Skip to main content

Structure/function relationship of proteins belonging to the family of receptors coupled to GTP-binding proteins

  • Chapter
  • 222 Accesses

Part of the book series: EJB Reviews 1991 ((EJB REVIEWS,volume 1991))

Abstract

The structural properties of a number of proteins belonging to the family of receptors coupled to GTP binding proteins are discussed in relation to their function.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

βAR:

β-adrenergic receptor

E-R7G:

family of receptors having seven transmembrane domains, coupled to GTP binding proteins and having an extra long ≈ 333 residues) extracellular domain

G proteins:

GTP binding regulatory proteins (Gi = inhibitory, Gs = stimulatory, Gp = coupled to phospholipase)

GRE:

glucocorticoid responsive elements

5HT:

5-hydroxytryptamine

m:

muscarinic

R7G:

family of receptors having seven transmembrane domains and coupled to GTP binding proteins

References

  • André, C., De Backer, J.-P., Guillet, J.-G., Vanderheyden, P., Vauquelin, G. & Strosberg, A. D. (1983) EMBO J. 2, 499–504.

    PubMed  Google Scholar 

  • Ashkenazi, A., Peralta, E. G., Winslow, J. W., Ramachandran, J. & Capon, D. J. (1988) Cold Spring Harbor Symp. Quant. Biol. 53, 263–272.

    Article  CAS  PubMed  Google Scholar 

  • Benovic, J. L., Regan, J. W., Matzui, H., Mayor Jr, F., Cotecchia, S., Leeb-Lundberg, L. M. F., Caron, M. G. & Lefkowitz, R. J. (1987) J. Biol. Chem. 262, 17251–17253.

    CAS  PubMed  Google Scholar 

  • Bonner, T., Buckley, N. J., Young, A. C. & Brann, M. R. (1987) Science 237, 527–532.

    Article  CAS  PubMed  Google Scholar 

  • Bonner, T. I., Young, A. C., Brann, M. R. & Buckley, N. J. (1988) Neuron 1, 403–410.

    Article  CAS  PubMed  Google Scholar 

  • Bunzow, J. R., Van Tol, H. H. M., Grandy, D. K., Albert, P., Salon, J., Christie, M., Machida, C. A., Neve, K. A. & Civelli, O. (1988) Nature 556, 783–787.

    Article  Google Scholar 

  • Curtis, C. A. M., Wheatley, M., Bansal, S., Birdsall, N. J. M., Eveleigh, P., Pedder, E. K., Poyner, D. & Hulme, E. C. (1989) J. Biol. Chem. 264, 489.

    CAS  PubMed  Google Scholar 

  • Dal Toso, R., Sommer, B., Ewert, M., Herb, A., Pritchett, D. B., Bach, A., Shivers, B. D. & Seeburg, P. H. (1989) EMBO J. 8, 4025–4034.

    Google Scholar 

  • Dixon, R. A. F., Kobilka, B. K., Strader, D. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. D., Rands, E., Diehl, R. F., Mumford, R. A., Slater, E. E., Sigal, L S., Caron, M. G., Lefkowitz, R. J. & Strader, C. D. (1986) Nature 321, 15–19.

    Article  Google Scholar 

  • Dixon, R. A. F., Sigal, I. S., Candelore, M. R., Register, R. B., Scattergood, W., Rands, E. & Strader, C. D. (1987a) EMBO J. 6, 3269–3275.

    CAS  PubMed  Google Scholar 

  • Dixon, R. A. F., Sigal, I. S., Rands, E., Register, R. B., Candelore, M. R., Blake, A. D. & Strader, C. D. (1987b) Nature 326, 73–77.

    Article  CAS  PubMed  Google Scholar 

  • Dixon, R. A. F., Sigal, I. S. & Strader, C. D. (1988) Cold Spring Harbor Symp. Quant. Biol. 53, 481–491.

    Article  Google Scholar 

  • Dohlman, H. G., Bouvier, M., Benovic, J. L., Caron, M. G. & Lefkowitz, R. J. (1987) J. Biol. Chem. 262, 14282–14288.

