Durch die Entwicklung einer Reihe von Antidepressiva, deren pharmakologische Wirkungen spezifischer und selektiver sind als die der älteren, klassischen trizyklischen Antidepressiva (TZA), entstand ein praktisches Verfahren zur Erforschung bestimmter Aspekte depressiver Erkrankungen. Man vermutete eine besondere Verbindung des Serotoninsystems zur Stimmungsregulation (van Praag 1972); die Entwicklung von Antidepressiva mit selektiver Wirkung auf Serotonin (5-HT) sollte einen Fortschritt in der Behandlung der Depression darstellen.


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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Stuart Montgomery

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