 264, 16470–16477.PubMedGoogle Scholar
  59. Takemoto, D. J., Takemoto, L. J., Hansen, J. & Morrison, D. (1985) Biochem. J. 232, 669–672.PubMedGoogle Scholar
  60. Tate, K., Briend-Sutren, M. M., Emorine, L. J., Delavier-Klutchko, C., Marullo, S. & Strosberg, A. D. (1991) Eur. J. Biochem (In press).Google Scholar
  61. Vauquelin, G., Geynet, P., Hanoune, J. & Strosberg, A. D. (1977) Proc. Natl. Acad. Sci. USA 74, 3710–3714.CrossRefPubMedGoogle Scholar
  62. Vauquelin, G., Geynet, P., Hanoune, J. & Strosberg, A. D. (1979a) Eur. J. Biochem. 98, 543–556.CrossRefPubMedGoogle Scholar
  63. Vauquelin, G., Bottari, S., Kanarek, L. & Strosberg, A. D. (1979b) J. Biol. Chem. 254, 4462–4469.PubMedGoogle Scholar
  64. Wong, S. K. F., Slaughter, C., Ruoho, A. E. & Ross, E. M. (1988) J. Biol. Chem. 263, 7925–7928.PubMedGoogle Scholar
  65. Yatani, A., Codina, J., Brown, A. M. & Birnbaumer, L. (1987) Science 255, 1288–1292.CrossRefGoogle Scholar
  66. Yatani, A., Imoto, Y., Codina, J., Hamilton, S. L., Brown, A. M. & Birnbaumer, L. (1988) J. Biol. Chem. 263, 9887–9895.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Arthur Donny Strosberg
    • 1
  1. 1.Laboratoire d’Immuno-Pharmacologie Moléculaire, CNRSUniversité Paris VII and Institut Cochin de Génétique MoléculaireParisFrance

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