    CAS  PubMed  Google Scholar 

  • Dohlman, H. G., Caron, M. G., Strader, C. D., Amlaïky, N. & Lefkowitz, R. J. (1988) Biochemistry 27, 1813–1817.

    Article  CAS  PubMed  Google Scholar 

  • Dratz, E. A. & Hargrave, P. A. (1983) Trends Biochem. Sci. 8, 128–131.

    Article  CAS  Google Scholar 

  • Emorine, L. J., Marullo, S., Delavier-Klutchko, C., Kaveri, S. V., Durieu-Trautmann, O. & Strosberg, A. D. (1987) Proc. Natl. Acad. Sci. USA 84, 6995–6999.

    Article  CAS  PubMed  Google Scholar 

  • Emorine, L. J., Marullo, S., Briend-Sutren, M. M., Patey, G., Tate, K., Delavier-Klutchko, C. & Strosberg, A. D. (1989) Science 245, 1118–1121.

    Article  CAS  PubMed  Google Scholar 

  • Feve, B., Emorine, L. J., Briend-Sutren, M. M., Lasnier, F., Strosberg, A. D. & Pairault, J. (1990) J. Biol. Chem. 265, 16343–16349.

    CAS  PubMed  Google Scholar 

  • Findlay, J. B. C. & Pappin, D. J. C. (1986) Biochem. J. 238, 625–642.

    CAS  PubMed  Google Scholar 

  • Frielle, T., Collins, S., Daniel, K. W., Caron, M. G., Lefkowitz, R. J. & Kobilka, B. K. (1987) Proc. Natl Acad. Sci. USA 84, 7920–7924.

    Article  CAS  PubMed  Google Scholar 

  • Frielle, T., Daniel, K. W., Caron, M. G. & Lefkowitz, R. J. (1988) Proc. Natl. Acad. Sci. USA 85, 9494–9498.

    Article  CAS  PubMed  Google Scholar 

  • Giros, B., Sokoloff, P., Martres, M. P., Riou, J. F., Emorine, L. J. & Schwartz, J. C. (1989) Nature 342, 923–926.

    Article  CAS  PubMed  Google Scholar 

  • Imoto, Y., Yatani, A., Reeves, J. P., Codina, J., Birnbaumer, L. & Brown, A. M. (1988) Am. J. Physiol. 255, H722–H728.

    CAS  PubMed  Google Scholar 

  • Jackson, T. R., Blair, L. A. C., Marshall, J., Goedert, M. & Hanley, M. R. (1988) Nature 335, 437–440.

    Article  CAS  PubMed  Google Scholar 

  • Julius, D., MacDermott, A. B., Axel, R. & Jessell, T. M. (1988) Science 247, 558–564.

    Article  Google Scholar 

  • Kobilka, B. K., Matsui, H., Kobilka, T. S., Yang-Feng, T. L., Francke, U., Caron, M. G., Lefkowitz, R. J. & Regan, J. W. (1987 a) Science 238, 650–656.

    Article  CAS  PubMed  Google Scholar 

  • Kobilka, B. K., Dixon, R. A. F., Frielle, T., Dohlman, H. G., Bolanowski, M. A., Sigal, I. S., Yang-Feng, T. L., Francke, U., Caron, M. G. & Lefkowitz, R. J. (1987 b) Proc. Natl Acad. Sci. USA 84, 46–50.

    Article  CAS  PubMed  Google Scholar 

  • Kobilka, B. K., Kobilka, T. S., Daniel, K., Regan, J. W., Caron, M. G. & Lefkowitz, R. J. (1988) Science 240, 1310–1316.

    Article  CAS  PubMed  Google Scholar 

  • Kubo, T., Bujo, H., Akiba, L, Nakai, J., Mishima, M. & Numa, S. (1988) FEBS Lett. 241, 119–125.

    Article  CAS  PubMed  Google Scholar 

  • Kuroda, M., Honnor, R. C., Cushman, S. W., Londos, C. & Simpson, I. A. (1987) J. Biol. Chem. 262, 245–253.

    CAS  PubMed  Google Scholar 

  • Lefkowitz, R. J. & Caron, M. G. (1988) J. Biol. Chem. 263, 4993–4996.

    CAS  PubMed  Google Scholar 

  • Lefkowitz, R. J., Kobilka, B. K., Benovic, J. L., Bouvier, M., Cotecchia, S., Hausdorff, W. P., Dohlman, H. G., Regan, J. W. & Caron, M. G. (1988) Cold Spring Harbor Symp. Quant. Biol. 53, 507–514.

    Article  CAS  PubMed  Google Scholar 

  • Littman, B. J., Aton, B. & Hartley, J. B. (1982) Vision Res. 22, 1439–1442.

    Article  Google Scholar 

  • Lodish, H. F. (1988) Trends Biochem. Sci. 13, 332–334.

    Article  CAS  PubMed  Google Scholar 

  • Loosfelt, H., Misrahi, M., Atger, M., Salesse, R., Tu Vu Hai-Luu Thi, M., Jolivet, A., Guiochon-Mantel, A., Sar, S., Jallal, B., Garnier, J. & Milgrom, E. (1989) Science 245, 525–528.

    Article  CAS  PubMed  Google Scholar 

  • Maguire, M. E. & Erdos, J. J. (1980) J. Biol. Chem. 255, 1030–1035.

    CAS  PubMed  Google Scholar 

  • Masu, Y., Nakayama, K., Tamaki, H., Harada, Y., Kuno, M. & Nakanishi, S. (1987) Nature 329, 836–838.

    Article  CAS  PubMed  Google Scholar 

  • Matsui, H., Lefkowitz, R. J., Caron, M. G. & Regan, J. W. (1989) Biochemistry 28, 4125–4130.

    Article  CAS  PubMed  Google Scholar 

  • Mattera, R., Graziano, M. P., Yatani, A., Zhou, Z., Graf, R., Codina, J., Birnbaumer, L., Gilman, A. G. & Brown, A. M. (1989) Science 245, 804–806.

    Article  Google Scholar 

  • Marullo, S., Delavier-Klutchko, C., Eshdat, Y., Strosberg, A. D. & Emorine, L. J. (1988) Proc. Natl Acad. Sci. USA 85, 7551–7555.

    Article  CAS  PubMed  Google Scholar 

  • Marullo, S., Delavier-Klutchko, C., Guillet, J.-G., Charbit, A., Strosberg, A. D. & Emorine, L. J. (1989) Bio/Technology 7, 923–927.

    Article  CAS  Google Scholar 

  • Marullo, S., Emorine, L., Strosberg, A. D. & Delavier-Klutchko, C. (1990) EMBO J. 9, 1471–1476.

    CAS  PubMed  Google Scholar 

  • McFarland, K. C., Sprengel, R., Phillips, H. S., Köhler, M., Rosemblit, N., Nikolics, K., Segaloff, D. L. & Seeburg, P. H. (1989) Science 245, 494–499.

    Article  CAS  PubMed  Google Scholar 

  • Moereels, H., De Bie, L. & Tollenaere, J. P. (1990) J. Comp. Aided. Mol. Design 4, 131–145.

    Article  CAS  Google Scholar 

  • Monsma Jr, F. J., McVittie, L. D., Gerfen, C. R., Mahan, L. C. & Sibley, D. R. (1989) Nature 342, 926–928.

    Article  CAS  PubMed  Google Scholar 

  • O’Dowd, B. F., Hnatowich, M., Caron, M. G., Lefkowitz, R. J. & Bouvier, M. (1989) J. Biol. Chem. 264, 7564–7569.

    PubMed  Google Scholar 

  • Payne, G. S., Baker, D., Van Tuinen, E. & Scheckman, R. (1988) J. Cell. Biol. 106, 1453–1456.

    Article  CAS  PubMed  Google Scholar 

  • Peralta, E. G., Winslow, J. W., Peterson, G. L., Smith, D. H., Ashkenazi, A., Ramachandran, J., Schimerlik, M. I. & Capon, D. J. (1987) Science 236, 600–605.

    Article  CAS  PubMed  Google Scholar 

  • Perkins, J. P., Toews, M. L. & Harden, T. K. (1984) Adv. Cyclic Nucleotide Protein Phosphorylation Res. 17, 37–46.

    CAS  PubMed  Google Scholar 

  • Pritchett, D. B., Bach, A. W. J., Wozny, M., Taleb, O., Dal Toso, R., Shih, J. & Seeburg, P. H. (1988) EMBO J. 7, 4135–4140.

    CAS  PubMed  Google Scholar 

  • Raposo, G., Marullo, S., Dunia, L, André, C., Guillet, J.-G., Strosberg, A. D., Benedetti, E. L. & Hoebeke, J. (1987) Biol. Cell 60, 111–124.

    Article  Google Scholar 

  • Raposo, G., Dunia, I., Delavier-Klutchko, C., Kaveri, S., Strosberg, A. D. & Benedetti, E. L. (1989) Eur. J. Cell Biol. 50, 340–352.

    CAS  PubMed  Google Scholar 

  • Regan, J. W., Nakata, H., DeMarinis, R. M., Caron, M. G. & Lefkowitz, R. J. (1986) J. Biol. Chem. 261, 3894–3900.

    CAS  PubMed  Google Scholar 

  • Ross, E. M. (1989) Neuron 3, 141–152.

    Article  CAS  PubMed  Google Scholar 

  • Sokoloff, P., Giros, B., Martres, M. P., Bouthenet, M. L. & Schwartz, J. C. (1990) Nature 347, 146–151.

    Article  CAS  PubMed  Google Scholar 

  • Strader, C. D., Sigal, I. S., Register, R. B., Candelore, M. R., Rands, E. & Dixon, R. A. F. (1987 a) Proc. Natl Acad. Sci. USA 84, 4384–4388.

    Article  CAS  PubMed  Google Scholar 

  • Strader, C. D., Dixon, R. A. F., Cheung, A. H., Candelore, M. R., Blake, A. D. & Sigal, I. S. (1987b) J. Biol. Chem. 262, 16439–16443.

    CAS  PubMed  Google Scholar 

  • Strader, C. D., Candelore, M. R., Hill, W. S., Dixon, R. A. F. & Sigal, I. S. (1989) J. Biol. Chem. 264, 16470–16477.

    CAS  PubMed  Google Scholar 

  • Takemoto, D. J., Takemoto, L. J., Hansen, J. & Morrison, D. (1985) Biochem. J. 232, 669–672.

    CAS  PubMed  Google Scholar 

  • Tate, K., Briend-Sutren, M. M., Emorine, L. J., Delavier-Klutchko, C., Marullo, S. & Strosberg, A. D. (1991) Eur. J. Biochem (In press).

    Google Scholar 

  • Vauquelin, G., Geynet, P., Hanoune, J. & Strosberg, A. D. (1977) Proc. Natl. Acad. Sci. USA 74, 3710–3714.

    Article  CAS  PubMed  Google Scholar 

  • Vauquelin, G., Geynet, P., Hanoune, J. & Strosberg, A. D. (1979a) Eur. J. Biochem. 98, 543–556.

    Article  CAS  PubMed  Google Scholar 

  • Vauquelin, G., Bottari, S., Kanarek, L. & Strosberg, A. D. (1979b) J. Biol. Chem. 254, 4462–4469.

    CAS  PubMed  Google Scholar 

  • Wong, S. K. F., Slaughter, C., Ruoho, A. E. & Ross, E. M. (1988) J. Biol. Chem. 263, 7925–7928.

    CAS  PubMed  Google Scholar 

  • Yatani, A., Codina, J., Brown, A. M. & Birnbaumer, L. (1987) Science 255, 1288–1292.

    Article  Google Scholar 

  • Yatani, A., Imoto, Y., Codina, J., Hamilton, S. L., Brown, A. M. & Birnbaumer, L. (1988) J. Biol. Chem. 263, 9887–9895.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Strosberg, A.D. (1991). Structure/function relationship of proteins belonging to the family of receptors coupled to GTP-binding proteins. In: Christen, P., Hofmann, E. (eds) EJB Reviews 1991. EJB Reviews 1991, vol 1991. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77200-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77200-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55012-9

  • Online ISBN: 978-3-642-77200-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics